Results 21 to 30 of about 1,054 (99)

Elevated P‐Element‐Induced Wimpy‐Testis‐Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers

open access: yesJournal of Oncology, Volume 2021, Issue 1, 2021., 2021
Increasing evidence has shown that overexpression of P‐element‐induced wimpy‐testis (PIWI)‐like protein 1 (PIWIL1) was associated with unfavorable prognosis of patients with various types of cancers. Herein, we conducted this meta‐analysis to identify the clinicopathological and prognostic value of the PIWIL1 expression in cancers.
Kehua Jiang   +7 more
wiley   +1 more source

PIWI expression and function in cancer

open access: yesFrontiers in Genetics, 2012
PIWI proteins, a subclade of the Argonaute family proteins, are expressed predominantly in the germline and bind to PIWI-interacting RNAs (piRNAs), which are 25-31 nucleotides in length. The PIWI/piRNA pathway plays critical roles in germline development
Ryusuke eSuzuki   +2 more
doaj   +1 more source

Reversing Lanmodulin's Metal‐Binding Sequence in Short Peptides Surprisingly Increases the Lanthanide Affinity

open access: yesAngewandte Chemie, Volume 137, Issue 46, November 10, 2025.
Accidentally reversing the lanthanide‐binding sequences of lanmodulin‐inspired short peptides lead to the serendipitous discovery of a set of peptides with a one order of magnitude higher lanthanide‐binding affinity than the uncapped peptides synthesised in the correct direction.
Sophie M. Gutenthaler‐Tietze   +5 more
wiley   +2 more sources

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

open access: yesCell Reports, 2012
Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia, haploid spermatocytes, or spermatids.
Charles A. Easley, IV   +10 more
doaj   +1 more source

Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

open access: yesBMC Cancer, 2012
Background Although the role of microRNA’s (miRNA’s) biogenesis pathway genes in cancer development and progression has been well established, the association between genetic variants of this pathway genes and breast cancer survival is still unknown ...
Sung Hyuna   +10 more
doaj   +1 more source

Wschodnioeuropejscy ochotnicy cudzoziemscy w niemieckich oddziałach Ostheer, SS i policji pacyfikujących Powstanie Warszawskie. Casus „własowców”, Kałmuków i SS Galizien...

open access: yesDzieje Najnowsze, 2015
East European Foreign Volunteers in German Ostheer, SS, and Police Divisions Pacifying the Warsaw Uprising. The Case of the “Vlasovites”, Kalmuks, and SS Galizien… The intention of this article is to bring the reader closer to a little–known aspect of ...
Hubert Kuberski
doaj   +1 more source

Comparison of a 3D‐printed skin model with established methods for teaching punch biopsy with suturing

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background Realistic and accessible models are essential for training physicians in clinical procedures. This study investigated whether a cost‐effective 3D‐printed skin model is superior to fruit and foam models for teaching skin biopsies. Patients and Methods The study (10/2023‐02/2025) involved 148 medical students who compared the 3D skin ...
Sandra Schuh   +5 more
wiley   +1 more source

Vergleich eines 3D‐gedruckten Hautmodells mit etablierten Methoden zur Lehre der Stanzbiopsie mit Nahtversorgung

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Zusammenfassung Hintergrund Realistische Trainingsmodelle sind essenziell, um Ärztinnen und Ärzte in klinischen Prozeduren zu schulen. In dieser Studie wurde untersucht, ob ein kostengünstiges, selbst generiertes 3D‐gedrucktes Hautmodell Früchten und Schaumstoffmodellen beim Erlernen von Hautstanzen überlegen ist.
Sandra Schuh   +5 more
wiley   +1 more source

Humans are not unique: difficult birth is common in placental mammals

open access: yesBiological Reviews, Volume 101, Issue 5, Page 2214-2239, October 2026.
ABSTRACT Human childbirth is widely presumed to be uniquely difficult and dangerous compared to birth in other mammals. Tight fetopelvic proportions can result in obstructed labour and contribute to high rates of maternal and neonatal mortality. Ideas summarised under the ‘obstetrical dilemma’ have contributed to this assumption by explaining difficult
Nicole D. S. Grunstra
wiley   +1 more source

靶向Hiwi基因的shRNA表达载体的干扰效果评价

open access: yesZhongguo shiyan zhenduanxue, 2010
目的评价靶向Hiwi基因的shRNA表达载体的干扰效果。方法通过构建靶向Hiwi基因的短发夹RNA(shout-hairpin RNA,shRNA)真核表达载体pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263,并以pGenesil-2-control为阴性对照,转染膀胱癌T24细胞,从mRNA和蛋白水平观察3种干扰载体的干扰效率。结果pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263组膀胱癌T24细胞Hiwi mRNA与GAPDH灰度比值较Normal ...
陈岐辉   +4 more
doaj  

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