Results 221 to 230 of about 84,983 (267)

Single-cell dissection of persistent tumor antigens in non-responders reveals opportunities for TAA-targeted vaccination after neoadjuvant therapy in esophageal squamous cell carcinoma. [PDF]

J Immunother Cancer
Zhang R, Qi S, Zhou Y, Hu Y, Li Y, Li Y, Qin J, Yang AR, Zhang H, Liu Z, Li Y.   +10 more
europepmc   +1 more source

PICALM regulates a human microglial antigen presentation program in Alzheimer’s disease

De Strooper B, Borrie S, Pasciuto E, Moortel LV, Willems P, Moechars D, Thrupp N, Bourdely P, Snellinx A, T'Syen D, Li R, Lloyd A, Geary B, De Baene H, Albertini G, Sirvent DÁ, Mekkes N, Holtman I, Holstege H, Malysheva V, Mazzone M, Impens F, Fiers M, Sierksma A.   +23 more
europepmc   +1 more source

Gene-Environment Interactions in Celiac Disease: The Role of the Intestinal Epithelium.

Lifestyle Genom
Rahmani S, Mas-Orea X, Chirdo FG, Verdu EF.   +3 more
europepmc   +1 more source

The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells

The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells
openaire  

Expression of classical human leukocyte antigen class I antigens, HLA‐E and HLA‐G, is adversely prognostic in pancreatic cancer patients [PDF]

Cancer Science, 2020
AbstractThe expression of classical human leukocyte antigen class I antigens (HLA‐I) on the surfaces of cancer cells allows cytotoxic T cells to recognize and eliminate these cells. Reduction or loss of HLA‐I is a mechanism of escape from antitumor immunity.
Satoshi Nara, Toshihiko Torigoe, Nobuyoshi Hiraoka   +2 more
exaly   +3 more sources

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Malaria antigens are presented to CD8 T cells via the non-classical HLA-E

The Journal of Immunology, 2022
Abstract CD8 T cells have long been known to target infected hepatocytes during the intracellular liver stages of Plasmodium—the causative agent of malaria. Current T cell vaccine strategies are limited by the inability to obtain sufficient amounts of Plasmodium-infected hepatocytes to identify peptides presented on MHC-I ...
Brandon Keith Wilder, Luna de Lacerda, Camila R R Barbosa, Maya Aleshnick, Thomas Martinson, David Morrow, Zeshou Zhao, Gaurav Gaiha, Caroline Junqueira   +8 more
openaire   +1 more source

Capturing the antigen landscape: HLA-E, CD1 and MR1

Current Opinion in Immunology, 2019
T cell receptor (TCR) recognition of antigens presented by relatively non-polymorphic MHC-like molecules is emerging as a significant contributor to health and disease. These evolutionarily ancient pathways have been inappropriately labelled 'non-conventional' because their roles were discovered after viral-specific peptide presentation by polymorphic ...
Graham, Ogg, Vincenzo, Cerundolo, Andrew J, McMichael   +2 more
openaire   +2 more sources

Antigen-specific memory NK cell responses against HIV and influenza use the NKG2/HLA-E axis

Science Immunology, 2023
Multiple studies have broadened the roles of natural killer (NK) cells functioning as purely innate lymphocytes by demonstrating that they are capable of putative antigen-specific immunological memory against multiple infectious agents including HIV-1 and influenza. However, the mechanisms underlying antigen specificity remain unknown.
Stephanie Jost, Olivier Lucar, Esther Lee, Taylor Yoder, Kyle Kroll, Sho Sugawara, Scott Smith, Rhianna Jones, George Tweet, Alexandra Werner, Phillip J. Tomezsko, Haley L. Dugan, Joshua Ghofrani, Philippe Rascle, Marcus Altfeld, Michaela Müller-Trutwin, Paul Goepfert, R. Keith Reeves   +17 more
openaire   +2 more sources

Human Antigen Leucocyte (HLA)-G and HLA-E are differentially expressed in pancreatic disorders

Human Immunology, 2019
Little information is available regarding the expression of the immunomodulatory Human Leukocyte Antigen (HLA)-G and -E molecules in pancreatic disorders.To analyze HLA-G and -E expression in specimens of alcoholic chronic pancreatitis (ACP), idiopathic chronic pancreatitis (ICP), type 1 (T1D) and type 2 diabetes (T2D) and in histologically normal ...
Bruna Cristina, Bertol, Fabrício César, Dias, Deisy Mara, da Silva, Leandra Náira, Zambelli Ramalho, Eduardo Antônio, Donadi   +4 more
openaire   +2 more sources