Results 61 to 70 of about 2,861,094 (164)

HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus [PDF]

, 2022
Background: More than 40 genes influence the progression of type 1 diabetes mellitus (T1DM), including human leukocyte antigen (HLA) alleles. Different HLA genotype patterns result in diverse rates of T1DM development.
Nur Rochmah, -, Soetjipto, -, Yuni Hisbiyah, -, Anang Endaryanto, -, Muhammad Faizi, -   +4 more
core   +2 more sources

HLA-DR production and localisation in cultured healthy control monocytes.

, 2018
(A) Surface mHLA-DR expression (geometric mean fluorescent intensity (MFI)) of healthy donor PBMCs cultured in serum obtained from the pre- or post-operative (24 hour) period; (B-C) HLA-DR α-chain and Cathepsin S (CTSS) mRNA levels from monocytes sorted (
Mark E. Vivian (5746448), Bagrat Lalabekyan (5746451), Hew D. T. Torrance (5746442), Tom E. F. Abbott (5746454), Michael J. O’Dwyer (5746463), Charles J. Hinds (5746460), E. Rebecca Longbottom (5746445), Rupert M. Pearse (595329), Gareth L. Ackland (5746457)   +8 more
core   +1 more source

Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study [PDF]

, 2009
Background: Mounting evidence indicates that HLA-mediated HIV evolution follows highly stereotypic pathways that result in HLA-associated footprints in HIV at the population level.
Santiago Avila-Rios, Avila-Rios, S., Brumme, Z.L., Espinosa Enrique, Carlson, J.M., Valenzuela-Ponce Humberto, Carlson Jonathan M, John Mina, Ormsby Christopher E, David Heckerman, Heckerman, D., Juan Blanco-Heredia, Blanco-Heredia Juan, Mallal Simon, Brumme Zabrina L, Daniela Garrido-Rodriguez, Espinosa, E., Enrique Espinosa, Reyes-Teran Gustavo, Garrido-Rodriguez, D., Ormsby, C.E., Valenzuela-Ponce, H., Garcia-Morales Claudia, Zabrina L Brumme, John, M., Heckerman David, Simon Mallal, Gustavo Reyes-Teran, Claudia Garcia-Morales, Christopher E Ormsby, Humberto Valenzuela-Ponce, Garrido-Rodriguez Daniela, Avila-Rios Santiago, Mina John, Garcia-Morales, C., Jonathan M Carlson, Reyes-Teran, G., Blanco-Heredia, J., Mallal, S.   +38 more
core   +1 more source

HLA-DR regulation and the influence of GM-CSF on transcription, surface expression and shedding

International Journal of Medical Sciences, 2004
Low surface HLA-DR expression is a feature in sepsis. However, the mechanisms that regulate HLA-DR expression have not been elucidated. The current study investigates regulation of HLA-DR gene transcription, post transcriptional events and shedding of ...
doaj  

Identification of a novel HLA-C*08 allele, HLA-C*08:01:20

, 2017
HLA-C*08:01:20 differs from C*08:01:01 by a single nucleotide substitution at position 93 of exon 2.SCI(E)EDITORIAL MATERIAL3178 ...
D. Li, Yu, Y., B. Xi, M.-R. Huo, Xi, B., Li, D., Huo, M.R., Y. Yu   +7 more
core   +1 more source

HLA-DR expression in cytotoxic T lymphocytes: a key to boost the therapeutic potential of T cell-based strategies for breast cancer

Frontiers in Immunology
T cell-based therapies, involving ex vivo expansion of patients’ T lymphocytes, hold significant promise for chemotherapy resistant cases of breast cancer (BC), although their effectiveness remains challenging.
Rute Salvador, Bruna Filipa Correia, Daniela Grosa, Telma Martins, Telma Martins, Suelen Cristina Soares Baal, Diana Pereira Saraiva, Sofia Cristóvão-Ferreira, Isabel Lopes Pereira, Cátia Rebelo de Almeida, Rita Fior, Antonio Jacinto, Carolina Mathias, Sofia Braga, Sofia Braga, Sofia Braga, M. Guadalupe Cabral   +16 more
doaj   +1 more source

Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history [PDF]

, 2006
The major histocompatibility complex (MHC) is recognised as one of the most important genetic regions in relation to common human disease. Advancement in identification of MHC genes that confer susceptibility to disease requires greater knowledge of ...
John Trowsdale, Wilming, LG, Roberts Anne N, Coggill, P, Laurens G Wilming, Sarah Sims, Trowsdale, J, Atrazhev Alexey M, Palmer, S, Beck Stephan, Todd John A, Jane Rogers, Sawcer, S, Coggill Penny, Ashurst Jennifer L, Trowsdale John, Almeida Jeff, Alexey M Atrazhev, Elliott John F, Beck, S, Sophie Palmer, Hurles Matthew E, Traherne James A, Roberts, AN, Miretti, M, Stewart, CA, de Jong, PJ, Pieter J de Jong, Stephen Sawcer, Hurles, ME, James A Traherne, C Andrew Stewart, de Jong Pieter J., Matthew E Hurles, Horton, R, Penny Coggill, Jennifer L Ashurst, Sims, S, Horton Roger, Stewart C. Andrew, Almeida, J, Ashurst, JL, Carrington Mary, Elliott, JF, C. Andrew Stewart, Stephan Beck, Rogers Jane, Palmer Sophie, Pieter J. de Jong, Carrington, M, Rogers, J, Atrazhev, AM, Roger Horton, Sawcer Stephen, Traherne, JA, Jeff Almeida, Sims Sarah, John A Todd, Marcos M Miretti, Anne N Roberts, Wilming Laurens G, Todd, JA, Mary Carrington, Miretti Marcos M, John F Elliott   +64 more
core   +1 more source

Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target

Frontiers in Endocrinology
ObjectiveIncreasing evidence has suggested that immune cells are known to play a pivotal role in the progression of diabetic nephropathy (DN). However, the specific causal role of monocyte surface markers, particularly human leukocyte antigen-DR (HLA-DR),
Yue Wang, Shaojie Fu, Sensen Su, Zhonggao Xu   +3 more
doaj   +1 more source

The impact of HLA-DR on the development and healing of cardiac allograft rejection

, 2007
Titelblatt und Inhaltsverzeichnis Einleitung Ziel der Arbeit und Aufgabenstellung Literaturübersicht Grundlagen der Transplantationsmedizin Material Methoden Ergebnisse Diskussion Zusammenfassung Literaturverzeichnis Anlage ...
Sezgin, Yasar
core   +1 more source

Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]

, 1992
The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Kellermann, Josef, Johnson, Judith P., Matthias Ulbrecht, Ulbrecht, Matthias, Josef Kellermann, Judith P. Johnson, Weiss, Elisabeth H., Elisabeth H. Weiss   +7 more
core   +1 more source