Results 271 to 280 of about 114,761 (352)

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

CD45 on CD33br HLA-DR+ immune cells promote cholecystitis via glycine-mediated pathways: A Mendelian randomization study. [PDF]

Medicine (Baltimore)
Zeng X, Song R, Zhang Z, Yao J, Liao H, Wang C, Xu Z, Yang H.   +7 more
europepmc   +1 more source

Identifying Therapeutic Targets for Bronchial Asthma: Systematic Druggable Genome‐Wide Mendelian Randomization

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background The treatment and prevention of bronchial asthma continue to present significant challenges. Mendelian randomization (MR) has been extensively employed to identify novel therapeutic targets. Consequently, we conducted a systematic MR analysis across the druggable genome to identify potential therapeutic targets for asthma.
Haijiao Wang, Peng Zhang, Hongpeng Yu, Li Shi, Tan Wang   +4 more
wiley   +1 more source

The exploration of immunological landscape and drug targets in chronic rhinosinusitis with nasal polyps. [PDF]

World Allergy Organ J
Zhang R, Fu P, Tian H.
europepmc   +1 more source

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions

Interdisciplinary Medicine, Volume 4, Issue 1, January 2026.
This review explores the role of metabolic reprogramming in inflammatory bowel disease (IBD) by focusing on immune and epithelial cell metabolism, microbial metabolites, and their impact on inflammation. It discusses emerging metabolic therapies and emphasizes the importance of personalized microbiota‐targeted approaches to improve clinical outcomes in
Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu   +6 more
wiley   +1 more source

Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis. [PDF]

J Int Med Res
Huang G, Huang Y, Liao G, Xiao K, Li C, Gu R.   +5 more
europepmc   +1 more source

Angiogenic Potential of Small Extracellular Vesicles Produced by Stimulated Mesenchymal Stromal Cells Under Hypoxic Conditions

Journal of Extracellular Biology, Volume 5, Issue 1, January 2026.
ABSTRACT Regenerative vascular medicine research has positioned mesenchymal stromal cells (MSCs) as a leading candidate to treat ischemic diseases. Recent studies have highlighted the emerging role of small extracellular vesicles (sEVs) produced by MSCs in their own potential.
Nada Serhal, Bertrand Brassart, Lise Nannan, Sandra Audonnet, Christine Terryn, Gaël Poitevin, Pascale Cornillet‐Lefebvre, Florine Dubuisson, Hélène Peyret, Philippe Nguyen, Claire Tournois   +10 more
wiley   +1 more source

Monocyte human leukocyte antigen-DR-mediated diabetic nephropathy progression is a promising therapeutic target. [PDF]

Front Endocrinol (Lausanne)
Wang Y, Fu S, Su S, Xu Z.
europepmc   +1 more source

Longitudinal Monitoring of Systemic Cytokines After Mild Zika Virus Infection Revealed an Association Between Th17 Polarization and Clinical and Serological Outcomes

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
ABSTRACT Zika virus (ZIKV) is a neurotropic virus that can cause a variety of neurological manifestations, ranging from mild forms to severe disorders like Guillain–Barré syndrome and congenital Zika syndrome. The pathophysiology of these complications is not fully understood, but they have been linked to host immune responses, particularly a ...
Solène Marquine, Marie Mura, Franck de Laval, Gilda Grard, Cyril Badaut, Sébastien Briolant, Aurélie Trignol   +6 more
wiley   +1 more source

Donor-specific antibodies against HLA-C, HLA-DP and HLA-DQ and their implications in kidney transplantation. [PDF]

World J Transplant
Khalil MAM, Sadagah NM, Hediki I, Tan J, Al-Qurashi SH.   +4 more
europepmc   +1 more source