Results 91 to 100 of about 121,761 (316)

Estudo de associação entre antígenos leucocitários humanos e doença de Jorge Lobo Study of the association between human leukocyte antigens and Jorge Lobo's disease

Revista da Sociedade Brasileira de Medicina Tropical, 2005
A doença de Jorge Lobo é uma micose cutânea/subcutânea de evolução crônica, causada pelo fungo Lacazia loboi. Devido às características epidemiológicas e poucos estudos relacionados aos aspectos imunológicos dessa doença, o objetivo do trabalho foi ...
Elaine Valim Camarinha Marcos, Fabiana Covolo de Souza, Elza Araújo Torres, José Roberto Pereira Lauris, Diltor Vladimir de Araújo Opromolla   +4 more
doaj   +1 more source

HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet’s disease [PDF]

, 2007
The nonclassical human leukocyte antigen (HLA)-E and -G molecules have previously been shown to inhibit natural killer- and cytotoxic T-lymphocyte-mediated cell lysis and have also been shown to prevent the proliferation of CD4 T cells and secrete ...
방동식
core   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Human Urine Stem Cells Alleviate Pulmonary Fibrosis via Inhibiting Macrophage‐Myofibroblast Transition

Advanced Science, EarlyView.
Therapeutic role and mechanism of human urine stem cells (hUSCs) in pulmonary fibrosis. hUSCs alleviated pulmonary fibrosis by selectively inhibiting macrophage‐myofibroblast transition (MMT) in two ways: on one hand, hUSCs inhibited mitochondrial reactive oxygen species (mtROS) production and apoptosis/senescence of epithelial cells in pulmonary ...
Zhou‐Hang Zhang, Guan‐Lin Guo, Xiao‐Hui Guan, Min Hu, Qi‐Ming Huang, Ding‐Wen Guo, Hao‐Cheng Gu, You‐Qiong Zhuo, Ning Li, Hong‐Bo Xin, Ke‐Yu Deng   +10 more
wiley   +1 more source

Cross-Reactivity of Virus-Specific CD8+ T Cells Against Allogeneic HLA-C: Possible Implications for Pregnancy Outcome

Frontiers in Immunology, 2018
Heterologous immunity of virus-specific T cells poses a potential barrier to transplantation tolerance. Cross-reactivity to HLA-A and -B molecules has broadly been described, whereas responses to allo-HLA-C have remained ill defined.
Anita van der Zwan, Ellen M. W. van der Meer-Prins, Paula P. M. C. van Miert, Heleen van den Heuvel, Jacqueline D. H. Anholts, Dave L. Roelen, Frans H. J. Claas, Sebastiaan Heidt   +7 more
doaj   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

O sistema HLA
The HLA

Semina: Ciências Sociais e Humanas, 1981
Revisão bibliográfica, apresentando algumas características do complexo principal de histocompatibilidade humana (HLA). Discussão dos mecanismos mais prováveis para explicar as associações encontradas entre os antígenos do sistema HLA e algumas ...
Aldo Waldrigues
doaj  

INNOVATIVE STRATEGIES TO IDENTIFY M. TUBERCULOSIS ANTIGENS AND EPITOPES USING GENOME-WIDE ANALYSES

Frontiers in Immunology, 2014
In view of the fact that only a small part of the Mtb expressome has been explored for identification of antigens capable of activating human T-cell responses, which is critically required for the design of better TB vaccination strategies, more emphasis
Annemieke eGeluk, Krista E van Meijgaarden, Simone A Joosten, Susanna eCommandeur, Susanna eCommandeur, Tom H.M. Ottenhoff   +5 more
doaj   +1 more source

FcɛR1γ-based activating chimeric antigen receptor enhanced natural killer cell function against HLA-E+ cells

The Journal of Immunology
Abstract FcɛR1γ is a transmembrane adaptor protein that regulates the activating receptors NKp30, NKp46, and CD16 expression and function in human natural killer (NK) cells. HLA-E expression by cancer cells suppresses NK cell function through interaction with NKG2A.
Lewis L. Lanier, John R. Greenland, Frank Momburg, Daniel R. Calabrese, Avishai Shemesh   +4 more
openaire   +2 more sources