Results 41 to 50 of about 121,761 (316)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Infection of human endothelial cells by Japanese encephalitis virus: increased expression and release of soluble HLA-E.

PLoS ONE, 2013
Japanese encephalitis virus (JEV) is a single stranded RNA virus that infects the central nervous system leading to acute encephalitis in children. Alterations in brain endothelial cells have been shown to precede the entry of this flavivirus into the ...
Shwetank, Onkar S Date, Kwang S Kim, Ramanathapuram Manjunath   +3 more
doaj   +1 more source

HLA class II alleles as markers of tuberculosis susceptibility and resistance

Revista Portuguesa de Pneumologia, 2011
Background: Not every individual exposed to Mycobacterium tuberculosis becomes infected. One host genetic factor, involved in modulating the immune response that has been studied in many ethnic groups is the association of human leukocyte antigens (HLA ...
R. Duarte, C. Carvalho, C. Pereira, A. Bettencourt, A. Carvalho, M. Villar, A. Domingos, H. Barros, J.A. Marques, P. Pinho Costa, D. Mendonça, B. Martins   +11 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Is HLA-E with its receptors an immune checkpoint or an antigenic determinant in allo-HCT?

Best Practice & Research Clinical Haematology
Hematopoietic cell transplantation (HCT) represents a potentially curative therapeutic approach for various hematologic and non-hematologic malignancies. Human leukocyte antigen (HLA) matching is still the central selection criterion for HCT donors. Nevertheless, post-transplant complications, in particular graft-versus-host disease (GvHD), relapse of ...
Hana, Rohn, Vera, Rebmann
openaire   +2 more sources

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA‐E during active tuberculosis and express type 2 cytokines [PDF]

European Journal of Immunology, 2015
CD8 T cells contribute to protective immunity against Mycobacterium tuberculosis. In humans, M. tuberculosis reactive CD8 T cells typically recognize peptides associated to classical MHC class Ia molecules, but little information is available on CD8 T cells recognizing M. tuberculosis Ags presented by nonclassical MHC class Ib molecules.
Caccamo, N., Pietra, G., Sullivan, L.C., Brooks, A.G., Prezzemolo, T., Manna, M.P. la, Liberto, D. di, Joosten, S.A., Meijgaarden, K.E. van, Carlo, P. di, Titone, L., Moretta, L., Mingari, M.C., Ottenhoff, T.H.M., Dieli, F.   +14 more
openaire   +4 more sources

Human leukocyte antigen HLA-C, HLA-G, HLA-F, and HLA-E placental profiles are altered in early severe preeclampsia and preterm birth with chorioamnionitis

American Journal of Obstetrics and Gynecology, 2022
The extravillous trophoblast expresses each of the nonclassical major histocompatibility complex class I antigens-human leukocyte antigens E, F, and G-and a single classical class I antigen, human leukocyte antigen C. We recently demonstrated dynamic expression patterns of human leukocyte antigens C, G, and F during early extravillous trophoblast ...
Caroline E. Dunk, Matthew Bucher, Jianhong Zhang, Heyam Hayder, Daniel E. Geraghty, Stephen J. Lye, Leslie Myatt, Rinat Hackmon   +7 more
openaire   +2 more sources

Polimorfismos do gene HLA-G em pacientes com psoríase [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento.A psoríase é uma doença inflamatória crônica, de etiologia desconhecida, que afeta a pele e
Almeida, Bibiana Sgorla de
core  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the CARRA, SPARTAN, and PRCSG Advisory Council   +9 more
wiley   +1 more source

Peculiarities of HLA-phenotypes in patients with pyelonephritis

Annals of Mechnikov's Institute, 2020
Introduction. Of great interest are the studies on the role of human leucocyte antigens (HLA) in pathogenesis of a disease. The kidneys is vulnerable to injury in the context of inflammatory responses, with the potential involvement of a number of ...
F Haiseniuk, V Driyanska, V Kruglikov
doaj