Results 111 to 120 of about 26,857 (227)

HIV Integrase Inhibitors with Nucleobase Scaffolds:  Discovery of a Highly Potent Anti-HIV Agent

, 2016
HIV integrase is essential for HIV replication. However, there are currently no integrase inhibitors in clinical use for AIDS. We have discovered a conceptually new β-diketo acid that is a powerful inhibitor of both the 3‘-processing and strand transfer ...
Vasu Nair (2139385), Guochen Chi (2139382), Roger Ptak (2653486), Nouri Neamati (275633)   +3 more
core   +1 more source

Computer tools in the discovery of HIV-1 integrase inhibitors

, 2010
Computer-aided drug design (CADD) methodologies have made great advances and contributed significantly to the discovery and/or optimization of many clinically used drugs in recent years.
Chenzhong Liao, Marc C Nicklaus
core   +1 more source

HIV integrase [PDF]

Science-Business eXchange, 2008
openaire   +3 more sources

Efficacy of Integrase Strand Transfer Inhibitors and the Capsid Inhibitor Lenacapavir against HIV-2, and Exploring the Effect of Raltegravir on the Activity of SARS-CoV-2

Viruses
Retroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase.
Irene Wanjiru Kiarie, Gyula Hoffka, Manon Laporte, Pieter Leyssen, Johan Neyts, József Tőzsér, Mohamed Mahdi   +6 more
doaj   +1 more source

Inhibition of lipid synthesis by the HIV integrase strand transfer inhibitor elvitegravir in primary rat oligodendrocyte cultures. [PDF]

Front Mol Neurosci, 2023
Monnerie H, Romer M, Roth LM, Long C, Millar JS, Jordan-Sciutto KL, Grinspan JB.   +6 more
europepmc   +1 more source

HIV‐1 Integrase Inhibition of Biscoumarin Analogues.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Su, Chang-Xiao, Mouscadet, Jean-Francois, Chiang, Chih-Chia, Tsai, Hou-Jen, Hsu, Ling-Yih   +4 more
openaire   +3 more sources

A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection. [PDF]

Retrovirology, 2022
Zhao AV, Crutchley RD, Guduru RC, Ton K, Lam T, Min AC.   +5 more
europepmc   +1 more source

First report of computational protein-ligand docking to evaluate susceptibility to HIV integrase inhibitors in HIV-infected Iranian patients. [PDF]

Biochem Biophys Rep, 2022
Ghasabi F, Hashempour A, Khodadad N, Bemani S, Keshani P, Shekiba MJ, Hasanshahi Z.   +6 more
europepmc   +1 more source

Development and application of non-integrating lentiviral vectors for gene therapy

, 2009
Lentiviruses stably integrate their genome into the host genome. Although this feature can be advantageous for long term transgene expression, it also has the potential to cause mutagenesis and cell transformation.
Apolonia, L.F.S.
core  

The role of Karyopherin β1 in the nuclear import of HIV-1 proteins

, 2014
Includes abstract.
Shaw, Tamlyn Marion
core