Results 1 to 10 of about 3,332 (70)

High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome

Frontiers in Medicine, 2022
The aims of this study were to investigate the activation of T lymphocytes in peripheral blood from children with Hodgkin's lymphoma (HL) and explore their roles for prognosis in HL.
Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu, Qiang Shu   +9 more
doaj   +1 more source

A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

Frontiers in Oncology, 2021
The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the ...
Laura Gadeyne, Yannick Van Herck, Giorgia Milli, Zeynep Kalender Atak, Maddalena Maria Bolognesi, Jasper Wouters, Lukas Marcelis, Angeliki Minia, Vaia Pliaka, Jan Roznac, Jan Roznac, Leonidas G. Alexopoulos, Leonidas G. Alexopoulos, Giorgio Cattoretti, Oliver Bechter, Joost Van Den Oord, Frederik De Smet, Asier Antoranz, Francesca Maria Bosisio   +18 more
doaj   +1 more source

Antigen presenting subset of СD66b⁺CD16⁺CD33⁺HLA-DR⁺ neutrophilic granulocytes in acute osteomyelitis in children: Immunomodulating effects of immunotropic hexapeptide in an in vitro experimental system

Медицинская иммунология, 2023
Inclusion of neutrophilic granulocytes (NG) in inflammation depends on the expression of receptors providing the functions of NG. Acute osteomyelitis (AOM) occupies a central place among purulentinflammatory diseases in children.
I. V. Nesterova, G. A. Chudilova, Yu. V. Teterin, E. A. Chicherev, V. N. Chapurina, M. N. Mitropanova   +5 more
doaj   +1 more source

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

Frontiers in Microbiology, 2019
To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR).
Eunok Lee, Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer, Sarah Palmer   +14 more
doaj   +1 more source

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells

Stem Cells International, 2021
Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time.
Yoo-Wook Kwon, Hyo-Suk Ahn, Jin-Woo Lee, Han-Mo Yang, Hyun-Jai Cho, Seok Joong Kim, Shin-Hyae Lee, Heung-Mo Yang, Hyun-Duk Jang, Sung Joo Kim, Hyo-Soo Kim   +10 more
doaj   +1 more source

Persistent High Percentage of HLA-DR+CD38high CD8+ T Cells Associated With Immune Disorder and Disease Severity of COVID-19

Frontiers in Immunology, 2021
BackgroundThe global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases.
Juan Du, Lirong Wei, Guoli Li, Mingxi Hua, Yao Sun, Di Wang, Kai Han, Yonghong Yan, Chuan Song, Rui Song, Henghui Zhang, Junyan Han, Jingyuan Liu, Yaxian Kong   +13 more
doaj   +1 more source

Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis

Chinese Neurosurgical Journal, 2017
Background Human leukocyte antigen (HLA)-DR is a classical major histocompatibility complex (MHC) class II molecule encoded by five genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5.
Xing Fan, Jingshan Liang, Zhifeng Wu, Xia Shan, Hui Qiao, Tao Jiang   +5 more
doaj   +1 more source

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus. [PDF]

PLoS ONE, 2016
The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their ...
Kwangwoo Kim, So-Young Bang, Dae Hyun Yoo, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Young Mo Kang, Chang-Hee Suh, Seung-Cheol Shim, Shin-Seok Lee, Jisoo Lee, Won Tae Chung, Seong-Kyu Kim, Jung-Yoon Choe, Swapan K Nath, Hye-Soon Lee, Sang-Cheol Bae   +18 more
doaj   +1 more source

HLA-DR-Positive NK Cells Expand in Response to Mycobacterium Tuberculosis Antigens and Mediate Mycobacteria-Induced T Cell Activation

Frontiers in Immunology, 2021
NK cells play an important role in the control of tuberculosis infection: they are not only able to kill the infected cells, but also control the activity of macrophages and development of the adaptive immune response.
Sofya A. Kust, Maria A. Streltsova, Alexander V. Panteleev, Natalya L. Karpina, Irina V. Lyadova, Irina V. Lyadova, Alexander M. Sapozhnikov, Elena I. Kovalenko   +7 more
doaj   +1 more source

Expression of HLA-DR in pheripheral nerve of amyotrophic lateral sclerosis

Arquivos de Neuro-Psiquiatria, 1994
To investigate the possibility of local antigen presentation within the peripheral nerve in amyotrophic lateral sclerosis (ALS), cryostat sections of 83 peripheral nerve biopsies were stained for the demonstration of HLA-DR using a monoclonal antibody ...
A.S.B. Oliveira, E. Isozaki, D. Younger, A.A. Gabbai, A.P. Hays   +4 more
doaj   +1 more source