Results 1 to 10 of about 206,002 (249)

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis [PDF]

RMD Open, 2023
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj   +3 more sources

Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression [PDF]

BMC Immunology, 2023
Background HLA-B27 positivity is normal in patients undergoing rheumatic diseases. The diagnosis of many diseases requires an HLA-B27 examination. Methods This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function ...
Jichong Zhu, Weiming Tan, Xinli Zhan, Qing Lu, Tuo Liang, JieJiang, Hao Li, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Yuanlin Yao, Shian Liao, Chaojie Yu, Liyi Chen, Chong Liu   +14 more
doaj   +2 more sources

Disease characteristics of HLA-B27 positive and negative finnish patients with juvenile idiopathic arthritis - results of the 18-year cohort follow-up study [PDF]

Pediatric Rheumatology Online Journal, 2023
Background The aim of this long-term follow-up study was to compare the disease characteristics of HLA-B27 positive and negative patients with juvenile idiopathic arthritis (JIA).
Suvi Oili Orvokki Peltoniemi, Mia Glerup, Pekka Lahdenne, Kari K Eklund, Kristiina Aalto   +4 more
doaj   +2 more sources

TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis [PDF]

Arthritis Research & Therapy
Background Association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years, but still remains unexplained. We recently showed that HLA-B27 expressed in wing imaginal disc from HLA-B27/human-β2 microglobulin (hβ2m) transgenic Drosophila ...
Marc Lauraine, Maxence de Taffin de Tilques, Dganit Melamed-Kadosh, Bilade Cherqaoui, Vincent Rincheval, Erwan Prevost, Aurore Rincheval-Arnold, Eneida Cela, Arie Admon, Isabelle Guénal, Luiza M. Araujo, Maxime Breban   +11 more
doaj   +2 more sources

Clinical Impact of HLA‐B27 on Juvenile Idiopathic Arthritis: Eighteen Years of Follow‐up in the Population‐Based Nordic Juvenile Idiopathic Arthritis Cohort [PDF]

ACR Open Rheumatology
Objective We have previously shown that HLA‐B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA).
Maria Ekelund, Agnes Szentpetery, Ellen D. Arnstad, Kristiina Aalto, Anders Fasth, Mia Glerup, Troels Herlin, Charlotte Myrup, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Veronika Rypdal, Lillemor Berntson   +12 more
doaj   +2 more sources

HLA-B27 status and inflammatory MRI lesions of the sacroiliac joints: a post hoc analysis in patients without axial spondyloarthritis [PDF]

RMD Open, 2023
Objective The assessment of inflammatory and structural lesions in the sacroiliac joint (SIJ) is crucial in axial spondyloarthritis (axSpA). HLA-B27 status plays an important role in axSpA diagnosis and has been linked to MRI lesion burden in the general
Denis Poddubnyy, Torsten Diekhoff, Sevtap Tugce Ulas, Fabian Proft, Valeria Rios Rodriguez, Judith Rademacher, Katharina Ziegeler   +6 more
doaj   +2 more sources

Expanding the Genetic Framework: Insights into Non-HLA-B27 Contributions to Axial Spondylarthritis [PDF]

Medicina
Background and Objectives: Spondylarthritis is a complex group of inflammatory diseases closely associated with the HLA-B27 antigen. However, the role of non-HLA-B27 alleles in the disease’s pathogenesis has gained significant scholarly attention in ...
Ruxandra-Elena Nagit, Ioana Bratoiu, Corina Cianga, Mariana Pavel-Tanasa, Elena Rezus, Petru Cianga   +5 more
doaj   +2 more sources

The Clinical Characteristics of Other HLA-B Types in Chinese Ankylosing Spondylitis Patients

Frontiers in Medicine, 2021
HLA-B27 has an established relationship with the development of ankylosing spondylitis (AS). After reviewing the HLA-B genotype from 407 Chinese subjects (318 patients and 89 sex-matched controls), we found that 252 patients and 32 controls were HLA-B27(+
Xinyu Wu, Jialing Wu, Xiaomin Li, Qiujing Wei, Qing Lv, Pingping Zhang, Xuqi Zheng, Zena Chen, Shuangyan Cao, Liudan Tu, Jieruo Gu   +10 more
doaj   +1 more source

HLA-B27 is associated with reduced disease activity in axial spondyloarthritis

Scientific Reports, 2021
HLA-B27 is associated with increased susceptibility and disease activity of ankylosing spondylitis, but the effect of HLA-B27 on the activity of the broader category now called axial spondyloarthritis (AxSpA) is apparently the opposite.
James T. Rosenbaum, Michael H. Weisman, Hedley Hamilton, Cassie Shafer, Elin Aslanyan, Richard A. Howard, Kimberly Ogle, John D. Reveille, Kevin L. Winthrop, Dongseok Choi   +9 more
doaj   +1 more source

Targeted delivery of an antigenic peptide to the endoplasmic reticulum: application for development of a peptide therapy for ankylosing spondylitis. [PDF]

PLoS ONE, 2013
The development of suitable methods to deliver peptides specifically to the endoplasmic reticulum (ER) can provide some potential therapeutic applications of such peptides.
Hui-Chun Yu, Ming-Chi Lu, Chin Li, Hsien-Lu Huang, Kuang-Yung Huang, Su-Qin Liu, Ning-Sheng Lai, Hsien-Bin Huang   +7 more
doaj   +1 more source