Results 51 to 60 of about 121,761 (316)

Aloimunidade contra antígenos HLA de classe I em pacientes com síndromes mielodisplásicas e anemia aplástica Aloimmunity against HLA class I antigens in patients with myelodisplastic syndrome and aplastic anemia

Revista Brasileira de Hematologia e Hemoterapia, 2008
As síndromes mielodisplásicas (SMD) e a anemia aplástica (AA) apresentam citopenias periféricas necessitando, com freqüência, de reposições transfusionais contínuas de concentrados de hemácias e/ou de concentrados de plaquetas.
Daisy M. M. Arruda, Silvia F. R. Silva, Sônia L. Silva, Maria Helena Pitombeira, Henry H. Campos, Rosa M. S. Mota, Talapala G. Naidu   +6 more
doaj   +1 more source

Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? [PDF]

, 2006
Background: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied.
Smith, AD, Horton Roger, Barnardo Martin CNM, Stephan Beck, Warden Donald R, Warden, DR, Martin CNM Barnardo, Barnetson, L, Smith A David, Andrew Sutherland, Lehmann, DJ, Beck Stephan, Barnardo, MC, Isabel Quiroga, Fuggle Susan, Barnetson Lin, Barnardo, MCNM, Quiroga Isabel, Lehmann Donald J, Roger Horton, Beck, S, Susan Fuggle, Donald R Warden, Fuggle, S, Sutherland Andrew, Sutherland, A, Donald J Lehmann, Lin Barnetson, A David Smith, Quiroga, I, Horton, R   +30 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Polimorfismos da região 3' não traduzida do gene HLA-G em pacientes com câncer de mama e controles no estado de Santa Catarina [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Biologia Celular e do DesenvolvimentoO câncer de mama é o segundo tipo de câncer mais frequente no mundo e de maior prevalência ...
Silva, Mariáh Damiani da
core  

Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination. [PDF]

, 2007
Mycobacterium bovis BCG is widely used as a vaccine against tuberculosis (TB), despite its variable protective efficacy. Relatively little is known about the immune response profiles following BCG vaccination in relation to protection against TB. Here we
Klein, Michèl R, Friggen, Annemieke H, Geluk, Annemieke, Lin, May Young, Verduyn, Marleen JC, Voskuil, Martin I, Huygen, Kris, Franken, Kees LMC, Smith, Steven G, van Meijgaarden, Krista E, Dockrell, Hazel M, Stewart, Amanda L, Ottenhoff, Tom HM   +12 more
core   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Aspectos genéticos da esclerose múltipla: II. sistema HLA Genetic aspects in multiple sclerosis: HLA system

Arquivos de Neuro-Psiquiatria, 1996
Foi feita análise e revisão de estudos populacionais de associação entre antígenos HLA e a esclerose múltipla (EM). Há evidências de que os genes HLA, principalmente os de classe II, das sub-regiões DR e DQ possam estar envolvidos.
Patrícia Almeida de Rezende, Walter Oleschko Arruda   +1 more
doaj   +1 more source

HLA-B*35-restricted CD8 T cell epitopes in the antigen 85 complex of Mycobacterium tuberculosis. [PDF]

, 2001
Few target epitopes have been described for human CD8 T lymphocytes in antigens of Mycobacterium tuberculosis. By use of a reverse immunogenetics approach, 23 motif-bearing peptides of the Ag85 complex were tested for binding to HLA-B*35, one of the ...
Ogg, GS, Jaye, A, Klein, MR, Lukey, PT, Hammond, AS, King, AS, McAdam, KP, Vekemans, J, Smith, SM   +8 more
core   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Quantificação de antígenos HLA classe I solúveis pela técnica de ELISA = Quantification of soluble HLA class I antigens by ELISA assay

Acta Scientiarum. Health Sciences, 2009
As moléculas HLA (Human Leucocyte Antigens) são consideradas,principalmente, estruturas de superfície celular envolvidas em uma variedade de reações imunes associadas com transplante, infecções e doenças autoimunes.
Elisiane Coan Boian, Renato Marques de Andrade, Lílian Yurie Nakamura, André Luiz Medeiros, Marciele Coan Boian, Sueli Donizete Borelli   +5 more
doaj