Results 11 to 20 of about 48,965 (195)
Reduction of the HIV-1 reservoir in T cells from people with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells [PDF]
mBioTreatment with latency-reversing agents (LRAs) alone has been ineffective in reducing HIV-1 reservoirs in people living with HIV-1 (PLWH) who are on antiretroviral therapy (ART), due to inefficiencies in reservoir reactivation and adaptive immune ...
Mary Ann Checkley +12 more
doaj +2 more sources
Viruses, 2021 Antiretroviral therapy (ART) has dramatically suppressed human immunodeficiency virus (HIV) replication and become undetectable viremia. However, a small number of residual replication-competent HIV proviruses can still persist in a latent state even ...
Xiaolei Wang, Huanbin Xu
doaj +1 more source
The Interplay of HIV-1 and Macrophages in Viral Persistence
Frontiers in Microbiology, 2021 HIV-1 has evolved mechanisms to evade host cell immune responses and persist for lifelong infection. Latent cellular reservoirs are responsible for this persistence of HIV-1 despite the powerful effects of highly active antiretroviral therapies (HAART ...
Chynna M. Hendricks +3 more
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eLife, 2023 HIV-1 infection results in the activation of inflammasome that may facilitate viral spread and establishment of viral reservoirs. We evaluated the effects of the caspase-1 inhibitor VX-765 on HIV-1 infection in humanized NSG mice engrafted with human ...
Mathieu Amand +6 more
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HIV reservoir: antiviral immune responses and immune interventions for curing HIV infection
Chinese Medical Journal, 2022 . Antiretroviral therapy against human immunodeficiency virus (HIV) is effective in controlling viral replication but cannot completely eliminate HIV due to the persistence of the HIV reservoir.
Shuang Li +4 more
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Identification, Quantification, and Characterization of HIV-1 Reservoirs in the Human Brain
Cells, 2022 The major barrier to cure HIV infection is the early generation and extended survival of HIV reservoirs in the circulation and tissues. Currently, the techniques used to detect and quantify HIV reservoirs are mostly based on blood-based assays; however ...
Maribel Donoso +5 more
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Targeting HIV-1 reservoirs in T cell subsets
Frontiers in Immunology, 2023 The HIV-1 reservoirs harbor the latent proviruses that are integrated into the host genome. It is a challenging task to eradicate the proviruses in order to achieve an HIV cure.
Min Li +4 more
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Neutralizing the HIV Reservoir [PDF]
Cell, 2014 Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.
Marsden, Matthew D, Zack, Jerome A
openaire +4 more sources
The Splice of Life: Does RNA Processing Have a Role in HIV-1 Persistence?
Viruses, 2021 Antiretroviral therapy (ART) suppresses HIV-1 replication but does not eradicate the virus. Persistence of HIV-1 latent reservoirs in ART-treated individuals is considered the main obstacle to achieving an HIV-1 cure.
Alexander O. Pasternak, Ben Berkhout
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Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure
Chinese Medical Journal, 2023 . Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li +6 more
doaj +1 more source