Results 71 to 80 of about 48,965 (195)
JCI Insight, 2021 Antiretroviral therapies (ARTs) abrogate HIV replication; however, infection persists as long-lived reservoirs of infected cells with integrated proviruses, which reseed replication if ART is interrupted.
Eva M. Stevenson +23 more
doaj +1 more source
Viruses, 2020 HIV-1 infects 39.5 million people worldwide, and cART is effective in preventing viral spread by reducing HIV-1 plasma viral loads to undetectable levels.
Daniel O. Pinto +12 more
doaj +1 more source
Drivers of disease emergence and spread: Is wildlife to blame? [PDF]
, 2014 The global focus on wildlife as a major contributor to emerging pathogens and infectious diseases (EIDs) in humans and domestic animals is not based on field, experimental or dedicated research, but mostly on limited surveys of literature, opinion and ...
Kock, R A
core +2 more sources
Genetic diversity in the env V1-V2 region of proviral quasispecies from long-term controller MHC-typed cynomolgus macaques infected with SHIVSF162P4cy [PDF]
, 2018 Intra-host evolution of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) has been shown by viral RNA analysis in subjects who naturally suppress plasma viremia to low levels, known as controllers.
Borsetti, Alessandra +11 more
core +1 more source
Barriers for HIV Cure: The Latent Reservoir [PDF]
AIDS Research and Human Retroviruses, 2018 Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in search of vaccines and treatments to eradicate this devastating infectious disease. Progress has been made in understanding the molecular pathogenesis of this infection, which has been crucial for the development of the current therapy regimens. However,
Castro-Gonzalez, Sergio +2 more
openaire +4 more sources
RNA Polymerase III Regulates HIV Replication and Latency
VirusesThe elimination of HIV latent reservoirs is an extremely challenging task due to the interplay of multiple mechanisms regulating latency. Thus, we need to identify novel strategies to target heterogeneous reservoirs uniformly.
Landon Thompson +7 more
doaj +1 more source
JMIR Research Protocols, 2022 BackgroundAntiretroviral therapy (ART) can bring HIV-1 levels in blood plasma to the undetectable level and allow a near-normal life expectancy for HIV-infected individuals. Unfortunately, ART is not curative and must be taken for
Aubin Joseph Nanfack +12 more
doaj +1 more source
Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]
, 2018 Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John +13 more
core +1 more source
Viruses, 2020 In adherent individuals, antiretroviral therapy (ART) suppresses HIV replication, restores immune function, and prevents the development of AIDS. However, ART is not curative and has to be followed lifelong.
Gilles Darcis +2 more
doaj +1 more source
EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. [PDF]
PLoS Pathogens, 2018 Suppression of HIV replication by antiretroviral therapy (ART) or host immunity can prevent AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV-NCI).
Chao-Jiang Gu +13 more
doaj +1 more source