Results 121 to 130 of about 144,091 (315)

Glaucoma primario de ángulo abierto y HLA B35 Primary open-angle glaucoma and HLA B35

Revista Cubana de Hematología, Inmunología y Hemoterapia, 1999
Se determinó la frecuencia de 29 antígenos HLA de los loci A y B en 20 pacientes con glaucoma primario de ángulo abierto diagnósticados en el Servicio de Oftalmología del Hospital General Docente «Enrique Cabrera».
Luz M Morera Barrios, Rosa Ricardo Lorenzo, Gloria Hernández, Zoila C Martínez Legón, Ana M Guerreiro Hernández, Mayra Agüero Martínez   +5 more
doaj  

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Characterisation of HLA-specific antibodies [PDF]

A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the ...
Lowe, David Philip
core  

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Contributions of vitamin D response elements and HLA promoters to multiple sclerosis risk

, 2012
Objective: The identification of a vitamin D-responsive (VDRE) motif within the HLA-DRB1*15:01 promoter region provides an attractive explanation for the combined effects of HLA-DR inheritance and vitamin D exposure on multiple sclerosis (MS) risk.
Qiu, W., Nolan, D., Kermode, A., Tschochner, M., Mastaglia, F., Christiansen, F.T., Witt, C., Castley, A., James, I., Sayer, D., Carroll, W.   +10 more
core  

Animal models in molecular biology research: Challenges, ethical imperatives, and the path to human‐relevant translation

Animal Models and Experimental Medicine, EarlyView.
The graphical abstract shows how molecular biology research has shifted from using traditional animal models toward using methods that are more relevant to humans. It points out the main problems, differences between species, difficulty in reproducing results, moral issues, and lack of infrastructure that make translational accuracy harder to achieve ...
Md. Shajid Hossain Rafi, Md. Taslim Sarker, Ferdous‐Ul‐Haque Joy, Shahriar Mohd Shams, Tahmina Foyez, Md. Abdul Mazid, Syed Masudur Rahman Dewan   +6 more
wiley   +1 more source

Estudio preliminar de la frecuencia fenotípica y génica de los antígenos HLA en la enfermedad de Voght-Koyanagi-Harada Preliminary study of the phenotypical and genic frequency of HLA antigens in Voght-Koyanagi-Harada’s disease

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2001
Se determinó la frecuencia de 67 antígenos HLA de clase I (loci A, B y C) y 18 de clase II en 15 pacientes portadores del síndrome de Voght-Koyanagi-Harada, diagnosticados en los servicios de Oftalmología del Hospital General “Enrique Cabrera”
Luz M Morera Barrios, Tomás Verdura González, Rosa Ricardo Lorenzo, Daysy Vilches, Zoila C Martínez Legón, Ana M Guerreiro Hernández   +5 more
doaj  

A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.

, 2007
A cDNA vaccine (pVax1/pet-neu) was designed to encode 12 different Her-2/ErbB-2-derived, HLA-A*0201-restricted dominant and high-affinity heteroclitic cryptic epitopes.
Lemonnier, François A, A. M. Jackson, Alimandi, Maurizio, Jordan Marrocco, Cencioni, Giulia, S. Chouaib, Stephanie Graf-Dubois, Graf-Dubois, S, Chouaib, S, A. Scardino, Hüseyin Firat, Graf-Dubois, Stephanie, Steven G. Smith, K. Kosmatopoulos, Kosmatopoulos, K., Smith, SG, Antonio Scardino, Roberto Bei, Giulia Cencioni, S. G. Smith, G. Cencioni, P. Correale, François A. Lemonnier, Kosmatopoulos, Kostas, Faure, Olivier, Firat, Hüseyin, Olivier Faure, Firat, H, Lemonnier, FA, Jackson, AM, Kostas Kosmatopoulos, Chouaib, Salem, Correale, P, Andrew Michael Jackson, Cusi, MG, Maria Grazia Cusi, Alimandi, M, Correale, Pierpaolo, Bei, Roberto, M. G. Cusi, Marrocco, Jordan, S. Graf Dubois, F. A. Lemonnier, Smith, Steven G, Scardino, A, Cencioni, G, Pierpaolo Correale, Graf Dubois, S, Salem Chouaib, Faure, O, Marrocco, J, Kosmatopoulos, K, Scardino, Antonio, Cusi, Maria Grazia, J. Marrocco, Bei, R, R. Bei, Maurizio Alimandi, H. Firat, O. Faure, Jackson, Andrew Michael   +60 more
core   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source