Results 141 to 150 of about 45,597 (259)

Real-World Assessment of Weight Change in People with HIV-1 After Initiating Integrase Strand Transfer Inhibitors or Protease Inhibitors [PDF]

, 2020
Yen‐Wen Chen, Hélène Hardy, Christopher D. Pericone, Wing Chow   +3 more
openalex   +1 more source

Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression

Pharmaceuticals
Background: The global AIDS pandemic highlights the urgent need for novel antiretroviral therapies (ART). In our previous work, Zinc C295 was identified as a potent HIV-1 integrase strand transfer (ST) inhibitor. This study explores its potential to also
Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran   +8 more
doaj   +1 more source

Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration [PDF]

, 2018
Damien Bonnard, Erwann Le Rouzic, Sylvia Eiler, Céline Amadori, Igor Orlov, Jean‐Michel Bruneau, Julie Brias, Julien Barbion, Francis Chevreuil, Danièle Spehner, Sophie Chasset, Benoît Ledoussal, F. Moreau, Ali Saı̈b, Bruno P. Klaholz, Stéphane Emiliani, Marc Ruff, Alessia Zamborlini, Richard Benarous   +18 more
openalex   +1 more source

Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication

Pharmaceuticals
Background/Objectives: The development of HIV drug resistance to current antiretrovirals, and the antiretrovirals’ inability to cure HIV, provides the need of developing novel drugs that inhibit HIV-1 subtypes and drug-resistance strains.
Darian Naidu, Ernest Oduro-Kwateng, Mahmoud E. S. Soliman, Sizwe I. Ndlovu, Nompumelelo P. Mkhwanazi   +4 more
doaj   +1 more source

Use of integrase-minus lentiviral vector for transient expression [PDF]

, 2012
Objective: Lentivirus-derived vectors are among the most promising viral vectors for gene therapy which is currently available, but their use in clinical practice is limited due to associated risk of insertional mutagenesis.
Azadeh, H., Farazmandfar, T., Haghshenas, M.R., Janbabai, G., Samaei, N.M., Shahreza, H.K.   +5 more
core   +2 more sources

Potential benefit of dolutegravir once daily: efficacy and safety

HIV/AIDS: Research and Palliative Care, 2013
Alessandra Fantauzzi,1 Ombretta Turriziani,2 Ivano Mezzaroma11Department of Clinical Medicine, 2Department of Molecular Medicine, Sapienza, University of Rome, Rome, ItalyAbstract: The viral integrase enzyme has recently emerged as a primary alternative ...
Fantauzzi A, Turriziani O, Mezzaroma I
doaj  

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions. [PDF]

Structure, 2021
Gupta K, Allen A, Giraldo C, Eilers G, Sharp R, Hwang Y, Murali H, Cruz K, Janmey P, Bushman F, Van Duyne GD.   +10 more
europepmc   +1 more source

Therapeutic Opportunities in Infectious Diseases: Highlights from the Society of Medicines Research Symposium, held on March 14th 2013 at the National Heart & Lung Institute, London, UK [PDF]

, 2013
Alderton, W K, Anderson, Rosaleen, Collingwood, S P, Pryde, D C   +3 more
core   +1 more source

Audit of Antenatal Testing of Sexually Transmissible Infections and Blood Borne Viruses at Western Australian Hospitals [PDF]

, 2008
In August 2007, the Western Australian Department of Health (DOH) released updated recommendations for testing of sexually transmissible infections (STI) and blood-borne viruses (BBV) in antenates.
Combs, B. G., Giele, C. M., Kwan, K. S.H., Mak, Donna   +3 more
core   +1 more source

HIV-1 Integrase T218I/S Polymorphisms Do Not Reduce HIV-1 Integrase Inhibitors’ Phenotypic Susceptibility

AIDS Research and Human Retroviruses
The recently Food and Drug Administration (FDA)-approved cabotegravir (CAB) has demonstrated efficacy as an antiretroviral agent for HIV treatment and prevention, becoming an important tool to stop the epidemic in the United States of America (USA).
Elliott R. Rodríguez-López, Pablo López, Yadira Rodríguez, Raphael Sánchez, Van-Sergei Acevedo, Jarline Encarnación, Grissell Tirado, Carmen Ortiz-Sánchez, Thibault Mesplède, Vanessa Rivera-Amill   +9 more
openaire   +2 more sources