Os sintomas articulares constituem a manifestação extra-intestinal mais comum em pacientes com doença de Crohn e com retocolite ulcerativa. Reconhecida como artrite colítica, e mais recentemente, artrite enteropática, está classificada como uma das ...
Cristina Costa Duarte Lanna+3 more
doaj +1 more source
Objective To assess the development of extramusculoskeletal manifestations (EMMs) among patients with psoriatic arthritis (PsA) or axial spondyloarthritis (axSpA) treated with upadacitinib 15 mg. Methods Data (cutoff: August 15, 2022) from five clinical trials in PsA (2), radiographic axSpA (r‐axSpA; previously ankylosing spondylitis) (2), and ...
Denis Poddubnyy+11 more
wiley +1 more source
CLINICAL COURSE OF JUVENILE IDIOPATHIC ARTHRITIS IN HLA-B27-POSITIVE PATIENTS IN ADULTHOOD
Relevance. The existence of associations between histocompatibility antigens and JIA variants has been proved. There is no consensus that the JIAs associated with HLA-B27 antigen are transformed in adulthood into other diseases for which it is necessary ...
M.B. Dzhus+3 more
doaj +1 more source
Multiscreen serum analysis of highly sensitized renal dialysis patients for antibodies toward public and private class I HLA determinants: Implications for computer-predicted acceptable and unacceptable donor mismatches in kidney transplantation [PDF]
A multiscreen serum analysis program has been developed that permits a determination of antibody specificity for the vast majority of highly sensitized patients awaiting transplantation.
Banner, BF+6 more
core +1 more source
CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core +2 more sources
HLA B27 y las espondilartropatías seronegativas
Se realizó el tipaje serológico para el antígeno HLA B27 a 19 pacientes con espondilartropatías seronegativas para conocer su relación y, de ellos, 6 resultaron positivos; 94 individuos sanos conformaron el grupo control y en 4 se encontró el antígeno ...
Modesto González Cortiñas+3 more
doaj
A Review of the Molecular and Genetic Foundations of Ankylosing Spondylitis [PDF]
Ankylosing Spondylitis (AS) is an autoimmune disease that occurs in an adult-onset or juvenile-onset form. The symptoms, severity, and prevalence of this disease vary according to sex, age, and race.
Dowlearn, Emily
core
Role of subclinical gut inflammation in the pathogenesis of spondyloarthritis [PDF]
Subclinical gut inflammation occurring in patients affected by spondyloarthritis (SpA) is correlated with the severity of spine inflammation. Several evidences indicate that dysbiosis occurs in SpA, and that may modulate intestinal permeability and ...
Ciccia F.+3 more
core +1 more source
Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease [PDF]
We examined how HLA types A1-B8-DR3 and B27 were related to progression of clinical disease and rate of loss of CD4 lymphocytes in the Edinburgh City Hospital cohort of HIV-positive patients, mainly injection drug users.
Brettle, R.P.+9 more
core
Background The Assessment of SpondyloArthritis international Society (ASAS) defines a positive family history (PFH) of spondyloarthritis (SpA) as the presence of ankylosing spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA ...
Miranda van Lunteren+6 more
doaj +1 more source