Results 121 to 130 of about 26,857 (227)

Novel machine learning approach toward classification model of HIV-1 integrase inhibitors

HIV-1 (Human immunodeficiency virus-1) has been causing severe pandemics by attacking the immune system of its host. Left untreated, it can lead to AIDS (acquired immunodeficiency syndrome), where death is inevitable due to opportunistic diseases ...
Gia-Bao, Truong, Thanh-An, Pham, Tuyen Ngoc, Truong, Van-Thinh, To, Phuoc-Chung Van, Nguyen, Hoang-Son Lai, Le, Tieu-Long, Phan, The-Chuong, Trinh   +7 more
core   +1 more source

HIV-1 RNP from self-avoiding Gag models.

, 2019
Genomic RNA is shown in green, integrase in yellow and nucleocapsid in blue. The RNP with integrase tetramers is shown in the context of the HIV-1 capsid (PDB entry 3j3q, shown in red).
Andrew Jewett (6836663), Arthur J. Olson (832747), Stefano Forli (652121), David S. Goodsell (734981)   +3 more
core   +1 more source

Exploring Zinc C295 as a Dual HIV-1 Integrase Inhibitor: From Strand Transfer to 3′-Processing Suppression

Pharmaceuticals
Background: The global AIDS pandemic highlights the urgent need for novel antiretroviral therapies (ART). In our previous work, Zinc C295 was identified as a potent HIV-1 integrase strand transfer (ST) inhibitor. This study explores its potential to also
Sharif Karim Sayyed, Marzuqa Quraishi, D. S. Prabakaran, Balaji Chandrasekaran, Thiyagarajan Ramesh, Satish Kumar Rajasekharan, Chaitany Jayprakash Raorane, Tareeka Sonawane, Vinothkannan Ravichandran   +8 more
doaj   +1 more source

Anti-HIV-1 integrase drugs:how far from the shelf?

, 2000
Chemotherapy of HIV-I infection/AIDS currently employs inhibitors of two products of the viral pol gene, the reverse transcriptase acid protease enzymes.
MARONGIU ME, PANI, ALESSANDRA
core   +1 more source

Alternaria alternata (Fr) Keissl Crude Extract Inhibits HIV Subtypes and Integrase Drug-Resistant Strains at Different Stages of HIV Replication

Pharmaceuticals
Background/Objectives: The development of HIV drug resistance to current antiretrovirals, and the antiretrovirals’ inability to cure HIV, provides the need of developing novel drugs that inhibit HIV-1 subtypes and drug-resistance strains.
Darian Naidu, Ernest Oduro-Kwateng, Mahmoud E. S. Soliman, Sizwe I. Ndlovu, Nompumelelo P. Mkhwanazi   +4 more
doaj   +1 more source

Allosteric HIV Integrase Inhibitors Promote Formation of Inactive Branched Polymers via Homomeric Carboxy-Terminal Domain Interactions. [PDF]

Structure, 2021
Gupta K, Allen A, Giraldo C, Eilers G, Sharp R, Hwang Y, Murali H, Cruz K, Janmey P, Bushman F, Van Duyne GD.   +10 more
europepmc   +1 more source

Análise de possíveis fatores relacionados à resistência ao HIV em parceiros soronegativos de casais HIV-sorodiscordantes da região da Grande Florianópolis [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia e Biociências, Florianópolis, 2014.Atualmente, existem diversos relatos de indivíduos que se expuseram ao HIV e não
Santos, Iris Mattos
core  

Inhibition of Adipose Tissue Beiging by HIV Integrase Inhibitors, Dolutegravir and Bictegravir, Is Associated with Adipocyte Hypertrophy, Hypoxia, Elevated Fibrosis, and Insulin Resistance in Simian Adipose Tissue and Human Adipocytes. [PDF]

Cells, 2022
Ngono Ayissi K, Gorwood J, Le Pelletier L, Bourgeois C, Beaupère C, Auclair M, Foresti R, Motterlini R, Atlan M, Barrail-Tran A, Le Grand R, Desjardins D, Fève B, Lambotte O, Capeau J, Béréziat V, Lagathu C.   +16 more
europepmc   +1 more source

Will Integrase Inhibitors be Used as Microbicides?

, 2012
Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections including HIV-1. Despite more than two decades of HIV-
Crucitti, G. C., Botta, Maurizio, DI SANTO, Roberto, Maurizio Botta, Di Santo, R., CUZZUCOLI CRUCITTI, GIULIANA   +5 more
core   +1 more source

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

, 2016
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and therefore a rational target for chemotherapeutic intervention in the treatment of HIV-1 infection. We report here the discovery
Fabio Bonelli (2417221), Federica Orvieto (2417227), Edith Monteagudo (2094247), Odalys Gonzalez Paz (2369407), Kara Stillmock (2417218), Marc V. Witmer (2417224), Marco Ferrara (2094259), Daria J. Hazuda (263416), Monica Donghi (2350966), Philip Jones (14235), Michael Rowley (2094223), Alessia Petrocchi (1586272), Fabrizio Fiore (2238334), Cristina Gardelli (2350957), Ralph Laufer (2238340), Ester Muraglia (2338012), Vincenzo Summa (2094232), Emanuela Nizi (2094238), Giovanna Pescatore (2369413), Rita Scarpelli (1463797), Olaf Kinzel (129105), Benedetta Crescenzi (1705666), Paola Pace (2335216)   +22 more
core   +1 more source