Results 151 to 160 of about 184,582 (277)
Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE Electrochemical Biosensor. [PDF]
ACS Omega, 2023 Thongkum W +7 more
europepmc +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.ABSTRACT Background Sepsis‐induced myopathy (SIM) is a common and life‐threatening complication, but its underlying mechanisms remain poorly understood. PACS2, a key resident protein at mitochondria‐associated endoplasmic reticulum membranes (MAMs), regulates ER homeostasis under various pathological conditions.
Xuexin Li +7 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq +2 more
wiley +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source
Revertant mutation V48G alters conformational dynamics of highly drug resistant HIV protease PRS17. [PDF]
J Mol Graph Model, 2021 Burnaman SH +4 more
europepmc +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT The approval requirements in new regions that do not require domestic clinical data and the clinical data evaluation of multi‐regional clinical trials (MRCTs) and foreign clinical trials (FCTs) in the Japanese approval review processes for antimicrobial medicines were explored.
Rumiko Shimazawa, Masayuki Ikeda
wiley +1 more source
Suspected bradycardia due to interactions between HIV protease inhibitors and lidocaine: a case report. [PDF]
J Dent Anesth Pain Med, 2021 Hamaya E, Kamekura N, Fujisawa T.
europepmc +1 more source
Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease
Immunology, Volume 178, Issue 2, Page 218-230, June 2026.This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley +1 more source
Evolution of drug resistance in HIV protease. [PDF]
BMC Bioinformatics, 2020 Shah D, Freas C, Weber IT, Harrison RW.
europepmc +1 more source
HIV Protease Inhibitors and Insulin Sensitivity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]
Front Pharmacol, 2021 Kajogoo VD +8 more
europepmc +1 more source