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Annals of Internal Medicine, 1980
Excerpt To the editor: It is unfortunate that Dr. Calin detracts from his many excellent contributions on the importance of the HLA system in rheumatic disease (1) by concluding his recent article,...
D L, Smith, M G, Regan
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Excerpt To the editor: It is unfortunate that Dr. Calin detracts from his many excellent contributions on the importance of the HLA system in rheumatic disease (1) by concluding his recent article,...
D L, Smith, M G, Regan
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Joint Bone Spine, 2001
HLA-B27 is a serologic specificity that encompasses 25 different alleles that encode 23 different products (proteins): HLA-B*2701 to B*2723. These alleles are also called subtypes of HLA-B27, and they may have evolved from the most widespread subtype, B*2705.
E J, Ball, M A, Khan
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HLA-B27 is a serologic specificity that encompasses 25 different alleles that encode 23 different products (proteins): HLA-B*2701 to B*2723. These alleles are also called subtypes of HLA-B27, and they may have evolved from the most widespread subtype, B*2705.
E J, Ball, M A, Khan
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Clinical Rheumatology, 1996
Most HLA-B27 positive individuals live without noticing the risk factor they carry. Only when certain bacteria come into play, usually in the form of intestinal or genital infection, some of the HLA-B27 positive individuals will develop a reactive disease.
J, Uksila, P, Toivanen
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Most HLA-B27 positive individuals live without noticing the risk factor they carry. Only when certain bacteria come into play, usually in the form of intestinal or genital infection, some of the HLA-B27 positive individuals will develop a reactive disease.
J, Uksila, P, Toivanen
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HLA-B27 Associated Arthropathies
Radiology, 1978The association between histo-compatibility antigens and disease is reviewed, in particular that between HLA-B27 and spondylitic disorders, i.e., ankylosing spondylitis, Reiter's arthritis, psoriatic arthritis, and ankylosing hyperostosis. We determined whether the presence of HLA-B27 predicted specific radiographic findings and, conversely, whether ...
T M, Schumacher +4 more
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Scandinavian Journal of Rheumatology, 1990
Every HLA antigen, as defined by the WHO-HLA Nomenclature, is unique. The major function of these molecules is to present antigen-peptides to the T-cell receptor, thereby contributing to the immunological defence mechanism. This function is regulated for each MHC antigen by its unique structure, with the peptide-binding pockets of the three-dimensional
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Every HLA antigen, as defined by the WHO-HLA Nomenclature, is unique. The major function of these molecules is to present antigen-peptides to the T-cell receptor, thereby contributing to the immunological defence mechanism. This function is regulated for each MHC antigen by its unique structure, with the peptide-binding pockets of the three-dimensional
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Immunogenetics, HLA-B27 and spondyloarthropathies
Current Opinion in Rheumatology, 1999HLA-B27 is the strongest HLA molecule associated with a disease. However, the reason only a small fraction of HLA-B27 positive individuals develop spondyloarthropathies is still unknown. Recent advances in genetics support the fact that additional genetic factors influence the disease and that the environmental factors may be ubiquitous.
S, González +2 more
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Rheumatology, 1988
The various subtypes of HLA-B27 are described together with their worldwide distribution. None is uniquely related to AS but the evidence favours a direct role for B27 in the disease pathogenesis.
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The various subtypes of HLA-B27 are described together with their worldwide distribution. None is uniquely related to AS but the evidence favours a direct role for B27 in the disease pathogenesis.
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Neutrophil Function and HLA-B27
Rheumatology, 1983The pathogenesis of HLA-B27 linked diseases, including reactive enteroarthritides, is not known. Differences in immune response, cross-reaction between microbial antigens and host cell structures, attachment of microbial components on the host cell surfaces with subsequent autoimmune reaction, and inflammatory responsiveness of the host may be involved.
H, Repo +8 more
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