Results 1 to 10 of about 48,965 (195)
Promotion of HIV clearance by sensitization of HIV reservoirs to cell death [PDF]
Frontiers in ImmunologyIntroductionHIV integrates its proviral DNA into the host genome to establish persistent infection. To promote HIV clearance, we have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through ...
Min Li +10 more
doaj +2 more sources
Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st–4th 2023, Malahide Ireland [PDF]
Pathogens and Immunity, 2023 The inaugural FASEB HIV Reservoirs and Immune Control Conference brought researchers together from across the globe to discuss reservoir dynamics in clinical cohorts. It extended over 4 days in the seaside town of Malahide, Ireland.
Una O’Doherty +2 more
doaj +2 more sources
Impact of a decade of successful antiretroviral therapy initiated at HIV-1 seroconversion on blood and rectal reservoirs [PDF]
eLife, 2015 Persistent reservoirs remain the major obstacles to achieve an HIV-1 cure. Prolonged early antiretroviral therapy (ART) may reduce the extent of reservoirs and allow for virological control after ART discontinuation.
Eva Malatinkova +11 more
doaj +4 more sources
Host factors and early treatments to restrict paediatric HIV infection and early disease progression [PDF]
Journal of Virus Eradication, 2015 A body of evidence indicates that a threshold level of the virus is required to establish systemic and persistent HIV infection in the host and that this level depends on virus–host interactions.
Ketty Gianesin +5 more
doaj +10 more sources
Stem cell–derived CAR T cells traffic to HIV reservoirs in macaques [PDF]
JCI Insight, 2021 Allogeneic hematopoietic stem cell transplantation (allo-HSCT) with CCR5– donor cells is the only treatment known to cure HIV-1 in patients with underlying malignancy.
Isaac M. Barber-Axthelm +9 more
doaj +2 more sources
HIV Reservoirs and Treatment Strategies toward Curing HIV Infection. [PDF]
Int J Mol SciCombination antiretroviral therapy (cART) has significantly improved the prognosis of individuals living with human immunodeficiency virus (HIV). Acquired immunodeficiency syndrome has transformed from a fatal disease to a treatable chronic infection. Currently, effective and safe anti-HIV drugs are available.
Matsuda K, Maeda K.
europepmc +3 more sources
Nanotechnology approaches to eradicating HIV reservoirs. [PDF]
Eur J Pharm Biopharm, 2019 The advent of combination antiretroviral therapy (cART) has transformed HIV-1 infection into a controllable chronic disease, but these therapies are incapable of eradicating the virus to bring about an HIV cure. Multiple strategies have been proposed and investigated to eradicate latent viral reservoirs from various biological sanctuaries. However, due
Cao S, Woodrow KA.
europepmc +4 more sources
Update on HIV reservoirs [PDF]
Retrovirology, 2010 Aim During combination antiretroviral therapy, reduction of HIV-1 RNA levels to less than 50 copies/ml is frequently achieved; however, residual low-level viremia has been detected using ultrasensitive assays. The source of persistent viremia is currently unknown: it could arise from ongoing cycles of replication in a sanctuary site, long-lived ...
Palmer Sarah
doaj +2 more sources
Update on HIV reservoirs [PDF]
BMC Infect Dis, 2014 The stable latent reservoir for HIV-1 in resting memory CD4+ T cells is a major barrier to curing HIV-1/AIDS. Studies on HIV-1 latency focused on regulation and reactivation of viral gene expression in the cells in which viral latent infection is already established. However, it is not well understood how virus becomes latent.
Shan L.
europepmc +3 more sources
Recent progress in understanding HIV reservoirs. [PDF]
Curr Opin HIV AIDS, 2018 Reservoirs of HIV-1-infected cells persist long-term despite highly effective antiretroviral suppression therapy and represent the main barrier against a cure for HIV-1. This review summarizes recent advances in understanding the complexity and diversity of viral reservoir cells.Latently infected memory CD4 T cells are the predominant cell compartment ...
Kuo HH, Lichterfeld M.
europepmc +4 more sources