Results 61 to 70 of about 188,808 (295)

HLA-E-restricted cross-recognition of allogeneic endothelial cells by CMV-associated CD8 T cells: a potential risk factor following transplantation. [PDF]

PLoS ONE, 2012
Although association between CMV infection and allograft rejection is well admitted, the precise mechanisms involved remain uncertain. Here, we report the characterization of an alloreactive HLA-E-restricted CD8 T cell population that was detected in the
Mathilde Allard, Pierre Tonnerre, Steven Nedellec, Romain Oger, Alexis Morice, Yannick Guilloux, Elisabeth Houssaint, Béatrice Charreau, Nadine Gervois   +8 more
doaj   +1 more source

Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including [PDF]

, 2007
Background: The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association.
Charles E Larsen, Chester A Alper, Dennis R Alford, Dolores A Fici, Edmond J Yunis, Edward A Fox, Ingrid Almeciga, Joaquin Zuñiga, Jonathan S Duke-Cohan, Lama El-Dahdah, Olga P Clavijo, Tatiana Romero, Viviana Romero, Zaheed Husain, Zuheir L Awdeh   +14 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Antibodies to HLA-E in Nonalloimmunized Males: Pattern of HLA-Ia Reactivity of Anti–HLA-E–Positive Sera [PDF]

The Journal of Immunology, 2010
Abstract Natural anti-HLA Abs found in sera of healthy nonalloimmunized males recognize HLA-Ia alleles parallel to those recognized by anti–HLA-E mAbs (MEM-E/02/06/07). Therefore, some of the HLA-Ia Abs seen in healthy males could be due to anti–HLA-E Abs cross-reacting with HLA-Ia.
Mepur H, Ravindranath, Hugo, Kaneku, Nadim, El-Awar, Luis E, Morales-Buenrostro, Paul I, Terasaki   +4 more
openaire   +2 more sources

HLA-E circulating and genetic determinants in schizophrenia and bipolar disorder

Scientific Reports, 2021
Schizophrenia (SZ) and bipolar disorders (BD) are severe mental illnesses that lack reliable biomarkers to guide diagnosis and management. As immune dysregulation is associated with these disorders, we utilized the immunoregulatory functions of the ...
Wahid Boukouaci, Mohamed Lajnef, Jean-Romain Richard, Ching-Lien Wu, Jihène Bouassida, Ismail Rafik, Marianne Foiselle, Céline Straczek, Esma Mezouad, Soumia Naamoune, Sofiane Salah, Mohamed Amin Bencharif, Arij Ben Chaaben, Caroline Barau, Philippe Le Corvoisier, Marion Leboyer, Ryad Tamouza   +16 more
doaj   +1 more source

Enhancing Natural Killer and CD8 + T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 + T Cells with HLA-E Monospecific Monoclonal Antibodies [PDF]

, 2019
Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A.
Asgharzadeh, Shahab, Devarajan, Asokan, Filippone, Edward J., Ravindranath, Mepur H.   +3 more
core   +1 more source

HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia [PDF]

, 2017
Preeclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify dysregulated genes in maternal whole blood samples which may be ...
Akehurst, Christine, Carty, David M., Delles, Christian, Freeman, Dilys J., McBride, Martin W., McClure, John D., Robinson, Scott W., Sharafetdinova, Lilya, Small, Heather Y.   +8 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study Encefalomielite aguda disseminada: características clínicas e estudo de associação com os alelos HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602 e DPA1*0301

Arquivos de Neuro-Psiquiatria, 2009
We evaluated the frequency, demographic, clinical, disability evolution and genetic association of HLA DRB1*1501, DRB1*1503, DQA1*0102, DQB1*0602 and DPA1*0301 alleles in patients diagnosed as acute disseminated encephalomyelitis (ADEM) among a ...
Soniza Vieira Alves-Leon, Maria Lucia Veluttini-Pimentel, Maria Emmerick Gouveia, Fabíola Rachid Malfetano, Emerson L. Gaspareto, Marcos P. Alvarenga, Izabel Frugulhetti, Thereza Quirico-Santos   +7 more
doaj   +1 more source

Structure of a Pheromone Receptor-Associated MHC Molecule with an Open and Empty Groove [PDF]

, 2005
Neurons in the murine vomeronasal organ (VNO) express a family of class Ib major histocompatibility complex (MHC) proteins (M10s) that interact with the V2R class of VNO receptors.
Bjorkman, Pamela J., Dulac, Catherine, Huey-Tubman, Kathryn E., Olson, Rich   +3 more
core   +3 more sources