Results 171 to 180 of about 184,582 (277)

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2. [PDF]

J Med Chem
Haymer DH, Duncan RA, Rodriguez AL, Han A, Lindsay RJ, Wijesiri NK, Thompson Gray A, Krishnan S, Qi A, Brown BP, Boutaud O, Engers DW, Jones CK, Niswender CM, Lindsley CW, Bender AM.   +15 more
europepmc   +1 more source

Dengue Virus Capsid Protein Interaction With Nucleic Acids

BioFactors, Volume 52, Issue 3, May/June 2026.
Binding of dengue virus capsid protein (DENV C) to ssDNA alters Trp fluorescence intensity, lifetime, and anisotropy, revealing structural rearrangements in the complex and suggesting a possible association with liquid–liquid phase separation (LLPS). ABSTRACT Dengue virus (DENV) transmission has greatly increased in the last decade, partly due to the ...
Nelly M. Silva, Ana S. Martins, Nina E. Karguth, Maria J. Sarmento, Francisco J. Enguita, Roland G. Huber, Ivo C. Martins, Nuno C. Santos   +7 more
wiley   +1 more source

Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2's main protease. [PDF]

Virol J, 2020
Mahdi M, Mótyán JA, Szojka ZI, Golda M, Miczi M, Tőzsér J.   +5 more
europepmc   +2 more sources

Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design. [PDF]

Molecules, 2021
Yu W, Wu X, Zhao Y, Chen C, Yang Z, Zhang X, Ren J, Wang Y, Wu C, Li C, Chen R, Wang X, Zheng W, Liao H, Yuan X.   +14 more
europepmc   +1 more source

Methods of Inner Filter Effect Correction in Fluorescence Measurements of Protein–Ligand Association: A Re‐Examination of the Association of Anti‐HIV Drugs to Serum Albumin

Chemistry–Methods, Volume 6, Issue 5, May 2026.
Fluorescence experiments to estimate the association constant avoiding the Inner Filter Effect on HSA titration with ligand. An excursus of the principal methodologies to identify and correct the IFE artifact. Fluorescence‐based methods are widely used to assess protein–ligand and protein–protein interactions.
Filippo Savini, Sara Bobone, Lorenzo Stella, Daniela Roversi, Alessio Bocedi   +4 more
wiley   +1 more source

Development and characterization of high-affinity aptamers for HIV protease detection. [PDF]

Heliyon
Valadés-Alcaraz A, Reinosa R, González-Hevilla M, Medina-Sánchez C, Holguín Á.   +4 more
europepmc   +1 more source

The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia. [PDF]

Sci Transl Med, 2021
Caffall ZF, Wilkes BJ, Hernández-Martinez R, Rittiner JE, Fox JT, Wan KK, Shipman MK, Titus SA, Zhang YQ, Patnaik S, Hall MD, Boxer MB, Shen M, Li Z, Vaillancourt DE, Calakos N.   +15 more
europepmc   +1 more source

Maternal‐to‐Infant Transfer of Medications for Type 2 Diabetes Mellitus Via Breastmilk: A Systematic Review of Available Evidence and Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1223-1234, May 2026.
This review evaluates the available pharmacokinetic data on the plasma‐to‐breastmilk transfer of first‐ and second‐line T2DM drugs against available clinical guideline recommendations. A list of drug therapies for treating T2DM was generated from national and international clinical guidelines.
Katherine Richardson, Joshua Kiptoo, Beatrice Mpora Odongkara, Francis Williams Ojara, Catriona Waitt   +4 more
wiley   +1 more source

Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal Formulation. [PDF]

Int J Mol Sci
Crispo F, Vassallo A, Faraone I, Santarsiere A, Chiummiento L, Martinelli M, Cascelli N, Fernàndez-Busquets X, Miglionico R, Nigro I, Caddeo C, Armentano MF.   +11 more
europepmc   +1 more source