Results 11 to 20 of about 206,002 (249)
Children, 2022 Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities.
Matthew L. Stoll +12 more
doaj +2 more sources
Frontiers in Medicine, 2020 Objective: The aim of our study was to assess the influence of the HLA-B27 status on axial spondyloarthritis (axSpA) in the largest cohort in China.Methods: An observational, cross-sectional, and analytic study of axSpA patients from the China axSpA ...
Shangzhu Zhang +14 more
doaj +2 more sources
Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy
Frontiers in Immunology, 2021 Spondyloarthritis (SpA) is a group of immune mediated inflammatory diseases with a strong association to the major histocompatibility (MHC) class I molecule, HLA-B27. Although the association between HLA-B27 and AS has been known for almost 50 years, the
Tejpal Gill +2 more
doaj +2 more sources
Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database
Arthritis Research & Therapy, 2018 Objective To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. Method An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed.
Marta Arévalo +11 more
doaj +2 more sources
BMC Musculoskeletal Disorders, 2017 Background Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population.
Nelly Raymond Ziade
doaj +2 more sources
T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis. [PDF]
Curr Rheumatol Rep, 2022 Ankylosing spondylitis (AS) is strongly associated with the HLA-B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 lymphocytes, leading to adaptive immune responses.
Garrido-Mesa J, Brown MA.
europepmc +2 more sources
HLA-B27 typing in the categorisation of uveitis in a HLA-B27 rich population [PDF]
British Journal of Ophthalmology, 2000 To determine whether HLA-B27 typing helps the clinician in the diagnostic examination of uveitis in a HLA-B27 rich population and also whether the clinical picture of HLA-B27 positive unilateral acute or recurrent anterior uveitis (AAU) is distinguishable from the idiopathic negative form.During a 3 year period 220 consecutive patients with ...
M Huhtinen
openalex +5 more sources
Recent Developments in HLA B27 Anterior Uveitis
Frontiers in Immunology, 2021 There has been steady progress in understanding the pathogenesis, clinical features, and effective treatment of acute anterior uveitis (AU) over the past 5 years.
D. Wakefield, D. Clarke, P. McCluskey
semanticscholar +1 more source
Molecular Biology of the HLA-B27 Locus [PDF]
Rheumatology, 1988 The molecular biology of the HLA-B27 locus is reviewed. The HLA-B27 gene itself does not differ between healthy individuals and ankylosing spondylitis patients. Several unique features of the HLA-B27 molecule have been identified and one epitope was proposed to cross-react with bacterial proteins.
E. H. Weiss +7 more
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Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
eLife, 2021 Uveitis describes a heterogeneous group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. Uveitis associated with the HLA haplotype B27 (HLA-B27) is a common subtype of uveitis and a prototypical ocular ...
M. Kasper +11 more
semanticscholar +1 more source