Results 131 to 140 of about 58,483 (238)

Conformational asymmetry of human immunodeficiency virus‐1 protease flaps increases along the darunavir drug resistance pathway

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Under selective drug pressure, the structure and dynamics of HIV‐1 protease (PR) evolve to confer resistance to the drug. Here, we report on the conformational changes in PR flaps for drug‐resistance mutations using 19F nuclear magnetic resonance (NMR) spectroscopy.
Michel Guerrero, Roman Zadorozhnyi, Guowu Lin, Caitlin M. Quinn, Guillermo Calero, Nese Kurt‐Yilmaz, Celia A. Schiffer, Tatyana Polenova, Angela M. Gronenborn, Rieko Ishima   +9 more
wiley   +1 more source

Enhanced antifungal activity of posaconazole against Candida auris by HIV protease inhibitors, atazanavir and saquinavir. [PDF]

Sci Rep
Elgammal Y, Salama EA, Seleem MN.
europepmc   +1 more source

Applications of Click Chemistry in the Development of HIV Protease Inhibitors. [PDF]

Int J Med Chem, 2018
Mudgal MM, Birudukota N, Doke MA.
europepmc   +1 more source

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition

Protein Science, Volume 35, Issue 9, September 2026.
Abstract In bacteria, DnaB replicative helicases are essential for unwinding genomic DNA to provide the single‐stranded templates required for replication. The recruitment of the hexameric DnaB helicase to the origin of replication is mediated by distinct mechanisms that rely on specialized factors known as helicase loaders. The DciA family of helicase
Daniele Mazzoletti, Andrea Garavaglia, Hayden Fisher, Nicholas Gao, Castrese Morrone, Paul Dominic B. Olinares, Brian T. Chait, David Jeruzalmi, Riccardo Miggiano   +8 more
wiley   +1 more source

Counteracting Akt Activation by HIV Protease Inhibitors in Monocytes/Macrophages. [PDF]

Viruses, 2018
Pasquereau S, Kumar A, Abbas W, Herbein G.   +3 more
europepmc   +1 more source

Immature Neutrophil Phenotype and Enhanced Myeloperoxidase in Male Patients With Chronic Kidney Disease and Cardiovascular Comorbidity

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim Patients with chronic kidney disease (CKD) have an increased cardiovascular risk. Since neutrophils and neutrophil‐borne proteins contribute to cardiovascular disease, we analyzed the neutrophil phenotype in patients with CKD who presented with a spectrum of cardiovascular comorbidities.
Sonja Vondenhoff, Alessandra Antwerpen, Carolina Victoria Cruz Junho, Philipp Martin, Sina Hourtz, Jinmi Zou, Berkan Kurt, Carolin Haas, Susanne Fleig, Corinna Schulte, Jane Lauxen, Martina Wessiepe, Ulrike Späte‐Schulze, Rafael Kramann, Jürgen Floege, Oliver Soehnlein, Joachim Jankowski, Claudia Goettsch, Yvonne Döring, Florian Kahles, Nikolaus Marx, Constance C. F. M. J. Baaten, Heidi Noels   +22 more
wiley   +1 more source

HIV protease inhibitors block parasite signal peptide peptidases and prevent growth of Babesia microti parasites in erythrocytes. [PDF]

Biochem Biophys Res Commun, 2019
Schwake C, Baldwin MR, Bachovchin W, Hegde S, Schiemer J, Okure C, Levin AE, Vannier E, Hanada T, Chishti AH.   +9 more
europepmc   +1 more source

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and senolytic effects in vitro and in animal models, but evidence from randomised
Juliette Tavenier, Magnus Berglind, Line Fleischer Hach, Louise Westberg Strejby Christensen, Maria Jana Masarikova, Rafal Yahya, Mette Bendtz Lindstrøm, Baker Nawfal Jawad, Anna Zatkova, Rikke Lundsgaard Nielsen, Helle Gybel Juul‐Larsen, Thomas Kallemose, Jan Olof Nehlin, Morten Baltzer Houlind, Ove Andersen, Line Jee Hartmann Rasmussen   +15 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Synthesis of β‐Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25

ChemBioChem, Volume 27, Issue 15, 14 August 2026.
Lasso peptide, Microcin J25 (MccJ25), exhibits extreme stability and potent antibacterial activity against Gram‐negative bacteria due to its rigid “lariat” structure. However, this unique topology precludes researchers to achieve the total chemical synthesis. Herein, we investigated the chemical synthetic prestapling strategy toward synthesis of MccJ25
Yu‐Ting Hsiao, Bethan L. Heard, Ilia Perov, Marco J. van Belkum, Sorina Chiorean, Kaitlyn Towle, Isaac Antwi, John C. Vederas   +7 more
wiley   +1 more source