Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini +4 more
wiley +1 more source
Comparative Performance of Flow Cytometry and ELISA for Detecting Ki-67 and HLA-DR in Whole Blood: Implications for Tuberculosis Diagnosis and Treatment Monitoring. [PDF]
Dangi JS +5 more
europepmc +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Methyl-CpG-binding domain protein 2 epigenetically represses monocyte HLA-DR expression and promotes immune paralysis in HBV-related acute-on-chronic liver failure. [PDF]
Liu X +8 more
europepmc +1 more source
Risk of invasive cervical cancer associated with polymorphic HLA DR/DQ haplotypes [PDF]
Mehran Ghaderi +7 more
openalex +1 more source
ABSTRACT Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services.
Ganna Shestakova +2 more
wiley +1 more source
Increased HLA-DR Expression on M2a Monocytes and Helper T Cells in Patients with COPD and Asthma-COPD Overlap Contributes to Disease Severity via Apoptosis and ROS. [PDF]
Chen YC +8 more
europepmc +1 more source
Basophil Activation Test for the In Vitro Diagnosis of Tocilizumab Hypersensitivity
Clinical &Experimental Allergy, EarlyView.
Ana Koren +3 more
wiley +1 more source
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala +14 more
wiley +1 more source

