Results 31 to 40 of about 1,066 (136)
Silencing HIWI suppresses the growth, invasion and migration of glioma cells
International Journal of Oncology, 2014 The HIWI gene is one of the members of the PIWI gene family that is important for stem cell self‑renewal and expressed highly in certain human tumors. Some studies have demonstrated that HIWI plays a key role in the development of tumors in cervical, colon and liver cancer.
Xiuyu, Wang +7 more
openaire +3 more sources
Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival
BMC Cancer, 2012 Background Although the role of microRNA’s (miRNA’s) biogenesis pathway genes in cancer development and progression has been well established, the association between genetic variants of this pathway genes and breast cancer survival is still unknown ...
Sung Hyuna +10 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.The influence of head‐to‐tail cyclization, as well as the effect of ring expansion with an additional glycine on lanmodulin‐inspired peptides on the structure and lanthanide (Ln)‐binding behavior was investigated. While the decrease of structural flexibility can indeed increase the Ln affinity and peptide pre‐organization, it does not lead to an ...
Sophie M. Gutenthaler‐Tietze +6 more
wiley +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background Realistic and accessible models are essential for training physicians in clinical procedures. This study investigated whether a cost‐effective 3D‐printed skin model is superior to fruit and foam models for teaching skin biopsies. Patients and Methods The study (10/2023‐02/2025) involved 148 medical students who compared the 3D skin ...
Sandra Schuh +5 more
wiley +1 more source
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells [PDF]
International Journal of Cancer, 2005 AbstractStem cell genetics research may be critical to our understanding of carcinogenesis, as both stem cells and cancer cells possess the ability to self‐renew. Recent discoveries have indicated that the piwi family of genes plays an essential role in stem cell self‐renewal in diverse organisms.
Xiaoying, Liu +10 more
openaire +2 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Zusammenfassung Hintergrund Realistische Trainingsmodelle sind essenziell, um Ärztinnen und Ärzte in klinischen Prozeduren zu schulen. In dieser Studie wurde untersucht, ob ein kostengünstiges, selbst generiertes 3D‐gedrucktes Hautmodell Früchten und Schaumstoffmodellen beim Erlernen von Hautstanzen überlegen ist.
Sandra Schuh +5 more
wiley +1 more source
British Journal of Social Psychology, Volume 65, Issue 4, October 2026.Abstract The impassioned advocacy both for and against Indigenous rights in recent years suggests a polarization of public opinion. Accordingly, we theorize increasingly divided endorsement of two ideologies that challenge Indigenous rights to material and symbolic equality—historical negation and symbolic exclusion, respectively (the ‘Dark Duo ...
Zoe Bertenshaw +2 more
wiley +1 more source
American Journal of Biological Anthropology, Volume 190, Issue 3, July 2026.ABSTRACT Objectives The grandmother hypothesis proposes that ancestral women ceased reproduction midlife to instead provision their grandchildren. An alternative “two‐sex” account proposes that the high energetic burden of caring for slow‐developing offspring was met with biparental investment.
Edward H. Hagen
wiley +1 more source
Zhongguo shiyan zhenduanxue, 2010 目的评价靶向Hiwi基因的shRNA表达载体的干扰效果。方法通过构建靶向Hiwi基因的短发夹RNA（shout-hairpin RNA,shRNA）真核表达载体pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263,并以pGenesil-2-control为阴性对照,转染膀胱癌T24细胞,从mRNA和蛋白水平观察3种干扰载体的干扰效率。结果pGenesil-2-Hiwi1和pGenesil-2-Hiwi2263组膀胱癌T24细胞Hiwi mRNA与GAPDH灰度比值较Normal ...
陈岐辉 +4 more
doaj
Zhongguo shiyan zhenduanxue, 2008 目的构建靶向HIWI基因的shRNA真核表达载体质粒,为利用RNA干扰技术探索HIWI基因的作用的研究做准备。方法根据HIWI mRNA序列设计并合成shRNA寡核苷酸片段,退火形成双链并连接入pGenesil-2载体,并进行酶切鉴定和测序。结果酶切证明构建的shRNA已插入载体中,经测序证明与设计相同。结论成功构靶向HIWI基因的shRNA真核表达载体,为进一步研究HIWI基因在干细胞和肿瘤细胞中的作用机制及后续的体内外RNAi实验研究奠定了基础。
陈岐辉 +4 more
doaj