Results 31 to 40 of about 1,023 (128)
Berichte zur Wissenschaftsgeschichte, Volume 48, Issue 3, Page 266-289, October 2025.Wie kann man einen historischen Blick auf das eigene Fach werfen? Diese Frage ist nicht einfach zu beantworten – will man einerseits nicht in einer Nabelschau und Hagiographie enden, andererseits aber auch keinen umfassenden Entwurf einer zukünftigen Historiographie vorlegen.
Soraya de Chadarevian +2 more
wiley +1 more source
International Journal of Genomics, Volume 2018, Issue 1, 2018., 2018 Next‐generation sequencing has uncovered novel classes of small RNAs (sRNAs) in eukaryotes, in addition to the well‐known miRNAs, siRNAs, and piRNAs. In particular, sRNA species arise from transcription start sites (TSSs) and the transcription termination sites (TTSs) of genes. However, a detailed characterization of these new classes of sRNAs is still
Ilaria Laudadio +8 more
wiley +1 more source
Hiwi Knockdown Inhibits the Growth of Lung Cancer in Nude Mice
Asian Pacific Journal of Cancer Prevention, 2013 Hiwi, a human homologue of the Piwi family, plays an important role in stem cell self-renewal and is overexpressed in various human tumors. This study aimed to determine whether an RNA interference-based strategy to suppress Hiwi expression could inhibit tumor growth in a xenograft mouse model.
Dong, Liang +6 more
openaire +3 more sources
Use of community characteristics to predict hunting and game harvests in western Amazonian forests
Conservation Biology, Volume 39, Issue 4, August 2025.Abstract Wild game harvesting in Amazonia provides rural residents with protein and cash income but can threaten wildlife populations and forest ecosystem functions. As yet, the socioeconomic and environmental drivers that shape hunter livelihoods remain poorly understood.
Daniel Zayonc +4 more
wiley +1 more source
Immunity, Inflammation and Disease, Volume 12, Issue 6, June 2024.Cancer‐testis antigens (CTAs) exhibit carcinogenic potential and strong immunogenicity in ovarian cancer. This review outlines a comprehensive of overview the regulatory mechanism, immunogenicity, clinical expression significance, tumorigenesis, and application prospects of CTAs in ovarian cancer, all of which can provide novel insights in the ...
Lina Lin +7 more
wiley +1 more source
Suppression of Hiwi inhibits the growth and epithelial-mesenchymal transition of cervical cancer cells. [PDF]
Oncol Lett, 2018 Cervical cancer is a common gynecological malignancy. Hiwi exhibits a high level of expression in cervical cancer cells. However, the effects of Hiwi expression in cervical cancer cells remain unresolved. In the present study, the effects of Hiwi downregulation on the growth and epithelial-mesenchymal transition of cervical cancer cells were ...
Pei G, Li B, Ma A.
europepmc +4 more sources
The role of HIWI in stem cell maintenance and sarcomagenesis.
Journal of Clinical Oncology, 2011 e20500 Background: PIWI proteins comprise a highly conserved protein family that promote genomic integrity during early development via small RNA-mediated gene silencing and DNA methylation-mediate...
S. Siddiqi, M. Terry, I. Matushansky
openaire +2 more sources
Zhongguo shiyan zhenduanxue, 2010 目的评价靶向Hiwi基因的shRNA表达载体的干扰效果。方法通过构建靶向Hiwi基因的短发夹RNA（shout-hairpin RNA,shRNA）真核表达载体pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263,并以pGenesil-2-control为阴性对照,转染膀胱癌T24细胞,从mRNA和蛋白水平观察3种干扰载体的干扰效率。结果pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263组膀胱癌T24细胞Hiwi mRNA与GAPDH灰度比值较Normal ...
陈岐辉 +4 more
doaj
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells [PDF]
International Journal of Cancer, 2005 AbstractStem cell genetics research may be critical to our understanding of carcinogenesis, as both stem cells and cancer cells possess the ability to self‐renew. Recent discoveries have indicated that the piwi family of genes plays an essential role in stem cell self‐renewal in diverse organisms.
Xiaoying, Liu +10 more
openaire +2 more sources
Zhongguo shiyan zhenduanxue, 2008 目的构建靶向HIWI基因的shRNA真核表达载体质粒,为利用RNA干扰技术探索HIWI基因的作用的研究做准备。方法根据HIWI mRNA序列设计并合成shRNA寡核苷酸片段,退火形成双链并连接入pGenesil-2载体,并进行酶切鉴定和测序。结果酶切证明构建的shRNA已插入载体中,经测序证明与设计相同。结论成功构靶向HIWI基因的shRNA真核表达载体,为进一步研究HIWI基因在干细胞和肿瘤细胞中的作用机制及后续的体内外RNAi实验研究奠定了基础。
陈岐辉 +4 more
doaj