Results 21 to 30 of about 48,965 (195)

Tissue reservoirs of HIV [PDF]

Current Opinion in HIV and AIDS, 2016
Tissue reservoirs of HIV may promote the persistent immunopathology responsible for non-AIDS morbidity and data support multifocal reactivation from tissues as the source of viral rebound during antiretroviral therapy (ART) interruption. The heterogeneity of tissue reservoirs and incomplete knowledge about their composition are obstacles to an HIV cure.
Wong, Joseph K, Yukl, Steven A
openaire   +4 more sources

Depletion of HIV reservoir by activation of ISR signaling in resting CD4+ T cells

iScience, 2023
Summary: HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4+ T cell ...
Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang   +12 more
doaj   +1 more source

Epigenetic Mechanisms of HIV-1 Persistence

Vaccines, 2021
Eradicating HIV-1 in infected individuals will not be possible without addressing the persistence of the virus in its multiple reservoirs. In this context, the molecular characterization of HIV-1 persistence is key for the development of rationalized ...
Roxane Verdikt, Olivier Hernalsteens, Carine Van Lint   +2 more
doaj   +1 more source

The reservoir of latent HIV

Frontiers in Cellular and Infection Microbiology, 2022
The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the ...
Jing Chen, Tong Zhou, Yuan Zhang, Shumin Luo, Huan Chen, Dexi Chen, Chuanyun Li, Weihua Li   +7 more
openaire   +3 more sources

Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities

mBio, 2020
HIV reservoirs persist despite successful antiretroviral therapy (ART) and are a major obstacle to the eradication and cure of HIV. The mature monocyte subset, CD14+CD16+, contributes to viral reservoirs and HIV-associated comorbidities. Only a subset of
Rosiris León-Rivera, Brenda Morsey, Meng Niu, Howard S. Fox, Joan W. Berman   +4 more
doaj   +1 more source

IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway

Frontiers in Immunology, 2021
A major barrier to HIV eradication is the persistence of viral reservoirs. Resting CD4+ T cells are thought to be one of the major viral reservoirs, However, the underlying mechanism regulating HIV infection and the establishment of viral reservoir in T ...
Zhuo Wang, Zhuo Wang, Xiaowan Yin, Meichen Ma, Hongchi Ge, Bin Lang, Hong Sun, Sijia He, Sijia He, Yajing Fu, Yu Sun, Xiaowen Yu, Zining Zhang, Hualu Cui, Xiaoxu Han, Junjie Xu, Haibo Ding, Zhenxing Chu, Hong Shang, Yuntao Wu, Yongjun Jiang   +20 more
doaj   +1 more source

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART. [PDF]

, 2014
Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated.
Adamson, Lourdes, Cannavo, Elda, Deere, Jesse D, Higgins, Joanne, Kauffman, Robert C, Luciw, Paul A, North, Thomas W, Schinazi, Raymond F, Villalobos, Andradi   +8 more
core   +5 more sources

HIV RESERVOIR IN HIV PATIENTS

TUBERCULOSIS AND LUNG DISEASES, 2019
An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease. The review presents published data on the structure of HIV reservoir, its formation and change of its size at different stages of the disease, depending on the ...
E. I. Veselova, G. D. Kaminskiy, A. G. Samoylova, I. A. Vasilyeva   +3 more
openaire   +3 more sources

Biomarker reveals HIV's hidden reservoir [PDF]

eLife, 2014
Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV infection.
Leslie R Cockerham, Steven G Deeks
openaire   +4 more sources

Phospholipid Metabolism Is Associated with Time to HIV Rebound upon Treatment Interruption

mBio, 2021
The likelihood of HIV rebound after stopping antiretroviral therapy (ART) is a combination of the size of HIV reservoirs that persist despite ART and the host immunological and inflammatory factors that control these reservoirs.
Leila B. Giron, Emmanouil Papasavvas, Xiangfan Yin, Aaron R. Goldman, Hsin-Yao Tang, Clovis S. Palmer, Alan L. Landay, Jonathan Z. Li, John R. Koethe, Karam Mounzer, Jay R. Kostman, Qin Liu, Luis J. Montaner, Mohamed Abdel-Mohsen   +13 more
doaj   +1 more source