Results 1 to 10 of about 173,850 (199)

Expression of HLA-DR in pheripheral nerve of amyotrophic lateral sclerosis [PDF]

Arquivos de Neuro-Psiquiatria, 1994
To investigate the possibility of local antigen presentation within the peripheral nerve in amyotrophic lateral sclerosis (ALS), cryostat sections of 83 peripheral nerve biopsies were stained for the demonstration of HLA-DR using a monoclonal antibody ...
A.S.B. Oliveira, E. Isozaki, D. Younger, A.A. Gabbai, A.P. Hays   +4 more
doaj   +2 more sources

HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy [PDF]

Frontiers in Immunology, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Diana P. Saraiva, António Jacinto, Paula Borralho, Paula Borralho, Sofia Braga, Sofia Braga, Sofia Braga, M. Guadalupe Cabral   +7 more
doaj   +4 more sources

Impaired graft survival in kidney transplants from expanded criteria donors with HLA-DR mismatch [PDF]

Frontiers in Transplantation
Human leukocyte antigen (HLA)-DR mismatches are known to increase the risk of graft rejection following kidney transplantation (KT). Especially in KT using grafts of lower quality from expanded criteria donors (ECD), the immune response plays a critical ...
Uwe Scheuermann, Philipp Rhode, Claudia Lehmann, Jan Kowald, Sophie Seiffer, Fabian Haak, Daniel Seehofer, Sebastian Murad Rabe, Hans-Michael Tautenhahn   +8 more
doaj   +2 more sources

Challenges of monocyte HLA-DR targeted immunomodulation in sepsis—a prospective observational cohort study [PDF]

Frontiers in Immunology
IntroductionReduced monocyte HLA-DR expression, a hallmark of immunosuppression in sepsis, is associated with infectious complications and mortality. Therapeutic strategies, including IFN-γ, have been used to restore monocyte HLA-DR and immune function ...
Timothy Arthur Chandos Snow, Antoine Villa, Antonio Cesar, Francis Ryckaert, Naveed Saleem, Deborah Smyth, Holly Pan, Julia Flint, David Brealey, David Brealey, Mervyn Singer, Derek W. Gilroy, Nishkantha Arulkumaran, the University College London Hospitals Critical Care Research Team   +13 more
doaj   +2 more sources

Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants [PDF]

Frontiers in Nephrology
BackgroundThis study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of ...
Pooja Budhiraja, Jesse D. Schold, Jesse D. Schold, Rocio Lopez, Rocio Lopez, Susana Arrigain, Susana Arrigain, Bruce Kaplan, Bruce Kaplan   +8 more
doaj   +2 more sources

HLA-DR expression in cytotoxic T lymphocytes: a key to boost the therapeutic potential of T cell-based strategies for breast cancer [PDF]

Frontiers in Immunology
T cell-based therapies, involving ex vivo expansion of patients’ T lymphocytes, hold significant promise for chemotherapy resistant cases of breast cancer (BC), although their effectiveness remains challenging.
Rute Salvador, Bruna Filipa Correia, Daniela Grosa, Telma Martins, Telma Martins, Suelen Cristina Soares Baal, Diana Pereira Saraiva, Sofia Cristóvão-Ferreira, Isabel Lopes Pereira, Cátia Rebelo de Almeida, Rita Fior, Antonio Jacinto, Carolina Mathias, Sofia Braga, Sofia Braga, Sofia Braga, M. Guadalupe Cabral   +16 more
doaj   +2 more sources

Prediction of Potential Drugs Targeting Acute Pancreatitis Based on the HLA-DR-Related Gene-Monocyte Infiltration Regulatory Network [PDF]

Biomedical Engineering and Computational Biology
Background: Acute pancreatitis (AP) is a common disease of acute abdominal pain, the incidence of which is increasing annually, but its pathogenesis remains incompletely understood.
Wei Xu, Lan Hu, Shengyi Shi, Jie Gao, Jing Ye, Yiming Lu   +5 more
doaj   +2 more sources

Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis [PDF]

Clinical Immunology Communications
This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were
Amer Khojah, Madeline Schutt, Gabrielle Morgan, Ameera Bukhari, Nicolas Bensen, Aaruni Khanolkar, Lauren M. Pachman   +6 more
doaj   +2 more sources

Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation [PDF]

Frontiers in Immunology
IntroductionRheumatoid arthritis (RA) is a systemic autoimmune disease that leads to inflammation of synovial joints and other organs. Many RA patients “share” a common peptide sequence within the HLA-DR (MHC II) molecule expressed on antigen-presenting ...
Christian Geier, Haani Qudsi, Estelle Khairallah, Jihad Ben Gabr, Robert Winchester, Andras Perl   +5 more
doaj   +2 more sources

High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome

Frontiers in Medicine, 2022
The aims of this study were to investigate the activation of T lymphocytes in peripheral blood from children with Hodgkin's lymphoma (HL) and explore their roles for prognosis in HL.
Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu, Qiang Shu   +9 more
doaj   +1 more source