IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
BMC Medicine, 2021 Background Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 replication after treatment ...
Zhenhua Zhang +11 more
doaj +1 more source
Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure
Frontiers in Immunology, 2022 Early initiation of antiretroviral therapy (ART) significantly improves clinical outcomes and reduces mortality of infants/children living with HIV. However, the ability of infected cells to establish latent viral reservoirs shortly after infection and ...
Stella J. Berendam +17 more
doaj +1 more source
Safety and preliminary efficacy of vorinostat with R-EPOCH in high-risk HIV-associated non-Hodgkin\u27s lymphoma (AMC-075) [PDF]
, 2018 We performed a phase I trial of vorinostat (VOR) given on days 1 to 5 with R-EPOCH (rituximab plus etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin hydrochloride) in patients with aggressive HIV-associated non-Hodgkin lymphoma.
Aboulafia, David +12 more
core +2 more sources
HIV Persistence in Adipose Tissue Reservoirs [PDF]
Current HIV/AIDS Reports, 2018 The purpose of this review is to examine the evidence describing adipose tissue as a reservoir for HIV-1 and how this often expansive anatomic compartment contributes to HIV persistence.Memory CD4 T cells and macrophages, the major host cells for HIV, accumulate in adipose tissue during HIV/SIV infection of humans and rhesus macaques.
Jacob, Couturier, Dorothy E, Lewis
openaire +2 more sources
Low-Level HIV-I Replication and the Dynamics of the Resting CD4(+) T Cell Reservoir for HIV-I in the Setting of HAART [PDF]
, 2008 In the setting of highly active antiretroviral therapy (HAART), plasma levels of human immunodeficiency type-I (HIV-I) rapidly decay to below the limit of detection of standard clinical assays.
Sedaghat, Ahmad R. +2 more
core +1 more source
Measuring the HIV-1 reservoir [PDF]
Nature Reviews Microbiology, 2019 The description of a method to measure the HIV-1 reservoir that quantifies intact and defective proviruses.
openaire +2 more sources
Mathematical modelling of internal HIV dynamics [PDF]
, 2009 We study a mathematical model for the viral dynamics of HIV in an infected individual in the presence of HAART. The paper starts with a literature review and then formulates the basic mathematical model.
Dalal, Nirav +3 more
core +1 more source
Dolutegravir-based regimen maintains virological success in a patient with archived mutations to integrase inhibitors [PDF]
, 2017 no abstract ...
Falasca, Francesca +3 more
core +1 more source
HIV reservoirs and latency models
Virology, 2011 The main impediment to a cure for HIV is the existence of long-lasting treatment resistant viral reservoirs. In this review, we discuss what is currently known about reservoirs, including their formation and maintenance, while focusing on latently infected CD4+ T cells.
Pace, Matthew J. +3 more
openaire +2 more sources
Establishment of latent HIV-1 reservoirs: what do we really know?
Journal of Virus Eradication, 2019 Despite our ability to suppress HIV-1 replication indefinitely in people on optimal combined antiretroviral therapy (cART), HIV-1 persists as a stably integrated and replication-competent provirus in a heterogeneous collection of long-lived cells (often ...
Jef Vanhamel +2 more
doaj +1 more source