Results 1 to 10 of about 223,968 (292)

Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis [PDF]

RMD Open, 2023
The human lymphocyte antigen B27 (HLA B27) is a member of the HLA class I family of genes in the major histocompatibility complex whose name goes back to its discovery in studies of transplanted tissue compatibility.
Joachim Sieper, Juergen Braun
doaj   +3 more sources

Impact of HLA-B27 and Disease Status on the Gut Microbiome of the Offspring of Ankylosing Spondylitis Patients

Children, 2022
Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities.
Matthew L. Stoll, Kimberly DeQuattro, Zhixiu Li, Henna Sawhney, Pamela F. Weiss, Peter A. Nigrovic, Tracey B. Wright, Kenneth Schikler, Barbara Edelheit, Casey D. Morrow, John D. Reveille, Matthew A. Brown, Lianne S. Gensler   +12 more
doaj   +2 more sources

Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]

, 2020
The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard, Rückert, Christine, Uchanska-Ziegler, Barbara, Ziegler, Andreas   +3 more
core   +3 more sources

Human leukocyte antigen B polymorphism and association between HLA‐B27 and endoplasmic reticulum aminopeptidase 1 rs30187 SNP in patients with ankylosing spondylitis in Bangladesh [PDF]

Rheumatology & Autoimmunity, 2022
Objectives To determine the association of Human leukocyte antigen B (HLA‑B) alleles with ankylosing spondylitis and the allelic association of HLA‐B27 with endoplasmic reticulum aminopeptidase 1 (ERAP1) single‐nucleotide polymorphism (SNP) rs30187 in ...
Md Kamrul H. Sajib, Shamim Ahmed, Syed A. Haq, Minhaj R. Choudhury, Mohammed Uddin, Furkan Uddin, Muhammad S. A. Khan, Mohammad M. Zaman   +7 more
doaj   +2 more sources

Development and validation of a machine learning-based nomogram for predicting HLA-B27 expression [PDF]

BMC Immunology, 2023
Background HLA-B27 positivity is normal in patients undergoing rheumatic diseases. The diagnosis of many diseases requires an HLA-B27 examination. Methods This study screened totally 1503 patients who underwent HLA-B27 examination, liver/kidney function ...
Jichong Zhu, Weiming Tan, Xinli Zhan, Qing Lu, Tuo Liang, JieJiang, Hao Li, Chenxing Zhou, Shaofeng Wu, Tianyou Chen, Yuanlin Yao, Shian Liao, Chaojie Yu, Liyi Chen, Chong Liu   +14 more
doaj   +2 more sources

Does HLA-B27 Status Influence Ixekizumab Efficacy in Axial Spondyloarthritis? Results From the COAST-V, COAST-W, and COAST-X Trials [PDF]

Rheumatology and Therapy
Introduction The human leukocyte antigen (HLA)-B27 is associated with axial spondyloarthritis (axSpA) and is a predictor of response to tumor necrosis factor inhibitors. However, limited data are available on HLA-B27 and interleukin-17 inhibitors.
John D. Reveille, Martin Rudwaleit, Proton Rahman, Jose A. Maldonado-Cocco, Marina Magrey, Rebecca Bolce, Khai Jing Ng, Theresa Hunter Gibble, Jeffrey Lisse, So Young Park, Andris Kronbergs, Victoria Navarro-Compán   +11 more
doaj   +2 more sources

Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients

Frontiers in Medicine, 2020
Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA ...
Shangzhu Zhang, Yanhong Wang, Linyi Peng, Jinmei Su, Xiaofeng Zeng, Mengtao Li, Zhenbiao Wu, Jian Xu, Min Yang, Lijun Wu, Cheng Zhao, Xinwang Duan, Qin Li, Jing Zhu, Wenqiang Fan   +14 more
doaj   +2 more sources

The Phenotype of Axial Spondyloarthritis: Is It Dependent on HLA–B27 Status?

Arthritis care & research, 2020
To describe the radiographic phenotype of axial spondyloarthritis (SpA) according to the presence of HLA–B27.
L. Coates, X. Baraliakos, F. Blanco, E. Blanco-Morales, J. Braun, V. Chandran, J. Fernández-Sueiro, O. FitzGerald, P. Gallagher, D. Gladman, E. Gubar, T. Korotaeva, E. Loginova, E. Lubrano, J. Mulero, J. Pinto-Tasende, R. Queiró, J. Sanz Sanz, A. Szentpetery, P. Helliwell   +19 more
semanticscholar   +3 more sources

Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy

Frontiers in Immunology, 2021
Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the
Tejpal Gill, James T. Rosenbaum, James T. Rosenbaum   +2 more
doaj   +2 more sources

Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

Arthritis Research & Therapy, 2018
Objective To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed.
Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes, Pilar Font, REGISPONSER group   +11 more
doaj   +2 more sources