Results 41 to 50 of about 48,965 (195)
Prediction and prevention of the next pandemic zoonosis. [PDF]
, 2012 Most pandemics--eg, HIV/AIDS, severe acute respiratory syndrome, pandemic influenza--originate in animals, are caused by viruses, and are driven to emerge by ecological, behavioural, or socioeconomic changes.
Carroll, Dennis +8 more
core +1 more source
Frontiers in Microbiology, 2020 One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells (“shock” phase) while maintaining antiretroviral therapy (ART) in order
Amina Ait-Ammar +9 more
doaj +1 more source
HIV-1 regulation of latency in the monocyte-macrophage lineage and in CD4+ T lymphocytes. [PDF]
, 2009 peer reviewedThe introduction in 1996 of the HAART raised hopes for the eradication of HIV-1. Unfortunately, the discovery of latent HIV-1 reservoirs in CD4+ T cells and in the monocyte-macrophage lineage proved the optimism to be premature.
Aunis, Dominique +8 more
core +3 more sources
Platelets in HIV: A Guardian of Host Defence or Transient Reservoir of the Virus?
Frontiers in Immunology, 2021 The immune and inflammatory responses of platelets to human immunodeficiency virus 1 (HIV-1) and its envelope proteins are of great significance to both the treatment of the infection, and to the comorbidities related to systemic inflammation.
Etheresia Pretorius
doaj +1 more source
Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents. [PDF]
, 2018 HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination
DeChristopher, Brian A +11 more
core +1 more source
HIV-1 Reservoirs During Suppressive Therapy [PDF]
Trends in Microbiology, 2016 The introduction of antiretroviral therapy (ART) 20 years ago has dramatically reduced morbidity and mortality associated with HIV-1. Initially there was hope that ART would be curative, but it quickly became clear that even though ART was able to restore CD4(+) T cell counts and suppress viral loads below levels of detection, discontinuation of ...
Kirston, Barton +2 more
openaire +2 more sources
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for Establishing Viral Replication Early in Infection. [PDF]
, 2017 Antiviral innate host defenses against acute viral infections include suppression of host protein synthesis to restrict viral protein production.
Clarissa Santos Rocha +9 more
core +2 more sources
A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"? [PDF]
, 2016 With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The
Cannon, Paula M +14 more
core +2 more sources
EBioMedicineSummary: Background: Virus-specific CD8+ T cells play a major role in the natural control of HIV infection, linked to memory-like features such as high survival capacity and polyfunctionality.
Federico Perdomo-Celis +7 more
doaj +1 more source
Microglial Cells: The Main HIV-1 Reservoir in the Brain
Frontiers in Cellular and Infection Microbiology, 2019 Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved.
Clementine Wallet +10 more
doaj +1 more source