Results 281 to 290 of about 114,761 (352)

Organ Transplantation: Current Status, Challenges, and Future Prospects

MedComm, Volume 7, Issue 1, January 2026.
Organ transplantation success relies on precise modulation of the alloimmune response across distinct temporal phases of rejection. Hyperacute rejection results from preformed antibodies activating complement and causing thrombosis, while acute rejection involves T cell‐ and antibody‐mediated mechanisms that drive endothelial activation and ...
Xinqiang Li, Ruidong Ding, Jinzhen Cai
wiley   +1 more source

Beyond sequence similarity: ML-powered identification of pHLA off-targets for TCR-mimic antibodies using high throughput binding kinetics. [PDF]

MAbs
Sinclair A, Krämer S, Reinhart C, Stehle J, Schuster S, Herz T, Al Hasani H, Hamde P, Selinger O, Birkenfeld J.   +9 more
europepmc   +1 more source

Regulation and Mechanism of Deleted in Breast Cancer‐1 on Dendritic Cell Function in Systemic Lupus Erythematosus

MedComm, Volume 7, Issue 1, January 2026.
LPS‐stimulated DC activation upregulated DBC1. DBC1‐deficient DC ameliorated murine SLE symptoms. DBC1 deficiency suppressed immune responses in DC. DBC1 deficiency lowered STAT5 expression and subsequent phosphorylation. STAT5 overexpression abolished murine SLE remission primed by DBC1 deficiency.
Ze Xiu Xiao, Rongzhen Liang, Yan Liu, Changyuan Huang, Qiannan Fang, Xiaojiang Hu, Julie Wang, Nancy Olsen, Dehua Wu, Song Guo Zheng   +9 more
wiley   +1 more source

Human Leukocyte Antigen-DR Expression on Monocytes Is a Useful Predictor in a Systemic Inflammation Response-Based Prognostic Model in Advanced Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Szűcs G, Gézsi A, Szentkereszty M, Losonczy G, Barna G, Gálffy G, Bohács A, Tamási L, Müller V, Buzás EI, Komlósi ZI.   +10 more
europepmc   +1 more source

DNA‐Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors

Small Science, Volume 6, Issue 1, January 2026.
Biodegradable poly(beta‐amino ester) nanoparticles can be employed to deliver immunostimulatory genes (4‐1BBL and IL‐12) to reprogram brain tumor cells into antigen‐presenting cells to stimulate an anti‐tumor response, resulting in tumor regression and long‐term survival in GBM and meningioma models.
Joanna Yang, Divyaansh Raj, Hasan Slika, Aanya Shahani, Leonardo Cheng, Manav Jain, Ethan Idnani, Kathryn M. Luly, FNU Ruchika, Caitlin Kraft, Charles Eberhart, Henry Brem, Betty Tyler, Jordan J. Green, Stephany Y. Tzeng   +14 more
wiley   +1 more source

Associations Between Gastroenteropancreatic Neuroendocrine Neoplasms and Inflammatory Factors: Insights From a Two-Sample Mendelian Randomization Analysis. [PDF]

Can J Gastroenterol Hepatol
Guo H, Li Y, Liu B, Liu S.
europepmc   +1 more source

Recent Advances in Orthopedic Tissue Engineering: Bridging Stem Cells and 3D Printing

Small Structures, Volume 7, Issue 1, January 2026.
This review highlights how diverse 3D‐printed scaffold platforms integrate with embryonic, mesenchymal, and induced pluripotent stem cells to guide musculoskeletal regeneration. By linking fabrication strategies with lineage‐specific cues and microenvironmental design principles, the article outlines emerging approaches that enable precise ...
Juyeong J. Lee, Seihyun Park, Inseon Kim, Seunghun S. Lee   +3 more
wiley   +1 more source

Cut or bind? Antigen-specific processing mechanisms define CD4⁺ T cell immunodominant epitopes for SARS-CoV-2 S and N proteins. [PDF]

Genome Med
Álvaro-Benito M, Abualrous ET, Lingel H, Meltendorf S, Holzapfel J, de Diego Valera P, Sticht J, Kuropka B, Clementi C, Kuppler F, Brunner-Weinzierl MC, Freund C.   +11 more
europepmc   +1 more source

Characterizing antigen-specific CD4⁺ T cells using HLA-DR oligomers

, 2002
Thomas O. Cameron
openalex   +1 more source

Dynamic Regulation of Collagens, Proteases, Their Inhibitors, and Cell Death in Experimental Asthma in Mice

Allergy, Volume 81, Issue 1, Page 170-184, January 2026.
This study investigates airway remodeling in acute and chronic experimental asthma models induced by house dust mite extract to elucidate inflammatory and structural changes. Two acute T2‐low models demonstrated pronounced airway inflammation characterized by goblet cell hyperplasia, collagen deposition, and significant upregulation of extracellular ...
Marlena Tynecka, Agnieszka Tarasik, Bartosz Hanczaruk, Adrian Janucik, Krystian Czolpinski, Alicja Walewska, Arkadiusz Zbikowski, Anna Zeller, Agnieszka Kulczynska‐Przybik, Magdalena Niemira, Joanna Reszec‐Gielazyn, Barbara Mroczko, Adam Kretowski, Cezmi A. Akdis, Milena Sokolowska, Marcin Moniuszko, Cagatay Karaaslan, Andrzej Eljaszewicz   +17 more
wiley   +1 more source