Results 91 to 100 of about 48,965 (195)

Role of long noncoding RNA in regulating HIV infection—a comprehensive review

mBio
A complete cure against human immunodeficiency virus (HIV) infection remains out of reach, as the virus persists in stable cell reservoirs that are resistant to antiretroviral therapy.
Noa Amir, Ran Taube
doaj   +1 more source

Ex vivo and in vivo HIV-1 latency reversal by “Mukungulu,” a protein kinase C-activating African medicinal plant extract

mBio
New HIV latency-reversing agents (LRAs) are needed that can reactivate and/or eliminate HIV reservoirs. “Mukungulu,” prepared from the plant Croton megalobotrys Müll Arg., is traditionally used for HIV/AIDS management in northern Botswana despite an ...
Khumoekae Richard, Zhe Yuan, Hsin-Yao Tang, Aaron R. Goldman, Riza Kuthu, Boingotlo Raphane, Emery T. Register, Paridhima Sharma, Brian N. Ross, Jessicamarie Morris, David E. Williams, Carol Cheney, Guoxin Wu, Karam Mounzer, Gregory M. Laird, Paul Zuck, Raymond J. Andersen, Sundana Simonambango, Kerstin Andrae-Marobela, Ian Tietjen, Luis J. Montaner   +20 more
doaj   +1 more source

Effect of Treatment, during Primary Infection, on Establishment and Clearance of Cellular Reservoirs of HIV-1 [PDF]

, 2017
Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human immunodeficiency virus type 1 (HIV-1); this retention is an obstacle to sustained control of infection. To
Daar, Eric S., Daly, Otto A., Günthard, Huldrych F., Havlir, Diane V., Ignacio, Caroline C., Lam, Ruby Y., Little, Susan J., Nguyen, Juin, Richman, Douglas D., Spina, Celsa A., Strain, Matthew C., Wong, Joseph K.   +11 more
core  

Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART

, 2004
When highly active antiretroviral therapy is administered for long periods of time to HIV-1 infected patients, most patients achieve viral loads that are ``undetectable'' by standard assay (i.e., HIV-1 RNA $ < 50$ copies/ml).
Jones, Laura E., Perelson, Alan S.
core   +1 more source

Beyond the replication-competent HIV reservoir: transcription and translation-competent reservoirs

Retrovirology, 2018
Recent years have seen a substantial increase in the number of tools available to monitor and study HIV reservoirs. Here, we discuss recent technological advances that enable an understanding of reservoir dynamics beyond classical assays to measure the ...
Amy E. Baxter, Una O’Doherty, Daniel E. Kaufmann   +2 more
doaj   +1 more source

Use of ‘eradication’ in HIV cure-related research: a public health debate

BMC Public Health, 2018
Background The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted
Karine Dubé, Stuart Luter, Breanne Lesnar, Luke Newton, Jerome Galea, Brandon Brown, Sara Gianella   +6 more
doaj   +1 more source

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption. [PDF]

, 2019
The role of lymphoid tissue as a potential source of HIV-1 rebound following interruption of antiretroviral therapy (ART) is uncertain. To address this issue, we compared the latent viruses obtained from CD4+ T cells in peripheral blood and lymph nodes ...
Ablanedo-Terrazas, Yuria, Barton, John P, Cohen, Yehuda Z, Damsgaard, Tine, Del Rio Estrada, Perla M, Denton, Paul W, Garcia Noceda, Marco, Lorenzi, Julio CC, Lu, Ching-Lan, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy A, Reyes-Teran, Gustavo, Søgaard, Ole S, Tolstrup, Martin, Vibholm, Line K   +15 more
core   +1 more source

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

Frontiers in Immunology
Highly active antiretroviral therapy (HAART) suppresses viral loads in 71% of people living with HIV globally, while failing to bring adequate immune reconstitution in nearly one-third of them. We hypothesize that the persistence of latent HIV reservoirs
Selwyn Selva Kumar, John Paul Demosthenes, Madheswaran A., Milton P., Inbanathan A., Nagaraj V., Abi Manesh, Saravanabhavan Thangavel, Luke Elizabeth Hanna, Rajesh Kannangai, George M. Varghese   +10 more
doaj   +1 more source

PROSPECTS FOR OBTAINING VALUABLE PRODUCTS FROM CYANOBACTERIA BIOMASS [PDF]

, 2018
Relevance. The construction of a thread of reservoirs on the Dnieper River in the middle of the twentieth century allowed to solve a number of important issues related to navigation, supply of water and electric power to industrial facilities, etc ...
Digtiar, Sergii, Kozlovska, Tetyana, Yelizarov, Mykhailo   +2 more
core  

The Proviral Reservoirs of Human Immunodeficiency Virus (HIV) Infection

Pathogens
Human Immunodeficiency Virus (HIV) proviral reservoirs are cells that harbor integrated HIV proviral DNA within their nuclear genomes. These cells form a heterogeneous group, represented by peripheral blood mononuclear cells (PBMCs), tissue-resident ...
Andrey I. Murzin, Kirill A. Elfimov, Natalia M. Gashnikova   +2 more
doaj   +1 more source