Results 41 to 50 of about 173,850 (199)

The causal relationship between immune cells and diabetic retinopathy: a Mendelian randomization study

Frontiers in Immunology
PurposeThis article explored the causal relationship between immune cells and diabetic retinopathy (DR) using single nucleotide polymorphisms (SNPs) as an instrumental variable and Mendelian randomization (MR).MethodsStatistical data were collected from ...
Yunyan Ye, Lei Dai, Hong Gu, Lan Yang, Zhangxing Xu, Zhiguo Li   +5 more
doaj   +1 more source

Circulating Placental Vesicles Carry HLA-DR in Pre-Eclampsia: A New Potential Marker of the Syndrome

Frontiers in Immunology, 2021
BackgroundPre-eclampsia (PE) is a common disorder of pregnancy that usually presents with hypertension and proteinuria. The clinical presentation arises from soluble factors released into the maternal circulation from the placenta owing to the stress of ...
Chiara Tersigni, Donatella Lucchetti, Rita Franco, Filomena Colella, Caterina Neri, Laura Crispino, Alessandro Sgambato, Antonio Lanzone, Antonio Lanzone, Giovanni Scambia, Giovanni Scambia, Manu Vatish, Nicoletta Di Simone, Nicoletta Di Simone   +13 more
doaj   +1 more source

HLA-DR Expression and Soluble HLA-DR Levels in Septic Patients After Trauma

Annals of Surgery, 1999
To determine if cellular and soluble HLA-DR molecules may be relevant in severely injured patients for the development of gram-positive or gram-negative sepsis.HLA-DR molecules play a central role in the specific immune response to infection. The reduced HLA-DR expression on monocytes is considered to correlate with infectious complications and the ...
M, Ditschkowski, E, Kreuzfelder, V, Rebmann, S, Ferencik, M, Majetschak, E N, Schmid, U, Obertacke, H, Hirche, U F, Schade, H, Grosse-Wilde   +9 more
openaire   +3 more sources

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA

Journal of Immunology Research, 2017
The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the ...
Vadim Jucaud
doaj   +1 more source

Comparative profiling of HLA-DR and HLA-DQ associated factor VIII peptides presented by monocyte-derived dendritic cells

Haematologica, 2018
The development of anti-factor VIII antibodies is a major complication of the treatment of patients with hemophilia A. Generation of high affinity anti-factor VIII antibodies is dependent on help provided by CD4+ T cells that recognize factor VIII ...
Ivan Peyron, Robin B. Hartholt, Laura Pedró-Cos, Floris van Alphen, Anja ten Brinke, Neubury Lardy, Alexander B. Meijer, Jan Voorberg   +7 more
doaj   +1 more source

Interferon‐γ‐induced HLA Class II expression on endothelial cells is decreased by inhibition of mTOR and HMG‐CoA reductase

FEBS Open Bio, 2020
In organ transplantation, donor‐specific HLA antibody (DSA) is considered a major cause of graft rejection. Because DSA targets primarily donor‐specific human leukocyte antigen (HLA) expressed on graft endothelial cells, the prevention of its expression ...
Akihiro Maenaka, Iwasaki Kenta, Akinobu Ota, Yuko Miwa, Wataru Ohashi, Kosei Horimi, Yutaka Matsuoka, Masafumi Ohnishi, Kazuharu Uchida, Takaaki Kobayashi   +9 more
doaj   +1 more source

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study [PDF]

, 2016
There is an increasing interest for monitoring circulating myeloid-derived suppressor cells (MDSCs) in cancer patients, but there are also divergences in their phenotypic definition.
Brandau, Sven, Britten, Cedrik M, Bronte, Vincenzo, Damuzzo, Vera, Gouttefangeas, C\ue9cile, Mandruzzato, Susanna, Maurer, Dominik, Ottensmeier, Christian, van der Burg, Sjoerd H, Walter, Steffen, Welters, Marij J. P   +10 more
core   +2 more sources

Molecular analysis of thymopentin binding to HLA-DR molecules.

PLoS ONE, 2007
Thymopentin (TP5) triggers an immune response by contacting with T cells; however the molecular basis of how TP5 achieves this process remains incompletely understood.
Zuojia Liu, Xiliang Zheng, Jin Wang, Erkang Wang   +3 more
doaj   +1 more source

HLA-DR and -DQ antibodies in the sera of South India Parous women [PDF]

, 1992
HLA-A, -B positive sera of south Indian parous women were screened for the presence of HLA-DR and -DQ antibodies. The sera were absorbed with pooled platelets in a micro-method and screened against HLA-DR and -DQ typed B-lymphocytes panel.
Chandrasekaran, P, Damodaran, C, Narayanan, P R, Prabhakar, R, Selvaraj, P, Subramanian, V S   +5 more
core  

HDAC inhibition potentiates immunotherapy in triple negative breast cancer. [PDF]

, 2017
Triple-negative breast cancer (TNBC) represents a more aggressive and difficult subtype of breast cancer where responses to chemotherapy occur, but toxicity is significant and resistance often follows. Immunotherapy has shown promising results in various
Ali, Niwa, Budillon, Alfredo, Krings, Gregor, Munster, Pamela N, Park, Jeenah, Pawlowska, Nela, Rosenblum, Michael D, Terranova-Barberio, Manuela, Thomas, Scott   +8 more
core   +1 more source