Results 101 to 110 of about 223,968 (292)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

A Review of Ankylosing Spondylitis [PDF]

, 2017
Ankylosing spondylitis (AS) is a systemic autoimmune disorder that induces ankylosis of the spine (fusion of the vertebrae at their various joints) and inflammatory arthritis of peripheral joints among other symptoms.
Owen, Hannah L
core   +1 more source

Spondyloarthritis: Matrix Metalloproteinasesas Biomarkers of Pathogenesis and Response to Tumor Necrosis Factor (TNF) Inhibitors [PDF]

, 2017
The term spondyloarthritis (SpA) is used to describe a group of multifactorial chronic inflammatory diseases characterized by a predisposing genetic background and clinical manifestations typically involving the sacroiliac joint.
Ada Aita, Breban, Daniela Basso, Giovannini, Leonardo Punzi, Maksymowych, Mario Plebani, Massova, Parma, Roberta Ramonda, Stefania Moz, Woo   +11 more
core   +1 more source

Retrospective analysis of cutaneous immune‐related adverse events following checkpoint inhibitor therapy in melanoma patients reveals increased risk associated with the HLA‐B*51:01 allele

Cancer, Volume 132, Issue 3, 1 February 2026.
ABSTRACT Background While immune checkpoint inhibitors (ICIs) have shown significant efficacy, a common side effect is cutaneous immune‐related adverse events (irAEs). This study focuses on exploring the association between specific human leukocyte antigen (HLA) alleles and the development of cutaneous irAEs in melanoma patients undergoing ICI ...
Mckenzie DiLeo, Samantha Oglesby, Cheuk Hong Leung, Kristen E. Pauken, Sahira Farooq, Lauren E. Haydu, Shelby L. Kubicki, Rebeca Martinez, Macartney Welborn, Sana Zahiruddin, Jun Zou, Kai Cao, Anisha B. Patel   +12 more
wiley   +1 more source

HLA Class I or Class II and Disease Association: Catch the Difference if You Can [PDF]

, 2017
The association of autoimmune diseases with HLA has been known for many decades. To date, however, the underlying mechanisms have not been fully understood. The recently introduced genome-wide association studies (GWAS) have suggested that several genes
Fiorillo, Mt, Paladini, F, Sorrentino, R., Tedeschi, V   +3 more
core   +2 more sources

Precision medicine in orthopaedics: A review of current technologies and future directions

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 2, Page 633-639, February 2026.
Abstract Purpose To synthesise the paradigm shift towards precision medicine in orthopaedics, where individual anatomical, biomechanical, molecular and kinematic characteristics are integrated into clinical decision‐making. Unlike traditional approaches applying uniform protocols, this review outlines how precision orthopaedics aims to tailor surgical ...
Patrick Sadoghi, Amir Koutp, Elmar Herbst, Giuseppe Milano, Volker Musahl, Michael T. Hirschmann   +5 more
wiley   +1 more source

Progression and topographic subtypes of Terrien marginal degeneration

Acta Ophthalmologica, Volume 104, Issue 1, Page 33-43, February 2026.
Abstract Purpose To report long‐term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD). Methods Retrospective, in part prospective, hospital‐based longitudinal follow‐up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow‐up was 7.3 years (range, 0.3–15.2).
Minna Ruutila, Pauliina Repo, Annamari T. Immonen, Joni A. Turunen, Marja‐Liisa Lokki, A. Inkeri Lokki, Jukka Moilanen, Kari Krootila, Tero T. Kivelä   +8 more
wiley   +1 more source

HLA-B27 Frequency and Clinical Correlates in Turkish Patients with Various Subtypes of Spondyloarthritis: A Single-Center Cohort Study

Namık Kemal Tıp Dergisi
Aim: This study aimed to evaluate the frequency of human leukocyte antigen (HLA)-B27 positivity and its clinical correlations in Turkish patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated ...
Dilara BULUT GÖKTEN, Hilmi TOZKIR, Ömer Atakan SOĞUR, Rıdvan MERCAN   +3 more
doaj   +1 more source

Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols [PDF]

, 2009
Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available.
Baron, A., Bigagli, E., Caderni, G., Castagnini, C., Dolara, P., Eijssen, L., Evelo, C., Femia, A.P., Gaj, S., Giovannelli, L., Lodovici, M., Luceri, C., Martin, R., Messerini, L., Pitozzi, V., Renard, C.M., Salvadori, M., Toti, S., Zoetendal, E.G.   +18 more
core   +3 more sources

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats

Journal of Experimental Medicine, 1994
A number of inflammatory disease states occur with greatly increased frequency in individuals inheriting the human major histocompatibility complex class I allele HLA-B27. In a minority of cases, namely those with B27-associated reactive arthritis, there
J. Taurog, J. Richardson, JoAnne T. Croft, W. Simmons, W. Simmons, Ming Zhou, Ming Zhou, J. Fernández-Sueiro, E. Balish, R. Hammer   +9 more
semanticscholar   +1 more source