Results 71 to 80 of about 188,808 (295)

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Estudo comparativo entre reação de Mitsuda e antígenos leucocitários humanos em pacientes hansenianos Comparative study between the Mitsuda test and the human leukocyte antigens in leprosy patients

Revista da Sociedade Brasileira de Medicina Tropical, 2007
Neste estudo, propomos comparar o teste cutâneo de Mitsuda e os alelos HLA-DR2/HLA-DR3 e HLA-DQ1 relacionados com as formas clínicas da hanseníase em 176 pacientes (50 TT, 50 LL e 76 B).
Fabiana Covolo de Souza, Elaine Valim Camarinha Marcos, Somei Ura, Paula Araújo Opromolla, Maria Esther Salles Nogueira   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

HLA-E: exploiting pathogen-host interactions for vaccine development [PDF]

Clinical and Experimental Immunology, 2019
SummaryViruses, when used as vectors for vaccine antigen delivery, can induce strong cellular and humoral responses against target epitopes. Recent work by Hansen et al. describes the use of a cytomegalovirus-vectored vaccine, which is able to generate a stable effector-memory T cell population at the sites of vaccination in rhesus macaques.
Sharpe, H, Bowyer, G, Brackenridge, S, Lambe, T   +3 more
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

O papel do complexo principal de histocompatibilidade na fisiologia da gravidez e na patogênese de complicações obstétricas Major histocompatibility complex: its role in the physiology of pregnancy and in the pathogenic mechanisms of obstetric complications

Revista Brasileira de Saúde Materno Infantil, 2007
Este trabalho tem por objetivo discutir a estrutura e função dos Antígenos Leucocitários Humanos (HLA), seus métodos de detecção, nomenclatura e os mecanismos imunopatológicos que o associam com a fisiologia da gestação e morbidades obstétricas.
Crésio Alves, Sâmia Veiga, Maria Betânia P. Toralles, Antônio Carlos Vieira Lopes   +3 more
doaj   +1 more source

Single Nucleotide and Copy-Number Variants in IL4 and IL13 Are Not Associated with Asthma Susceptibility or Inflammatory Markers: A Case-Control Study in a Mexican-Mestizo Population

Diagnostics, 2020
Background: Asthma is a complex and chronic inflammatory airway disease. Asthma’s etiology is unknown; however, genetic and environmental factors could affect disease susceptibility.
Enrique Ambrocio-Ortiz, Gustavo Galicia-Negrete, Gloria Pérez-Rubio, Areli J. Escobar-Morales, Edgar Abarca-Rojano, Alma D. Del Angel-Pablo, Manuel D. J. Castillejos-López, Ramcés Falfán-Valencia   +7 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Stability of the electron cyclotron resonance

, 2014
We consider the magnetic AC Stark effect for the quantum dynamics of a single particle in the plane under the influence of an oscillating homogeneous electric and a constant perpendicular magnetic field.
Asch, Joachim, Bourget, Olivier, Meresse, Cédric   +2 more
core   +3 more sources

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources