Results 231 to 240 of about 84,983 (267)

Interaction of HLA-E with Peptides and the Peptide Transporter In Vitro: Implications for its Function in Antigen Presentation

The Journal of Immunology, 1998
Abstract The assembly of MHC Ia molecules in the endoplasmic reticulum requires the presence of peptide ligands and β2m and is facilitated by chaperones in an ordered sequence of molecular interactions. A crucial step in this process is the interaction of the class I α-chain/β2m dimer with TAP, which is believed to ensure effective ...
M, Ulbrecht, S, Modrow, R, Srivastava, P A, Peterson, E H, Weiss   +4 more
openaire   +2 more sources

Nonclassical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease

Human Immunology, 2016
Several evidences suggest the association between the evolution of coronary artery disease (CAD) and the development of coronary syndrome that is often associated with disrupted plaque and partial or complete thrombosis of the related artery. Because of the inflammatory nature of CAD, we investigated the human leukocyte antigen (HLA)-G, HLA-E, and HLA ...
Zidi, Ines, Kharrat, Najla, Abdelhedi, Rania, Hassine, Amna Ben, Laaribi, Ahmed Baligh, Yahia, Hamza Ben, Abdelmoula, Nouha Bouayed, Abid, Leila, Rebai, Ahmed, RIZZO, Roberta   +9 more
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Human leukocyte antigen (HLA)-E and HLA-G polymorphisms in human papillomavirus infection susceptibility and persistence

Human Immunology, 2011
Human leukocyte antigen (HLA)-E and HLA-G molecules act as powerful modulators of innate and adaptive immune responses. The study examined whether HLA-E and/or HLA-G polymorphisms are associated with human papillomavirus (HPV) infection susceptibility and persistence in 636 female university students in Montreal.
Rhea, Ferguson, Agnihotram V, Ramanakumar, Harriet, Richardson, Pierre-Paul, Tellier, François, Coutlée, Eduardo L, Franco, Michel, Roger   +6 more
openaire   +2 more sources

The placental expression of Human Leukocyte Antigen HLA-F and HLA-E in early normal placentation

Placenta, 2013
s / Placenta 34 (2013) A1–A99 A75 rate, but clones were significantly smaller. The onset of yolk-sac development was not normal in clones. In addition, later steps differed from the condition in vivo in all three groups in that the yolk-sac was yellowish and juxtaposed with the amnion. Vascularisation of the chorioallantoic membrane was relatively late
Rinat Hackmon, Lakmini Pinnaduwage, John Kingdom, Gideon Koren, Dan Geraghty, Stephen Lye, Caroline Dunk   +6 more
openaire   +1 more source

Human influenza-specific adaptive NK cells mediate potent HLA-E-restricted responses against antigenically distinct influenza strains

The Journal of Immunology, 2020
Abstract Novel influenza vaccine approaches to achieve cross-protection against a broad range of antigenically distinct strains are needed. Beyond their ability to eliminate infected cells without the need for prior sensitization, natural killer (NK) cells have been shown to mediate virus-specific recall responses.
Stephanie Jost, Olivier Lucar, Taylor Yoder, Alexandra Werner, Joshua Ghofrani, R Keith Reeves   +5 more
openaire   +1 more source

Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer.

Anticancer research, 2015
Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study.
Sumiya, Ishigami, Takaaki, Arigami, Hiroshi, Okumura, Yasuto, Uchikado, Yoshiaki, Kita, Hiroshi, Kurahara, Kosei, Maemura, Yuko, Kijima, Yuka, Ishihara, Ken, Sasaki, Yoshikazu, Uenosono, Shoji, Natsugoe   +11 more
openaire   +1 more source

Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients

The Journal of Immunology, 1992
Abstract A cDNA library, constructed from purified blood eosinophils, was screened with the B cell CD23 cDNA probe. A clone designated EO15 has been isolated and found to encode a non-classical HLA class I gene transcript. EO15 was compared with HLA-E and found to be 99.9% similar at the nucleotide level and to extend further in the 3’
Truong, M., Gruart, V, Capron, A., Capron, M., Tourvieille, B   +4 more
openaire   +3 more sources

HPLC and MS Analysis for the Identification and Characterisation of Peptides Presented in the Context of the Non-Classical Human Leukocytes Antigen (HLA) Class I Molecule HLA-E

Current Pharmaceutical Design, 2009
In addition to a variety of other techniques used in T-cell epitope identification, mass spectrometery coupled to liquid chromatography have now become an important and sensitive tool in separation, detection, and sequence analysis of highly complex natural major histocompatibility complex (MHC) ligand mixtures.
MILLO, ENRICO, DAMONTE, GIANLUCA
openaire   +3 more sources

CXCR2-mediated recruitment of adaptive NK cells with NKG2C/HLA-E dependent antigen-specific memory enhances tumor killing in ovarian cancer

Abstract Natural killer (NK) cells have emerged as promising effectors in cancer immunotherapy due to their ability to recognize and eliminate tumor cells. To investigate the immunological memory and tumor reactivity of adaptive (a)NK cells in the context of desmoplastic tumors, we used human ovarian cancer as a model.
Yizhe Sun, Andrea Rodgers-Furones, Okan Gultekin, Shruti Khare, Shi Yong Neo, Wenyang Shi, Lidia Moyano Galceran, Kong-Peng Lam, Ramanuj Dasgupta, Jonas Fuxe, Sahar Salehi, Kaisa Lehti, Dhifaf Sarhan   +12 more
openaire   +1 more source

The non-classical antigens of HLA-G and HLA-E as diagnostic and prognostic biomarkers and as therapeutic targets in transplantation and tumors.

Clinical transplants, 2014
The non-classical human leukocyte antigen (HLA) class I antigen HLA-G represents a tolerogenic molecule and is involved in the inhibition of natural killer cell and cytotoxic T lymphocyte-mediated cytotoxicity. Under physiological conditions, HLA-G expression is mainly restricted to immune-privileged tissues, whereas it is overexpressed in tumors and ...
openaire   +1 more source