Results 71 to 80 of about 121,761 (316)

Characterization of antigen-specific B cells using nominal antigen-coated flow-beads. [PDF]

PLoS ONE, 2013
In order to characterize the reactivity of B cells against nominal antigens, a method based on the coupling of antigens onto the surface of fluorescent core polystyrene beads was developed.
Nicolas Degauque, Annie Elong Ngono, Ahmed Akl, Maud Lepetit, Romain Crochette, Magali Giral, Julie Lepourry, Annaick Pallier, Stéphanie Castagnet, Emilie Dugast, Cécile Guillot-Gueguen, Marylène Jacq-Foucher, Xavier Saulquin, Anne Cesbron, David Laplaud, Arnaud Nicot, Sophie Brouard, Jean-Paul Soulillou   +17 more
doaj   +1 more source

The role of HLA-B27 in inflammatory arthritis [PDF]

, 2009
Redacted electronic version excludes material for which permission has not been granted by the rights holderThe MHC class I allele, HLA-B27, is strongly associated with a group of inflammatory arthritic conditions collectively known as ...
Lynch, Sarah Janice
core  

Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [PDF]

, 2006
Cellular immune responses are an important correlate of hepatitis C virus (HCV) infection outcome. These responses are governed by the host's human leukocyte antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect of this host ...
Cheng, Wendy, Battegay, Manuel, E. Freitas, Weber, R., Furrer, H., Jeffrey, G., James, Ian, Park, Lawrence P, Swiss HIV Cohort Study,, G. Jeffrey, Battegay, M., Jeffrey, Gary, Herrmann, S., James, I., Weber, R., Battegay, M., Chapman, R., S. Herrmann, Furrer, Hansjakob, Telenti, Amalio, Freitas, E., Telenti, A., Lucas, M., M. Lucas, null null, I. James, Weber, Rainer, Telenti, A., Lucas, M., Freitas, Elizabeth, H. Furrer, Cheng, W., Jeffrey, G., Gaudieri, S., S. A. Mallal, Park, P., Freitas, E., Cheng, W., K. Pfafferott, Pfafferott, K., S. Gaudieri, R. Weber, Naidoo, Kiloshni, A. Rauch, Pfafferott, K., Mallal, Simon A, L. P. Park, Rauch, A., Chapman, R., A. Telenti, Pfafferott, Katja, R. Chapman, Lucas, Michaela, M. Battegay, Park, L.P., Naidoo, K., Herrmann, Susan, K. Naidoo, Furrer, H., Rauch, Andri, Park, L. P., W. Cheng, Herrmann, S., Naidoo, K., Chapman, Russell, Rauch, A., Mallal, S.A., Gaudieri, S., Mallal, S. A., James, I., Gaudieri, Silvana   +70 more
core   +2 more sources

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source

HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas

Journal of Immunology Research, 2014
Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer ...
M. J. Rutten, F. Dijk, C. D. Savci-Heijink, M. R. Buist, G. G. Kenter, M. J. van de Vijver, E. S. Jordanova   +6 more
doaj   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Identification and biophysical characterization of Plasmodium peptide binding by common African HLAs

Scientific Reports
Human Leukocyte Antigens (HLA) are immunoreceptors that present peptide antigens at the cell surface to T cells as a primary mechanism of immune surveillance.
Marielle B. Frooman, Klara Choi, Maya Z. Kahn, Li-Yen Yang, Aubrielle Cunningham, Jenna M. RisCassi, Andrew C. McShan   +6 more
doaj   +1 more source

Association between HLA-E gene polymorphism and unexplained recurrent spontaneous abortion (RSA) in Iranian women [PDF]

Iranian Journal of Reproductive Medicine, 2016
Background: Human leukocyte antigen-E (HLA-E)is a non-classical major histocompatibility complex (MHC) class I antigens which expressed on extra villous cytotrophoblast, which interacts with NKG2A, is an inhibitory receptor on natural killer (NK) cells ...
Maryam Fotoohi, Nasrin Ghasemi, Seyed Ali Mirghanizadeh, Mahmood Vakili, Morteza Samadi   +4 more
doaj  

HLA and skin cancer HLA e câncer de pele

Anais Brasileiros de Dermatologia, 2012
Skin cancer - melanoma and non melanoma - are common neoplasm with rising incidence over the last decades. It is an important public health problem. Its pathogenesis is not completely understood and the same happens with the genetic factors involved. The
Renan Rangel Bonamigo, André Vicente Esteves de Carvalho, Vanessa Raquel Zaleski Sebastiani, Cristina Martino da Silva, Angela Caroline de Zorzi Pinto   +4 more
doaj   +1 more source

Genetic Variants in Nonclassical Major Histocompatibility Complex Class I Human Leukocyte Antigen (HLA)–E and HLA‐G Molecules Are Associated with Susceptibility to Heterosexual Acquisition of HIV‐1 [PDF]

The Journal of Infectious Diseases, 2006
Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of the innate immune response. The present study shows that the HLA-E(G) genetic variant (the HLA-E*0103 allele) alone is significantly (P = .001) associated with a 4.0-fold decreased risk of human immunodeficiency virus 1 (HIV-1) infection in Zimbabwean women.
Julie, Lajoie, John, Hargrove, Lynn S, Zijenah, Jean H, Humphrey, Brian J, Ward, Michel, Roger   +5 more
openaire   +2 more sources