Results 81 to 90 of about 48,965 (195)

Distinguishable topology of the task-evoked functional genome networks in HIV-1 reservoirs

iScience
Summary: HIV-1 reservoirs display a heterogeneous nature, lodging both intact and defective proviruses. To deepen our understanding of such heterogeneous HIV-1 reservoirs and their functional implications, we integrated basic concepts of graph theory to ...
Janusz Wiśniewski, Kamil Więcek, Haider Ali, Krzysztof Pyrc, Anna Kula-Păcurar, Marek Wagner, Heng-Chang Chen   +6 more
doaj   +1 more source

Molecular Understanding of HIV-1 Latency

Advances in Virology, 2012
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis.
W. Abbas, G. Herbein
doaj   +1 more source

Roadblocks to translational challenges on viral pathogenesis. [PDF]

, 2013
Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven, Drosten, Christian, Picker, Louis, Subbarao, Kanta, Suzich, Joann   +4 more
core   +1 more source

Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies

Retrovirology, 2020
The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs
Yash Agarwal, Cole Beatty, Shivkumar Biradar, Isabella Castronova, Sara Ho, Kevin Melody, Moses Turkle Bility   +6 more
doaj   +1 more source

Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. [PDF]

, 2016
HIV targets the gut mucosa early in infection, causing immune and epithelial barrier dysfunction and disease progression. However, gut mucosal sensing and innate immune signaling through mucosal pattern recognition receptors (PRRs) during HIV infection ...
Bäumler, AJ, Dandekar, S, Gaulke, CA, Glavan, TW, Goulart, LR, Hirao, LA, Jiang, G, Raffatellu, M, Sankaran-Walters, S, Santos Rocha, C   +9 more
core   +2 more sources

Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117. [PDF]

, 2018
A clinical trial was performed to evaluate 3BNC117, a potent anti-HIV-1 antibody, in infected individuals during suppressive antiretroviral therapy and subsequent analytical treatment interruption (ATI).
Barton, John P, Belblidia, Shiraz A, Burke, Leah, Butler, Allison L, Caskey, Marina, Cohen, Yehuda Z, Dizon, Juan P, Gulick, Roy M, Jankovic, Mila, Krassnig, Lisa, Lorenzi, Julio CC, Lu, Ching-Lan, Mendoza, Pilar, Millard, Katrina, Nussenzweig, Michel C, Oliveira, Thiago Y, Pai, Joy, Seaman, Michael S, Shimeliovich, Irina, Sleckman, Christopher, Witmer-Pack, Maggi   +20 more
core   +1 more source

Jails and Prisons -- Reservoirs of TB Disease: Should Defendants with HIV Infection (Who Cannot Swim) Be Thrown into the Reservoir? [PDF]

, 1993
The resurgence of tuberculosis (TB) in urban areas has direct and alarming consequences within the criminal justice system. Lock-up facilities, jails and prisons are TB breeding grounds.
Colangelo, Faith, Hogan, Mariana
core   +4 more sources

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

Nature Communications
Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral ...
Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas   +33 more
doaj   +1 more source

Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

Clinical Epigenetics, 2018
HIV-1 latency allows the virus to persist until reactivation, in a transcriptionally silent form in its cellular reservoirs despite the presence of effective cART.
Sheraz Khan, Mazhar Iqbal, Muhammad Tariq, Shahid M. Baig, Wasim Abbas   +4 more
doaj   +1 more source

HIV e reservoir

, 2019
Persistence of transcriptionally silent but replication-competent HIV reservoir in resting CD4+T cells constitutes the major barrier to viral eradication. Small latent reservoirs are associated to a better prognosis and predictive of less likelihood to undergo virological rebound during simplified therapy.
openaire   +2 more sources