Results 131 to 140 of about 1,839,216 (336)
Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease
Arthritis &Rheumatology, EarlyView.Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman +2 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Giant cell arteritis (GCA) is a large‐vessel vasculitis, potentially causing complications such as blindness and strokes. This study aims to gain insights into the pathogenesis of GCA by identifying specific DNA methylation signatures in the arterial tissue of patients with this vasculitis. Methods DNA methylation profiling was analyzed in 79
Gonzalo Borrego‐Yaniz +18 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Fecal microbiota transplantation (FMT) holds promises as a beneficial supplement to methotrexate in patients with psoriatic arthritis (PsA). We therefore investigated how gut bacterial signatures in patients and donor strain engraftment were associated with long‐term response to FMT.
Panpan Qin +7 more
wiley +1 more source
A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis
Arthritis &Rheumatology, Accepted Article.Background Individuals with serum elevations of anti‐cyclic citrullinated peptide (anti‐CCP) antibodies are at increased risk for future rheumatoid arthritis (RA). No pharmacologic interventions have been approved for the prevention of RA in such ‘at‐risk’ individuals. However, hydroxychloroquine (HCQ) is used without supporting clinical trial evidence.
Kevin D. Deane +33 more
wiley +1 more source
Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]
, 2008 Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core
Arthritis &Rheumatology, EarlyView.Objective Cellular mechanisms driving transition from psoriasis to psoriatic arthritis have remained largely elusive. Thus, we investigated changes within the peripheral blood T cell compartment associated with the transition phase. Methods In an observational study, 116 patients were examined and categorized into subgroups including psoriasis with at ...
Hanna Graßhoff +19 more
wiley +1 more source
"Induction of Thymic HLA-DR signaling with Alpha-smooth muscle Actin expression during the second and third trimesters of gestation " [PDF]
Acta Medica Iranica, 2003 Less than 5% of prenatal thymoctes express HLA-DR before week 12 of gestation. However, the number of HLA-DR- positive cells increases during the late second and third trimesters of development. To determine the role of alpha-smooth muscle actin in fetal
Tamiolakis D +5 more
doaj
Origin of lymph node-derived lymphocytes in human hepatic allografts [PDF]
, 1989 Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node.
Chen, K +7 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Anticitrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) can be promiscuous, with cross‐reactive binding to many antigens containing short motifs, or private with little cross‐reactivity. Also, ACPA reactivity patterns differ among patients with RA, including for motif‐containing epitopes in important self‐antigens like ...
S. Janna Bashar +4 more
wiley +1 more source
Oral lichen planus and HLA DR.
Collegium antropologicum, 1998 Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disease, predominantly seen in middle-aged female patients. Histopathologically, OLP includes parakeratosis with T-lymphocyte subepithelial infiltration. In etiology of OLP, chronically liver and biliary diseases, stress-induced hypertension, inheritance and most commonly carbohydrate ...
Ognjenović, Marina +4 more
openaire +2 more sources