Results 91 to 100 of about 629,767 (276)

Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases

Advanced Science, EarlyView.
Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao, Victor Fernandez‐Gonzalez, Xiaochuan Wang, Blake Pylipow, Claudia Herrera, Xiaohu Xia   +5 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A population-based survey pooled analysis of women engaged in commercial sex in the HIV care cascade in sub-Saharan Africa, 2015–2017

Discover Public Health
Introduction Women who engage in commercial sex (WCS) have a higher prevalence of HIV in sub-Saharan Africa than other women of reproductive age. We aimed to describe the burden of HIV, testing, treatment, and viral load suppression (VLS) coverage among ...
Forrest Larson, Gordon Le, Italia V. Rolle, Madeline Sands, Faith Ussery, Abraham Ater, Abu Abdul-Quader, Gary Sardon, Neena M. Philip, Felix Ndagije, Gerald Mwima, George Mgomella, Fred M. Asiimwe, Tendayi Mharadze, Nzali G. Kancheya, Fatima Glyn Zulu, Mandzisi Mkhontfo   +16 more
doaj   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Alcohol use and sexual risk behaviors in the Armed Forces of the Democratic Republic of the Congo

BMC Public Health, 2019
Background Alcohol misuse is an important contributor to sexual acquisition and transmission of HIV in military communities. This cross-sectional study quantified the prevalence of probable problematic alcohol use among male service members in the Armed ...
Bonnie Robin Tran, Anthony Davis, Margo Sloan, Carol Macera, Anthony Mutombe Mbuyi, Gilbert Kurhgnga Kabanda   +5 more
doaj   +1 more source

HIV testing and HIV prevention in Sweden [PDF]

BMJ, 1998
HIV testing is central to Sweden's programme of preventing the spread of HIV infection. It has been widely promoted and encouraged on the grounds that once HIV infected people are aware of their serostatus and receive appropriate counselling, they will take the necessary steps to protect their partners.1 This faith in the inclination of citizens to ...
openaire   +2 more sources

Navigating an STI diagnosis: The role of social support, intergenerational learning, and transformative growth among Black women

American Journal of Community Psychology, EarlyView.
Abstract Black women face a myriad of challenges that heighten their susceptibility to sexually transmitted infections (STIs), resulting in a disproportionate impact of STIs among this population. Yet, there is a lack of research that explores how women navigate these diagnoses with resilience.
Jaleah D. Rutledge, Jasmine Abrams, Ijeoma Opara, Robin Lin Miller   +3 more
wiley   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

The intersection of health inequalities and COVID‐19: Evidence from National Health Insurance Big Data in South Korea

American Journal of Community Psychology, EarlyView.
Abstract Health inequalities persist along lines of income and wealth, shaped by unequal access to healthcare, differences in health behaviors, and pre‐existing chronic conditions. The COVID‐19 pandemic further put families in Korea under health strain and worsened their health outcomes.
Jaehyun Nam, Sarah Jiyoon Kwon, Wonik Lee, Eunji Kim   +3 more
wiley   +1 more source