Results 51 to 60 of about 206,002 (249)
Phosphorylation of STAT-1 serine 727 is prolonged in HLA-B27-expressing human monocytic cells. [PDF]
PLoS ONE, 2013 A tissue antigen, HLA-B27, is strongly associated with a group of rheumatic diseases called spondyloarthritides. Despite the intensive research, the exact role of HLA-B27 in the pathogenesis of these diseases is still unclear. Here we studied whether HLA-
Marja Ruuska +3 more
doaj +1 more source
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
wiley +1 more source
Frontiers in Immunology, 2019 Axial spondyloarthritis (axSpA) is often diagnosed late due to the non-specific nature of its main symptom [chronic back pain (CBP)] and to the paucity of diagnostic markers, particularly in regions with low HLA-B27 prevalence, such as the Middle-East ...
N. Ziadé +6 more
semanticscholar +1 more source
Mediators of Inflammation, 2018 Background and Objectives Spondyloarthritis (SpA) represents a heterogeneous group of immune-mediated inflammatory diseases that have overlapping clinical features, genetic predisposition, and pathogenic mechanisms. Hence, we investigated, through a case-
M. A. Rocha Loures +9 more
semanticscholar +1 more source
Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance
Advanced Science, EarlyView.Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai +5 more
wiley +1 more source
Anais Brasileiros de Dermatologia, 2012 BACKGROUND: HLA-B27 is associated with spondyloarthritis, a group of diseases that includes psoriatic arthritis. OBJECTIVES: To describe the HLA-B27 frequency in a group of Brazilian patients with psoriatic arthritis and correlate its presence or absence
Danilo Garcia Ruiz +2 more
doaj +1 more source
RMD Open, 2020 Objective To determine the association between endoplasmic reticulum aminopeptidase (ERAP)1 and ERAP2 single-nucleotide polymorphisms (SNPs) and human leukocyte antigens (HLA)-B27+ or HLA-B15+ patients with spondyloarthritis (SpA).Methods 104 patients ...
Ruben Burgos-Vargas +16 more
doaj +1 more source
Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27
Frontiers in Immunology, 2022 Ankylosing spondylitis (AS) belongs to a group of diseases, called spondyloarthropathies (SpA), that are strongly associated with the genetic marker HLA-B27. AS is characterized by inflammation of joints and primarily affects the spine. Over 160 subtypes
Amit Kumar Thakur +1 more
doaj +1 more source
Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis
Arthritis &Rheumatology, Accepted Article.Objective Psoriatic arthritis (PsA) is an HLA class I‐associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T‐cell phenotype and clonality.
Lucy E. Durham +14 more
wiley +1 more source
Human Leukocyte Antigen B27‐Negative Axial Spondyloarthritis: What Do We Know?
ACR Open Rheumatology, 2023 Axial spondyloarthritis (axSpA) is a chronic, immune‐mediated disease characterized by inflammatory axial skeleton involvement and extra‐musculoskeletal manifestations.
Atul Deodhar, Tejpal Gill, Marina Magrey
doaj +1 more source