Results 211 to 220 of about 171,039 (261)
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Trends in Immunology, 2008
Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class-I molecule that was found to be expressed by placental trophoblast cells 20 years ago. Because trophoblast forms the physical interface between fetus and mother, HLA-G might play a role in maternal immunological accommodation of the semi-allogeneic fetus.
Richard, Apps +2 more
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Human leukocyte antigen-G (HLA-G) is a nonclassical HLA class-I molecule that was found to be expressed by placental trophoblast cells 20 years ago. Because trophoblast forms the physical interface between fetus and mother, HLA-G might play a role in maternal immunological accommodation of the semi-allogeneic fetus.
Richard, Apps +2 more
openaire +2 more sources
Retinoblastoma: Expression of HLA-G
Ocular Immunology and Inflammation, 2006Human leukocyte antigen (HLA) mediates interactions of tumor cells with cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Retinoblastoma (RB) is the most common intraocular malignant tumor in childhood and is characterized by direct spread to the optic nerve and orbit as well as hematogenous and lymphatic spread.
Mohan, Adithi +5 more
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HLA-G and Inflammatory Diseases
Inflammation & Allergy-Drug Targets, 2008HLA-G antigens are non classical HLA-class I molecules characterized by a low allelic polymorphism, a limited tissue distribution and the presence of membrane bound and soluble isoforms. The HLA-G antigens were firstly detected in cytotrophoblast cells at the feto-maternal interface where they maintain a tolerogenic status between the mother and the ...
BARICORDI, Olavio +3 more
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American Journal of Reproductive Immunology, 2001
PROBLEM: It has been proposed that the expression of the non‐classical MHC class I antigen, HLA‐G, by trophoblast is one mechanism by which the placenta evades attack by maternal uterine NK cells. A similar mechanism is thought to be operative in the escape from immunosurveillance by tumor cells.
B, Davies +4 more
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PROBLEM: It has been proposed that the expression of the non‐classical MHC class I antigen, HLA‐G, by trophoblast is one mechanism by which the placenta evades attack by maternal uterine NK cells. A similar mechanism is thought to be operative in the escape from immunosurveillance by tumor cells.
B, Davies +4 more
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HLA-G and lymphoproliferative disorders
Seminars in Cancer Biology, 2003The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii)
Laurence, Amiot +9 more
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HLA-G as predisposing for metastasis
Medical Hypotheses, 2011HLA-G, a very conserved non-classical class I human leukocyte antigen, is highly expressed in cancer pathologies. Recent evidences about HLA-G implication in immune tolerance announce the probable association between HLA-G and metastasis. We highlighted here possible mechanisms for link between HLA-G regulation and cascade metastasis including ...
Ines, Zidi, Nidhal, Ben Amor
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Journal of Reproductive Immunology, 1999
We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
A, Mellor, M, Zhou, S J, Conway, D, Munn
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We have generated a number of transgenic mice using DNA segments derived from the HLA-G gene. Using these mice we have examined the pattern of expression dictated by HLA-G promoter elements in mice and shown that HLA-G functions both as a restriction element and a transplantation antigen recognized by murine T cells.
A, Mellor, M, Zhou, S J, Conway, D, Munn
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Immunotolerant functions of HLA-G
Cellular and Molecular Life Sciences (CMLS), 1999HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the fetal-maternal interface, where it plays a role in materno-fetal tolerance. In contrast to classical HLA-A, -B and -C class I molecules, HLA-G is characterized by (i) a tissue-restricted distribution, (ii) a limited polymorphism ...
E D, Carosella +2 more
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The functionality of HLA‐G is emerging
Immunological Reviews, 1999Summary: In view of the recently published data, the HLA‐G class Ib gene appears to be a functional locus. This is based on the following observations: 1) HLA‐G is capable of presenting nonamer peptides and of exerting antigen‐presenting functions; 2) HLA‐G is a ligand for at least three natural killer (NK) and other cell inhibitory receptors of the ...
P, Le Bouteiller, A, Blaschitz
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HLA-G polymorphisms and HLA-G expression in sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2006The MHC class Ib molecule Human Leukocyte Antigen (HLA)-G may be important in induction and maintenance of immunological tolerance, and HLA-G expression may have a role in different cancers, in certain diseases with associations to HLA, and in organ transplantation.
Hviid, Thomas Vauvert F +5 more
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