Results 41 to 50 of about 2,861,094 (164)

HLA-DR Expression and Soluble HLA-DR Levels in Septic Patients After Trauma

Annals of Surgery, 1999
To determine if cellular and soluble HLA-DR molecules may be relevant in severely injured patients for the development of gram-positive or gram-negative sepsis.HLA-DR molecules play a central role in the specific immune response to infection. The reduced HLA-DR expression on monocytes is considered to correlate with infectious complications and the ...
M, Ditschkowski, E, Kreuzfelder, V, Rebmann, S, Ferencik, M, Majetschak, E N, Schmid, U, Obertacke, H, Hirche, U F, Schade, H, Grosse-Wilde   +9 more
openaire   +3 more sources

Expression pattern of HLA-G and HLA-DR molecules on lymphocytes of women and their children with septal congenital heart defects

Медицинская иммунология
The aim of our study was to evaluate the features of HLA-G and HLA-DR expression on lymphocytes of women and their children with congenital heart defects (CHD) under the influence of allogeneic and autologous blood sera.38 women and their children with ...
A. V. Shabaldin, A. V. Sinitskaya, S. A. Shmulevich, E. O. Grishacheva   +3 more
doaj   +1 more source

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Haematologica, 2018
Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 ...
Johana Hrdinová, Fabian C. Verbij, Paul H.P. Kaijen, Robin B. Hartholt, Floris van Alphen, Neubury Lardy, Anja ten Brinke, Karen Vanhoorelbeke, Pooja J. Hindocha, Anne S. De Groot, Alexander B. Meijer, Jan Voorberg, Ivan Peyron   +12 more
doaj   +1 more source

HLA-DR expression on monocytes and plasma levels of IL-6.

, 2018
(A) HLA-DR expression in sepsis. Surface expression of HLA-DR on CD14++-monocytes analyzed in whole blood samples from patients with sepsis and healthy controls using flow cytometry ...
Christoph Arens (5746865), Christoph Lichtenstern (707424), Sebastian Weiterer (535133), Marek Bartkuhn (31889), Markus Alexander Weigand (5421071), Benedikt Hermann Siegler (5421062), Florian Uhle (250479)   +6 more
core   +1 more source

Comparing Effects of BK Virus Agnoprotein and Herpes Simplex-1 ICP47 on MHC-I and MHC-II Expression

Clinical and Developmental Immunology, 2013
Background. Among human polyomaviruses, only BK virus (BKV) and JC virus (JCV) encode an agnoprotein upstream of VP1 on the viral late transcript. BKV agnoprotein is abundantly expressed late in the viral life cycle, but specific cellular and humoral ...
Michela Cioni, Christian Mittelholzer, Marion Wernli, Hans H. Hirsch   +3 more
doaj   +1 more source

Real-Time Distributed Aircraft Simulation through HLA [PDF]

, 2012
This paper presents some ongoing researches carried out in the context of the PRISE (Research Platform for Embedded Systems Engineering) Project. This platform has been designed to evaluate and validate new embedded system concepts and techniques through
Leconte, Régine, Gervais, Clément, Clement Gervais, Regine Leconte, Pierre Siron, Saussié, David, Chaudron, Jean-Baptiste, Siron, Pierre, David Saussie, Jean-Baptise Chaudron, Chaudron, Jean-Baptise   +10 more
core   +1 more source

HLA-DR and the Development of Rheumatoid Arthritis

Autoimmunity, 1997
Susceptibility to develop Rheumatoid arthritis (RA) maps to a highly conserved amino acid motif ("the shared epitope") expressed in the third hypervariable region of different HLA-DRB1 alleles. This motif, namely QKRAA, QRRAA or RRRAA helps the development of RA by an unknown mechanism.
Auger, Isabelle, Roudier, Jean
openaire   +2 more sources

Prediction of Potential Drugs Targeting Acute Pancreatitis Based on the HLA-DR-Related Gene-Monocyte Infiltration Regulatory Network

Biomedical Engineering and Computational Biology
Background: Acute pancreatitis (AP) is a common disease of acute abdominal pain, the incidence of which is increasing annually, but its pathogenesis remains incompletely understood.
Wei Xu, Lan Hu, Shengyi Shi, Jie Gao, Jing Ye, Yiming Lu   +5 more
doaj   +1 more source

Mediating Role of Blood Metabolites in the Relationship Between Immune Cell Traits and Heart Failure: A Mendelian Randomization and Mediation Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Observational studies have shown a significant association between immune cells and heart failure (HF). Nevertheless, the precise biological mechanisms underlying this association remain unclear.
Yi Liu, Chenfu Shen, Yu Cao
doaj   +1 more source

HLA-DR/DQ eplet mismatch predicts de novo donor-specific antibody development in multi-ethnic Southeast Asian kidney transplant recipients on different immunosuppression regimens

Frontiers in Genetics
Eplet mismatch has been recognized as a more precise strategy for determining HLA compatibility by analyzing donor-recipient HLA differences at the molecular level.
Emmett Tsz Yeung Wong, Emmett Tsz Yeung Wong, Emmett Tsz Yeung Wong, Denise Pochinco, Anantharaman Vathsala, Anantharaman Vathsala, Wee Kun Koh, Amy Lim, Hersharan Kaur Sran, Hersharan Kaur Sran, Matthew Ross D’Costa, Zi Yun Chang, Peter W. Nickerson, Peter W. Nickerson, Peter W. Nickerson, Chris Wiebe, Chris Wiebe, Chris Wiebe   +17 more
doaj   +1 more source