Results 131 to 140 of about 95,049 (250)

Viruses, Periodontitis, and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the viral involvement in periodontitis and its relevance for systemic diseases. The oral cavity acts as an active viral reservoir and dissemination platform, where virus–microbiome interactions may promote dysbiosis, periodontitis progression, and systemic inflammatory effects, while the ...
Kim Natalie Solte, Yvonne L. Hernandez‐Kapila, Henrik Dommisch   +2 more
wiley   +1 more source

Live-Cell Raman Imaging Elucidates Intracellular Distribution of Macrocyclic Peptides Designed as HIV Protease Inhibitors. [PDF]

Chem Biomed Imaging
Nawa Y, Miyano T, Bando K, Mitsuki S, Hayashi K, Tanaka Y, Ueda H, Fujita S, Fujita K.   +8 more
europepmc   +1 more source

HIV protease [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

The Association of Pretransplant CD4 Count With Post‐Kidney Transplant Infectious Outcomes Among Persons With HIV

Transplant Infectious Disease, EarlyView.
In this multi‐center study comparing persons with HIV with pre‐kidney transplant CD4 < 350 cells/µL to those with ≥ 350 cells/µL, we found no difference in relative risk of infection in the first year‐post kidney transplant, 5‐year graft survival, and 5‐year overall survival.
Rebecca H. Burns, Sara Booth, Christin Rogers Marks, Christine M. Durand, Jonathan Hand, Maheen Z. Abidi, Maricar Malinis, Brittany Barnaba, Martha Pavlakis, Douglas Krakower, Carolyn D. Alonso, Audrey Le‐Mahajan   +11 more
wiley   +1 more source

Asymmetric Synthesis of the HIV Protease Inhibitor TMC-126, a PMX Antimalarial Protease Inhibitor, and a Putative COVID-19 Inhibitor Using a Highly Stereoselective Glycolate Aldol Addition Reaction Pathway. [PDF]

ACS Omega
Affram KA, Carter A, Breede A, Kimsey A, Hemeson G, Semakieh B, Martinez M, Ayim E, Odeh J, Hitchcock SR.   +9 more
europepmc   +1 more source

Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End‐Stage Renal Disease

Transplant Infectious Disease, EarlyView.
Among people living with HIV and end‐stage renal disease evaluated for kidney transplantation, most progressed successfully through evaluation and were waitlisted once engaged in the process. However, substantial delays occurred across the transplant continuum, with attrition driven primarily by incomplete testing and structural barriers rather than ...
Kyle M. Crawford, Jillian Catalano, Dhriti Shah, Scott Curry, Alexandra G. Mills, Yosra Alkabab, Drew Charles, Courtney E. Harris, Ruth O. Adekunle   +8 more
wiley   +1 more source

Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2. [PDF]

J Med Chem
Haymer DH, Duncan RA, Rodriguez AL, Han A, Lindsay RJ, Wijesiri NK, Thompson Gray A, Krishnan S, Qi A, Brown BP, Boutaud O, Engers DW, Jones CK, Niswender CM, Lindsley CW, Bender AM.   +15 more
europepmc   +1 more source

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co‐Infected With HIV

Tropical Medicine &International Health, EarlyView.
ABSTRACT Background HIV co‐infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first‐line anti‐TB drugs and clinical outcomes in patients with and without HIV co‐infection. Methods In this prospective observational study, 61 adults with sputum‐positive pulmonary TB, either confirmed ...
Aung Pyae Phyo, Richard M. Hoglund, Makoto Saito, Sein Sein Thi, Lei Lei Swe, Palang Chotsiri, Htet Ko Ko Aung, Win Pa Pa Tun, Banyar Maung Maung, Chanapat Pateekham, Wanitda Watthanaworawit, Gornpan Gornsawun, Nicholas J. White, Francois Nosten, Joel Tarning   +14 more
wiley   +1 more source

Computational Simulation of HIV Protease Inhibitors to the Main Protease (Mpro) of SARS-CoV-2: Implications for COVID-19 Drugs Design. [PDF]

Molecules, 2021
Yu W, Wu X, Zhao Y, Chen C, Yang Z, Zhang X, Ren J, Wang Y, Wu C, Li C, Chen R, Wang X, Zheng W, Liao H, Yuan X.   +14 more
europepmc   +1 more source

Microgravity‐induced changes in skeletal muscle and possible countermeasures: What we can learn from bed rest and human space studies

Experimental Physiology, EarlyView.
Abstract Despite exercise countermeasures to sustain health and performance in spaceflight, complete maintenance of muscle mass and functions in microgravity is still not possible for most astronauts. The principal cause of the limited effectiveness of existing exercise countermeasures is the difficulty in achieving full loading forces in space.
Alessandra Bosutti, Bergita Ganse, Nicola A. Maffiuletti, Rob C. I. Wüst, Gustav J. Strijkers, Andy Sanderson, Hans Degens   +6 more
wiley   +1 more source