Results 141 to 150 of about 95,049 (250)

Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2's main protease. [PDF]

Virol J, 2020
Mahdi M, Mótyán JA, Szojka ZI, Golda M, Miczi M, Tőzsér J.   +5 more
europepmc   +2 more sources

Development and characterization of high-affinity aptamers for HIV protease detection. [PDF]

Heliyon
Valadés-Alcaraz A, Reinosa R, González-Hevilla M, Medina-Sánchez C, Holguín Á.   +4 more
europepmc   +1 more source

The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia. [PDF]

Sci Transl Med, 2021
Caffall ZF, Wilkes BJ, Hernández-Martinez R, Rittiner JE, Fox JT, Wan KK, Shipman MK, Titus SA, Zhang YQ, Patnaik S, Hall MD, Boxer MB, Shen M, Li Z, Vaillancourt DE, Calakos N.   +15 more
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Repurposing HIV-Protease Inhibitor Precursors as Anticancer Agents: The Synthetic Molecule RDD-142 Delays Cell Cycle Progression and Induces Autophagy in HepG2 Cells with Enhanced Efficacy via Liposomal Formulation. [PDF]

Int J Mol Sci
Crispo F, Vassallo A, Faraone I, Santarsiere A, Chiummiento L, Martinelli M, Cascelli N, Fernàndez-Busquets X, Miglionico R, Nigro I, Caddeo C, Armentano MF.   +11 more
europepmc   +1 more source

HIV protease inhibitors Nelfinavir and Lopinavir/Ritonavir markedly improve lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect. [PDF]

Antiviral Res, 2022
Foo CS, Abdelnabi R, Kaptein SJF, Zhang X, Ter Horst S, Mols R, Delang L, Rocha-Pereira J, Coelmont L, Leyssen P, Dallmeier K, Vergote V, Heylen E, Vangeel L, Chatterjee AK, Annaert PP, Augustijns PF, De Jonghe S, Jochmans D, Gouwy M, Cambier S, Vandooren J, Proost P, van Laer C, Weynand B, Neyts J.   +25 more
europepmc   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

In Silico Evaluation of HIV Protease and RNA Polymerase Inhibitors as Potential COVID-19 Therapeutics. [PDF]

Cureus
Devaraji M, Ravikumar L.
europepmc   +1 more source

Conformational asymmetry of human immunodeficiency virus‐1 protease flaps increases along the darunavir drug resistance pathway

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Under selective drug pressure, the structure and dynamics of HIV‐1 protease (PR) evolve to confer resistance to the drug. Here, we report on the conformational changes in PR flaps for drug‐resistance mutations using 19F nuclear magnetic resonance (NMR) spectroscopy.
Michel Guerrero, Roman Zadorozhnyi, Guowu Lin, Caitlin M. Quinn, Guillermo Calero, Nese Kurt‐Yilmaz, Celia A. Schiffer, Tatyana Polenova, Angela M. Gronenborn, Rieko Ishima   +9 more
wiley   +1 more source

Novel combinatorial approach: Harnessing HIV protease inhibitors to enhance amphotericin B's antifungal efficacy in cryptococcosis. [PDF]

PLoS One
Alkashef NM, Seleem MN.
europepmc   +1 more source