Results 71 to 80 of about 71,892 (273)

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, EarlyView.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study

AIDS Research and Therapy, 2020
Background In resource-limited settings, multi-experienced HIV infected patients are often prescribed raltegravir for salvage therapy. Patients failing raltegravir-containing regimens require other drugs including other integrase inhibitors.
Aurelio Orta-Resendiz, Roberto A. Rodriguez-Diaz, Luis A. Angulo-Medina, Mario Hernandez-Flores, Luis E. Soto-Ramirez   +4 more
doaj   +1 more source

Probabilistic HIV Recency Classification -- A Logistic Regression without Labeled Individual Level Training Data [PDF]

arXiv, 2021
Accurate HIV incidence estimation based on individual recent infection status (recent vs long-term infection) is important for monitoring the epidemic, targeting interventions to those at greatest risk of new infection, and evaluating existing programs of prevention and treatment.
arxiv  

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

Frontiers in Chemistry, 2019
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives as HIV integrase inhibitors (HIV INIs).
Hajar Sirous, Giulia Chemi, S. Gemma, S. Butini, Z. Debyser, F. Christ, L. Saghaie, Simone Brogi, A. Fassihi, G. Campiani, M. Brindisi   +10 more
semanticscholar   +1 more source

Resistance to inhibitors of the human immunodeficiency virus type 1 integration

Brazilian Journal of Infectious Diseases, 2010
This review will summarize the role of integrase in HIV-1 infection, the mechanism of integrase inhibitors and resistance with an emphasis on raltegravir (RAL), the first integrase inhibitor licensed to treat HIV-1 infection.
Daria J. Hazuda, PhD
doaj  

Plasma Proteomic Signature as a Predictor of Age Advancement in People Living With HIV

Aging Cell, EarlyView.
We developed a prediction model of biological age based on 77 plasma proteins that were associated with chronological age in two independent cohorts of PLHIV and one cohort of people without HIV. PLHIV exhibited an increased age advancement that was positively associated with previous co‐infections and non‐AIDS‐related comorbidities, a higher ...
Adriana Navas, Vasiliki Matzaraki, Louise E. van Eekeren, Marc J. T. Blaauw, Albert L. Groenendijk, Wilhelm A. J. W. Vos, Maartje Jacobs‐Cleophas, Jéssica C. dos Santos, André J. A. M. van der Ven, Leo A. B. Joosten, Mihai G. Netea   +10 more
wiley   +1 more source

HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors

eLife, 2019
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN.
Pratibha C. Koneru, A. C. Francis, N. Deng, Stephanie V. Rebensburg, Ashley C Hoyte, J. Lindenberger, Daniel Adu-Ampratwum, Ross C. Larue, M. Wempe, A. Engelman, D. Lyumkis, J. Fuchs, R. Levy, G. Melikyan, M. Kvaratskhelia   +14 more
semanticscholar   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

HIV drug resistance against strand transfer integrase inhibitors

Retrovirology, 2017
Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be approved for treatment and act by inhibiting the essential HIV protein integrase from inserting the viral DNA genome into the host cell’s chromatin.
Kaitlin Anstett, B. Brenner, T. Mesplède, M. Wainberg   +3 more
semanticscholar   +1 more source