Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection [PDF]
, 2013 Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses.
Li, Chun +8 more
core +4 more sources
Tolerogenic function of dimeric forms of HLA-G recombinant proteins: a comparative study in vivo. [PDF]
PLoS ONE, 2011 HLA-G is a natural tolerogenic molecule involved in the best example of tolerance to foreign tissues there is: the maternal-fetal tolerance. The further involvement of HLA-G in the tolerance of allogeneic transplants has also been demonstrated and some ...
Benoit Favier +7 more
doaj +1 more source
Linking Two Immuno-Suppressive Molecules: Indoleamine 2,3 Dioxygenase Can Modify HLA-G Cell-Surface Expression1 [PDF]
, 2005 Nonclassical human leukocyte antigen (HLA) class I molecule HLA-G and indoleamine 2,3 dioxygenase (INDO) in humans and mice, respectively, have been shown to play crucial immunosuppressive roles in fetal-maternal tolerance.
Alegre-Martinez, E. (Estibaliz) +8 more
core +1 more source
HLA-G Expressing Immune Cells in Immune Mediated Diseases
Frontiers in Immunology, 2020 HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with ...
Paola Contini +3 more
semanticscholar +1 more source
Expression of HLA-G in inflammatory bowel disease provides a potential way to distinguish between ulcerative colitis and Crohn's disease. [PDF]
, 2004 In addition to being involved in nutrient uptake, the epithelial mucosa constitute the first line of defense against microbial pathogens. A direct consequence of this physiological function is a very complex network of immunological interactions that ...
Carosella, E. D. +8 more
core +4 more sources
Expression of HLA-G in patients with B-cell chronic lymphocytic leukemia (B-CLL).
Folia Histochemica et Cytobiologica, 2009 The expression of HLA-G was reported in certain malignancies and its role in escaping from immunosurveillance in cancers was proposed since HLA-G is a nonconventional HLA class I molecule that protects fetus from immunorecognition during pregnancy ...
M Schmitt +4 more
doaj +1 more source
Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Fetal extravillous trophoblasts (EVT) invade maternal uterine tissues and play a key role in placental development. EVT express HLA-C, a highly polymorphic antigen that can elicit allogeneic responses, and HLA-G, which is associated with ...
Henrieta Papuchova +8 more
semanticscholar +1 more source
Immunological Compatibility Status of Placenta-Derived Stem Cells is Mediated by Scaffold 3D Structure [PDF]
, 2018 Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have ...
Azizian, Sara +8 more
core +2 more sources
Frontiers in Immunology, 2021 Human leukocyte antigen G (HLA-G) is known as a novel immune checkpoint molecule in cancer; thus, HLA-G and its receptors might be targets for immune checkpoint blockade in cancer immunotherapy.
Hui-Hui Xu +6 more
doaj +1 more source
HLA-G Neo-Expression on Tumors
Frontiers in Immunology, 2020 HLA-G is known to modulate the immune system activity in tissues where physiological immune-tolerance is necessary (i.e., maternal-fetal interface, thymus, and cornea).
M. Loustau +5 more
semanticscholar +1 more source