Results 111 to 120 of about 170,658 (215)

HLA-G in Hematological Malignancies: Immunoregulatory Mechanisms and Implications for Immune Evasion and Immunotherapy. [PDF]

J Immunol Res
Ribeiro TLCP, Nogueira GM, Souza-Barros M, Moraes JS, Santos LS, Oliveira LS, Crespo-Neto JA, Ghedini JGS, Magalhães-Gama F, Malheiro A, Alves-Hanna FS, Costa AG.   +11 more
europepmc   +1 more source

T Cell Plasticity in Systemic Lupus Erythematosus Revealed by Large‐Scale T Cell Receptor Repertoire and Transcriptome Studies

Arthritis &Rheumatology, EarlyView.
Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi, Masahiro Nakano, Kaitlyn A. Lagattuta, Mineto Ota, Hiroaki Hatano, Haruka Takahashi, Takahiro Itamiya, Hajime Inokuchi, Soumya Raychaudhuri, Tomohisa Okamura, Keishi Fujio, Kazuyoshi Ishigaki   +11 more
wiley   +1 more source

Unlocking the promise of innate biology through the HLA-G/ILT2/ILT4 pathway. [PDF]

J Immunother Cancer
Beers C, Ilaria RL, Luke JJ.
europepmc   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Editorial: HLA-G in health and disease: comprehensive insights and future therapeutic directions. [PDF]

Front Immunol
Russick J, Rizzo R, Ajith A.
europepmc   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Soluble HLA-G is related to malignant melanocytic lesions and previous oncological disease may increase circulating HLA-G bearing large extracellular vesicles. [PDF]

Front Immunol
Silva-Krebs KK, de Oliveira EM, Athayde CA, da Fonseca PB, De Felice FG, Carvalho FR, Sá Araújo M, Luz FB, Silva AA, Pantaleão L, Medeiros T, Dayse-Silva IL.   +11 more
europepmc   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

HLA-G, IL-6 and TGF-β in Seminal Plasma as Potential Biomarkers of ART Outcome. [PDF]

Am J Reprod Immunol
Schallmoser A, Emrich N, Masslow L, Allam JP, Einenkel R, Sänger N.   +5 more
europepmc   +1 more source

The role of IgM anti‐acetylated protein antibodies and B cells in the origin of anti‐modified protein autoimmunity in rheumatoid arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Rheumatoid arthritis (RA) is characterized by anti‐modified protein antibodies (AMPAs), including anti‐citrullinated (ACPA), anti‐carbamylated (anti‐CarP), and anti‐acetylated (AAPA) protein antibodies. In contrast to other AMPAs, AAPA IgM is found in healthy individuals, raising questions about its role in early immune responses.
Aegli Athanasiadou, Sanne Kroos, Renee van de Wetering, Rian Schopmeijer, Carin van der Keur HLO, Michael Eikmans, Caroline Meijer, Solbritt Rantapää‐Dahlqvist, René E.M. Toes, Linda M. Slot, Diane van der Woude   +10 more
wiley   +1 more source