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Mechanisms of
SummaryThe establishment and maintenance of HIV reservoirs that lead to persistent viremia in patients on antiretroviral drugs remains the greatest challenge of the highly active antiretroviral therapy era. Cellular reservoirs include resting memory CD4+ T lymphocytes, implicated as the major HIV reservoir, having a half‐life of approximately 44 months
Mayibongwe L. Mzingwane +1 more
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Astrocytes as an HIV Reservoir: Mechanism of HIV Infection
Current HIV Research, 2016If we have any hope of achieving a cure for HIV infection, close attention to the cell types capable of getting infected with HIV is necessary. Of these cell types, astrocytes are the most ideal cell type for the formation of such a reservoir. These are long-lived cells with a very low turnover rate and are found in the brain and the gastrointestinal ...
Guan-Han, Li +2 more
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Phylogenies in ART: HIV reservoirs, HIV latency and drug resistance
Current Opinion in Pharmacology, 2019Combination antiretroviral therapy (ART) has significantly reduced the morbidity and mortality resulting from HIV infection. ART is, however, unable to eradicate HIV, which persists latently in several cell types and tissues. Phylogenetic analyses suggested that the proliferation of cells infected before ART initiation is mainly responsible for ...
Bandera A. +3 more
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Current Opinion in HIV and AIDS, 2018
A number studies are currently underway to develop new drugs aimed at reducing the HIV reservoir or achieving ART-free control of HIV infection. Many markers of HIV reservoirs have been proposed, each one having a different meaning. Total HIV DNA dynamics during the course of HIV infection and its predictive value are now well known.
Christine, Rouzioux +2 more
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A number studies are currently underway to develop new drugs aimed at reducing the HIV reservoir or achieving ART-free control of HIV infection. Many markers of HIV reservoirs have been proposed, each one having a different meaning. Total HIV DNA dynamics during the course of HIV infection and its predictive value are now well known.
Christine, Rouzioux +2 more
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Viral reservoirs and HIV-specific immunity
Current Opinion in Internal Medicine, 2006HIV-1 infection is complicated by the presence of latently infected CD4 T cells as well as several anatomical reservoirs that present a barrier to eradication by current antiretroviral therapy. The early establishment of these reservoirs also presents a challenge to the development of preventive vaccines.
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Nature Medicine, 2001
The persistence of latently infected T cells is a major hurdle to eradication of HIV by antiviral therapy. It now seems that HIV latency can occur during normal T-cell differentiation in the thymus, and is regulated by the overall state of cellular gene transcription (pages 459–464 ).
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The persistence of latently infected T cells is a major hurdle to eradication of HIV by antiviral therapy. It now seems that HIV latency can occur during normal T-cell differentiation in the thymus, and is regulated by the overall state of cellular gene transcription (pages 459–464 ).
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Current opinion in investigational drugs (London, England : 2000), 2003
HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infection. Residual disease is maintained via proviral latency in resting CD4+ T-lymphocytes and possibly monocytes ...
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Cervical cancer prevention and control in women living with human immunodeficiency virus
Ca-A Cancer Journal for Clinicians, 2021Philip E Castle, Vikrant V Sahasrabuddhe
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Prevention, treatment and cure of HIV infection
Nature Reviews Microbiology, 2023Raphael J Landovitz +2 more
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