Results 31 to 40 of about 121,761 (316)

The Rapid Induction of HLA-E Is Essential for the Survival of Antigen-Activated Naive CD4 T Cells from Attack by NK Cells [PDF]

The Journal of Immunology, 2010
Abstract Increasing evidence shows that NK cells regulate adaptive immunity, but the underlying mechanisms are not well understood. In this study, we show that activated human NK cells suppress autologous naive CD4 T cell proliferation in response to allogeneic dendritic cells (DCs) by selectively killing Ag-activated T cells.
Sumiko, Takao, Takayuki, Ishikawa, Kouhei, Yamashita, Takashi, Uchiyama   +3 more
openaire   +2 more sources

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection [PDF]

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
core   +2 more sources

A Physical Map Including a New Class I Gene (cda12) of the Human Major Histocompatibility Complex (A2/313 Haplotype) Derived from a Monosomy 6 Mutant Cell Line [PDF]

, 1989
To avoid interpretative problems due to restriction fragment length polymorphisms, the monosomy 6 mutant cell line BM19.7 was employed to establish a molecular map of the human major histocompatibility (HLA) complex in the A2,B13,Bw4,DRw6,DRw52,DQw1,DPw2
Pohla, Heike, Bloemer, K, Messer, Gerald, Bloemer, Katharina, Messer, G, Ziegler, Andreas, Ragoussis, Jiannis, Ragoussis, J, Weiss, Elisabeth H., Pohla, H, Weiss, EH, Ziegler, A   +11 more
core   +1 more source

CD8 ⁺ T cell targeting of tumor antigens presented by HLA-E

Science Advances
The nonpolymorphic major histocompatibility complex E (MHC-E) molecule is up-regulated on many cancer cells, thus contributing to immune evasion by engaging inhibitory NKG2A/CD94 receptors on NK cells and tumor-infiltrating T cells. To investigate whether MHC-E expression by cancer cells can be targeted for MHC-E–restricted T cell control,
Ravi F. Iyer, Marieke C. Verweij, Sujit S. Nair, David Morrow, Mandana Mansouri, Dimple Chakravarty, Teresa Beechwood, Christine Meyer, Luke Uebelhoer, Elvin J. Lauron, Andrea Selseth, Nessy John, Tin Htwe Thin, Siarhei Dzedzik, Colin Havenar-Daughton, Michael K. Axthelm, Janet Douglas, Alan Korman, Nina Bhardwaj, Ashutosh K. Tewari, Scott Hansen, Daniel Malouli, Louis J. Picker, Klaus Früh   +23 more
openaire   +2 more sources

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease [PDF]

, 2012
Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number of known HBV-specific T-cell epitopes is limited, and it is not clear whether viral evolution occurs in chronic HBV infection. We aimed to
Chopra, A., Gordon, A, Scott Bowden, Pfafferott, K, Desmond, P.V., Ian R. James, Revill, P.A., Chopra, A, Mallal, SA, Silvana Gaudieri, Anna Ayres, Lewin, S.R., Thompson, AJ, Desmond, C.P., Jennifer Audsley, James, IR, Locarnini, SA, Stephen A. Locarnini, Sharon R. Lewin, James, I.R., Locarnini, S.A., Chivers, S., Christopher P. Desmond, Desmond, PV, Thompson, A.J., Stuart K. Roberts, Audsley, J, Revill, PA, Lau, GK, Gaudieri, S, Gaudieri, S., Audsley, J., Day, C, Caroline Day, Ayres, A, Day, C., Paul V. Desmond, Pfafferott, K., Gordon, A., Roberts, SK, Peter A. Revill, Alexander J. Thompson, Ayres, A., Desmond, CP, Sarah Chivers, Katja Pfafferott, Bowden, S., George K. Lau, Simon A. Mallal, Lewinb, SR, Lau, G.K., Roberts, S. K., Abha Chopra, Bowden, S, Mallal, S.A., Adam Gordon, Chivers, S   +56 more
core   +2 more sources

HLA-E: A Novel Player for Histocompatibility

Journal of Immunology Research, 2014
The classical class I human leukocyte antigens (HLA-A, -B, and -C) present allele-specific self- or pathogenic peptides originated by intracellular processing to CD8+ immune effector cells. Even a single mismatch in the heavy chain (hc) of an HLA class I
Thomas Kraemer, Rainer Blasczyk, Christina Bade-Doeding   +2 more
doaj   +1 more source

Antibodies for β2-Microglobulin and the Heavy Chains of HLA-E, HLA-F, and HLA-G Reflect the HLA-Variants on Activated Immune Cells and Phases of Disease Progression in Rheumatoid Arthritis Patients under Treatment

Antibodies, 2023
Rheumatoid arthritis (RA) is a progressive, inflammatory, autoimmune, symmetrical polyarticular arthritis. It is characterized by synovial infiltration and activation of several types of immune cells, culminating in their apoptosis and antibody ...
Mepur H. Ravindranath, Narendranath M. Ravindranath, Carly J. Amato-Menker, Fatiha El Hilali, Senthamil R. Selvan, Edward J. Filippone, Luis Eduardo Morales-Buenrostro   +6 more
doaj   +1 more source

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

NOT gated T cells that selectively target EGFR and other widely expressed tumor antigens

iScience
Summary: Here, we show that a NOT gated cell therapy (Tmod) can exploit antigens such as epidermal growth factor receptor (EGFR) and human leukocyte antigen-E (HLA-E) which are widely expressed on cancer cells.
Julyun Oh, Charles Kirsh, Jing-Ping Hsin, Kelly C. Radecki, Alexandre Zampieri, Diane Manry, Yuta Ando, Sara Miller, Jamie Chan, Ethan McLeod, Kathleen M. Cunningham, Lu Min Wong, Han Xu, Alexander Kamb   +13 more
doaj   +1 more source