Results 11 to 20 of about 223,968 (292)

No evidence for a direct role of HLA-B27 in pathological bone formation in axial SpA [PDF]

RMD Open, 2017
The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. HLA-B27 positivity is possibly associated with severity of ankylosis.
Kollnberger, Simon, Lories, Rik, Neerinckx, Barbara, Shaw, Jacqueline   +3 more
core   +3 more sources

TGFβ signaling pathway is altered by HLA-B27 expression, resulting in pathogenic consequences relevant for spondyloarthritis [PDF]

Arthritis Research & Therapy
Background Association of HLA-B27 with spondyloarthritis (SpA) has been known for 50 years, but still remains unexplained. We recently showed that HLA-B27 expressed in wing imaginal disc from HLA-B27/human-β2 microglobulin (hβ2m) transgenic Drosophila ...
Marc Lauraine, Maxence de Taffin de Tilques, Dganit Melamed-Kadosh, Bilade Cherqaoui, Vincent Rincheval, Erwan Prevost, Aurore Rincheval-Arnold, Eneida Cela, Arie Admon, Isabelle Guénal, Luiza M. Araujo, Maxime Breban   +11 more
doaj   +2 more sources

Added Value of Anti-CD74 Autoantibodies in Axial SpondyloArthritis in a Population With Low HLA-B27 Prevalence [PDF]

Frontiers in Immunology, 2019
Axial spondyloarthritis (axSpA) is often diagnosed late due to the non-specific nature of its main symptom [chronic back pain (CBP)] and to the paucity of diagnostic markers, particularly in regions with low HLA-B27 prevalence, such as the Middle-East ...
N. Ziadé, I. Mallak, G. Merheb, P. Ghorra, N. Baerlecken, T. Witte, X. Baraliakos   +6 more
semanticscholar   +2 more sources

THE ASSOCIATION OF ERAP2 GENE POLYMORPHISMS WITH SERONEGATIVE SPONDYLOARTHROPATHIES IN HLA-B27 NEGATIVE ROMANIANS [PDF]

Romanian Journal of Rheumatology, 2016
Objective. Our aim was to investigate whether two ERAP2 single nucleotide polymorphisms (rs2910686 and rs2248374) influence spondyloarthritis (SpA) susceptibility in Romanians. Methods.
Laura Ioana Cherciu, Marius Cherciu, Luis Ovidiu Popa, Mihai Bojinca, Monica Irina Dutescu, Violeta Bojinca, Constantin Bara, Olivia Mihaela Popa   +7 more
doaj   +2 more sources

Clinical Impact of HLA‐B27 on Juvenile Idiopathic Arthritis: Eighteen Years of Follow‐up in the Population‐Based Nordic Juvenile Idiopathic Arthritis Cohort [PDF]

ACR Open Rheumatology
Objective We have previously shown that HLA‐B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA).
Maria Ekelund, Agnes Szentpetery, Ellen D. Arnstad, Kristiina Aalto, Anders Fasth, Mia Glerup, Troels Herlin, Charlotte Myrup, Ellen Nordal, Suvi Peltoniemi, Marite Rygg, Veronika Rypdal, Lillemor Berntson   +12 more
doaj   +2 more sources

HLA B27 antigen in Middle Eastern and Arab countries: systematic review of the strength of association with axial spondyloarthritis and methodological gaps

BMC Musculoskeletal Disorders, 2017
Background Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population.
Nelly Raymond Ziade
doaj   +2 more sources

Expanding the Genetic Framework: Insights into Non-HLA-B27 Contributions to Axial Spondylarthritis [PDF]

Medicina
Background and Objectives: Spondylarthritis is a complex group of inflammatory diseases closely associated with the HLA-B27 antigen. However, the role of non-HLA-B27 alleles in the disease’s pathogenesis has gained significant scholarly attention in ...
Ruxandra-Elena Nagit, Ioana Bratoiu, Corina Cianga, Mariana Pavel-Tanasa, Elena Rezus, Petru Cianga   +5 more
doaj   +2 more sources

The Associations of rs1799724 and rs361525 With the Risk of Ankylosing Spondylitis Are Dependent on HLA-B27 Status in a Chinese Han Population

Frontiers in Immunology, 2022
ObjectivesHuman leucocyte antigen B27 (HLA-B27) is an important biomarker for ankylosing spondylitis (AS). However, delay in the diagnosis of AS is still common in clinical practice.
Nan Sheng, Nan Sheng, Nan Sheng, Yingying Gao, Hui Li, Wenwen Wang, Linyu Geng, Bo Zhang, Qiang Huang, Xueqin Wang, Lingyun Sun   +10 more
doaj   +2 more sources

Clinical characterization of patients with HLA-B27-associated uveitis and evaluation of the impact of systemic treatment on the recurrence rate: a cross-sectional study. [PDF]

J Ophthalmic Inflamm Infect, 2023
Pineda-Sierra JS, Cifuentes-González C, Rojas-Carabali W, Muñoz-Vargas PT, Henao-Posada A, de-la-Torre A.   +5 more
europepmc   +3 more sources

HLA-B27, Mantoux Test, and Eosinophil Count: Help in the Diagnosis of Reactive Arthritis Due to Tubercular Hypersensitivity. [PDF]

Cureus
Makkar A, Pai VS, Panda PK.
europepmc   +3 more sources