Results 1 to 10 of about 1,066 (136)

Hiwi Mediated Tumorigenesis Is Associated with DNA Hypermethylation [PDF]

PLoS ONE, 2012
Expression of Piwi proteins is confined to early development and stem cells during which they suppress transposon migration via DNA methylation to ensure genomic stability. Piwi's genomic protective function conflicts with reports that its human ortholog,
Igor Matushansky
exaly   +5 more sources

Relationship between the Occurrence of Genetic Variants of Single Nucleotide Polymorphism in microRNA Processing Genes and the Risk of Developing Multiple Sclerosis [PDF]

Biomedicines, 2022
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), which leads to disturbances in the conduction of nerve impulses, cognitive impairment, sensory and motor disturbances, as well as depressive symptoms. MS
Justyna Basak, Danuta Piotrzkowska, Ireneusz Majsterek, Ewa Kucharska   +3 more
doaj   +2 more sources

Co-overexpression of self-renewal markers SALL4 and HIWI is correlated with depth of tumor invasion and metastasis in colorectal cancer

Egyptian Journal of Medical Human Genetics, 2022
Background SALL4 and HIWI are involved in the maintenance of self-renewal capacity of stem cells. Several scrutinizes have demonstrated that SALL4 and HIWI play a key role in cancer development.
Mohammad Mahdi Forghanifard, Forghanifard Mohammad Mahdi   +1 more
exaly   +2 more sources

MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma [PDF]

BMC Cancer, 2020
Background MEIS1 (Myeloid ecotropic viral integration site 1) as a homeobox (HOX) transcription factor plays regulatory roles in a variety of cellular processes including development, differentiation, survival, apoptosis and hematopoiesis, as well as ...
Selma Zargari, Shabnam Negahban Khameneh, Abolfazl Rad, Mohammad Mahdi Forghanifard   +3 more
doaj   +2 more sources

Expression of HIWI in human esophageal squamous cell carcinoma is significantly associated with poorer prognosis [PDF]

BMC Cancer, 2009
Background HIWI, the human homologue of Piwi family, is present in CD34+ hematopoietic stem cells and germ cells, but not in well-differentiated cell populations, indicating that HIWI may play an impotent role in determining or maintaining stemness of ...
Shou Chengcao, Fan Qingxia, Wang Qi, Wang Zhihui, He Wei, Wang Junsheng, Giercksky Karl-Erik, Nesland Jahn M, Suo Zhenhe   +8 more
doaj   +4 more sources

Comparative Binding Studies of the Chelators Methylolanthanin and Rhodopetrobactin B to Lanthanides and Ferric Iron. [PDF]

Chembiochem
The synthesis and the investigation of the lanthanide (Ln) and Fe‐binding properties of the putative lanthanophore methylolanthanin (MLL) and the siderophore rhodopetrobactin B (RPB B) are reported. While both chelators bind Lns, they unexpectedly precipitate with Lns under biologically relevant conditions and thereby challenge the proposed classic ...
Gutenthaler-Tietze SM, Mertens M, Phi MT, Weis P, Drobot B, Köhrer A, Steudtner R, Karst U, Martinez-Gomez NC, Daumann LJ.   +9 more
europepmc   +2 more sources

Overexpression of Hiwi Promotes Growth of Human Breast Cancer Cells [PDF]

Asian Pacific Journal of Cancer Prevention, 2014
The Piwi subfamily comprises two argonaute (Ago) family proteins, which are defined by the presence of PAZ and Piwi domains, with well known roles in RNA silencing. Hiwi, a human Piwi subfamily member, has been shown to play essential roles in stem cell self-renewal and gametogenesis.
Da-Wei, Wang, Zhao-Hui, Wang, Ling-Ling, Wang, Yang, Song, Gui-Zhen, Zhang   +4 more
exaly   +3 more sources

Hiwi Knockdown Inhibits the Growth of Lung Cancer in Nude Mice

Asian Pacific Journal of Cancer Prevention, 2013
Hiwi, a human homologue of the Piwi family, plays an important role in stem cell self-renewal and is overexpressed in various human tumors. This study aimed to determine whether an RNA interference-based strategy to suppress Hiwi expression could inhibit tumor growth in a xenograft mouse model.
Dong, Liang, Min, Dong, Lin-Jie, Hu, Ze-Hui, Fang, Xia, Xu, En-Hui, Shi, Yi-Ju, Yang   +6 more
exaly   +4 more sources

Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas [PDF]

Oncogene, 2002
The piwi family genes are highly conserved during evolution and play essential roles in stem cell self-renewal, gametogenesis, and RNA interference in diverse organisms ranging from Drosophila melanogaster and C. elegans to Arabidopsis. Here we report the molecular characterization of hiwi, a human member of the piwi gene family.
Haifan Lin, Leendert Looijenga, Looijenga Leendert H J   +2 more
exaly   +4 more sources

Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis

Tumor Biology, 2014
Cancer cells have countless behaviors of pluripotent embryonic stem cells and germ line cells, such as unlimited proliferation, self-renewal, and migration. Expression of specific germ line and embryonic genes in tumor cells may be associated with indefinite growth and invasiveness of such cells. Developmental pluripotency factor 2 (DPPA2) and HIWI are
Reza Raeisossadati, Meysam Moghbeli, Mohammad Reza   +2 more
exaly   +3 more sources