Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus. [PDF]
, 2016 HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion.
DeClercq, Joshua J. +16 more
core +3 more sources
Protein expression from unintegrated HIV-1 DNA introduces bias in primary in vitro post-integration latency models [PDF]
, 2016 To understand the persistence of latently HIV-1 infected cells in virally suppressed infected patients, a number of in vitro models of HIV latency have been developed.
Bonczkowski, Pawel +7 more
core +1 more source
Longitudinal sequencing of HIV-1 infected patients with low-level viremia for years while on ART shows no indications for genetic evolution of the virus [PDF]
, 2017 HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays.
Dauwe, Kenny +7 more
core +1 more source
Long-lived reservoirs of HIV-1 [PDF]
Trends in Microbiology, 2014 HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.
Thomas D, Zaikos, Kathleen L, Collins
openaire +2 more sources
Subtype C HIV-1 reservoirs throughout the body in ART-suppressed individuals
JCI Insight, 2022 Subtype B HIV-1 reservoirs have been intensively investigated, but reservoirs in other subtypes and how they respond to antiretroviral therapy (ART) is substantially less established.
Zhou Liu +4 more
doaj +1 more source
Benefits and limitations of humanized mice in HIV persistence studies
Retrovirology, 2020 Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent virus replication and stop disease progression.
Matthew D. Marsden
doaj +1 more source
Microglial HIV-1 Expression: Role in HIV-1 Associated Neurocognitive Disorders
Viruses, 2021 The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination antiretroviral therapy (cART), remains a critical roadblock for the development of a novel cure strategy for HIV-1.
Hailong Li +4 more
doaj +1 more source
HIV Reservoir Characterization Symposium
Journal of Virus Eradication, 2017 The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir characterisation with a view to achieving an HIV cure.
Eva Malatinkova +3 more
openaire +2 more sources
Hepatitis B virus vaccination in HIV-1-infected young adults: A tool to reduce the size of HIV-1 reservoirs? [PDF]
, 2018 During anti-retroviral therapy (ART) HIV-1 persists in cellular reservoirs, mostly represented by CD4+ memory T cells. Several approaches are currently being undertaken to develop a cure for HIV-1 infection through elimination (or reduction) of these ...
Amu +42 more
core +2 more sources
Heterogeneity of HIV-1 latent reservoirs
Chinese Medical Journal, 2020 Abstract Antiretroviral therapy (ART) can effectively inhibit human immunodeficiency virus-1 (HIV-1) replication, but is not curative due to the existence of a stable viral latent reservoir harboring replication-competent proviruses.
Jia-Cong Zhao +3 more
openaire +3 more sources