In silico prediction of mutant HIV-1 proteases cleaving a target sequence. [PDF]
PLoS ONE, 2014 HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636-1648) published a
Jan H Jensen +3 more
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HIV Protease: Historical Perspective and Current Research [PDF]
Viruses, 2021 The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to control the disease are undermined by the growing threat posed by ...
Irene T. Weber +2 more
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Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors [PDF]
VirusesCervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo +2 more
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Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities [PDF]
Frontiers in Molecular Biosciences, 2022 Cervical cancer is a Human Papilloma virus-related disease, which is on the rise in a number of countries, globally. Two essential oncogenes, E6 and E7, drive cell transformation and cancer development.
Lilian Makgoo +2 more
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HIV protease inhibitors restore amphotericin B activity against Candida. [PDF]
PLoS ONECandida auris is an invasive fungal pathogen, representing a global public health threat. It is characterized by high mortality rates among infected individuals, significant antifungal resistance, and a remarkable ability to persist in healthcare ...
Yehia Elgammal +2 more
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HIV protease cleaves the antiviral m6A reader protein YTHDF3 in the viral particle. [PDF]
PLoS Pathogens, 2020 N6-methyladenosine (m6A) is the most abundant HIV RNA modification but the interplay between the m6A reader protein YTHDF3 and HIV replication is not well understood.
Denise Jurczyszak +9 more
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Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells. [PDF]
PLoS Pathogens, 2010 In medicine, understanding the pathophysiologic basis of exceptional circumstances has led to an enhanced understanding of biology. We have studied the circumstance of HIV-infected patients in whom antiretroviral therapy results in immunologic benefit ...
Sekar Natesampillai +6 more
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Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication. [PDF]
PLoS ONE, 2008 Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1.
Gary D Bren +6 more
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Predicting HIV-1 Protease Cleavage Sites With Positive-Unlabeled Learning
Frontiers in Genetics, 2021 Understanding the substrate specificity of HIV-1 protease plays an essential role in the prevention of HIV infection. A variety of computational models have thus been developed to predict substrate sites that are cleaved by HIV-1 protease, but most of ...
Zhenfeng Li +3 more
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Ultra-fast analysis of plasma and intracellular levels of HIV protease inhibitors in children: a clinical application of MALDI mass spectrometry. [PDF]
PLoS ONE, 2010 HIV protease inhibitors must penetrate into cells to exert their action. Differences in the intracellular pharmacokinetics of these drugs may explain why some patients fail on therapy or suffer from drug toxicity.
Jeroen J A van Kampen +10 more
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